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4.:1,2,4 Hish-d!!.ily lipoDror€itr {fl DL) rn.t Low-d.nrity<br />
liroproleir (LDL)<br />
An.lysis ol vdiae of plsmo HDL choler.rot @nqlrerion hs ben 8iv€n nr<br />
'fable 17 while oaltris of vaire ot pldm LDL chotsr€Dt l.vet nav. b..n sho*n in<br />
Tablc 39.1h.lrcltn nt (T, N.FeEmA sd ZnSOa did wh€n fd ro nr for 8 weti<br />
harc d.cFen HDL bd incr6.d LDL Oabt.s t8 dd 40) lisnitio.dy. HoBevd,<br />
chonSine ov* rl'e 3ource oauioc Ns ZnO hs decresed th€ t{DL signincdntly but did<br />
rot atl4t the LDL concenlBrion iD rhe ptosM otnd€ ral3. C[.n8. orer of iDn sur<br />
!s d.nq&l ion wnh ZnSOr h6 r€ilh* signifiMlly cltu8.d the LDL sd llDL<br />
co.c.nrrarion. Th€ elemcnral iDn widr z'to (Ir) did rdt.rr.r rh. IiDL G *ell B LDL<br />
plam<strong>ac</strong>once ratiotr of n.le Eis. Wheo ircn md zinc civ6 s a sinsle eue to the El5<br />
did nor sierificdrly cl@Be dE HDL sd LDL @ndtdrion cxept T. for LDL<br />
cholBt rol i! 0E p@nt sMr.<br />
.<br />
Donhm rt at (2@l) ried phm&ological doPs ofzihc od indided lnlt zino<br />
supnrddr h.d no ei<strong>ac</strong>r on lipopbr.in melabolisd a3 wll .s on ol<br />
'nlrkcrs<br />
hoh@sr6is. Poot .nd Ju6v.ld {t98) us€d iron ro alt r lDL-chol6lobl dd HD!.<br />
chol. .rcl .nd conolud.d rhol inq.6ing dieby non did not .fl.ot HDl.chol6l@l bd<br />
did incr4. LDL {hol€$.iol, In |h. praorl studr, ircn oloe 4 el.fttrt l ion or<br />
NaF.EDTA dld not alt€r th. LDL-clol.rlerol hokve, zirc 6 zino oxidc in Oe diet<br />
hav. irtsled LDl"cholcat.rol sisnificstly. The dehqd non s Ell s znso. in<br />
rh. di.r indicar.d a sisnificurly hign llDL- cholqt€ol onenuation without ch$8inr<br />
LoL{hol6t ol. On tn. odGr nbd, cl.mcnt'l iM wilh ziE oiid. f.iLd !o ptrd@ ey<br />
.lt mrion in lh. dsm dqdati@ oIHDl{hol.d.ol ud IDL{hol6l@1. Binkotki<br />
., dr edx) r*td rhc hrno$.lis th.t io. $pplcm.nl d@t nol inc6e $c<br />
rusc.plibihy of LDL lo underso otidaliv. modification in wond wilh bw non llllur'<br />
El H.ndy ./ ,1 (2001) lxplained lhe caultl E$rding dc.[ecl of zinc on<br />
hmdolosioll DlEntNds, Tnqy @podcd $dr Zn lev.l (38 ng/kg di.t, @ntrcl) !trd two<br />
low ld.ls lhal cr6dt. Zn d.ficicncics (19 ng/kg di€l lD ofcodrol ed 3.8 ng/r8 diel,<br />
Ulo of conlrol) in 8rcwins mole ui femal. Bl! rd l0 *ets dq*.d hish ddrny<br />
hpuprorein (llDL) i'1a Jo*.d
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