Duke University 2008-2009 - Office of the Registrar - Duke University

specialized compartments for protein segregation, process information, move and differentiate
will be addressed. Minicourse, 1st half-semester. Instructor: Schachat. 2 units.
243. Respiratory Proteins and the Environment. Structure, function and evolution of
copper and iron based respiratory proteins in response to environmental oxygen levels and
physiological needs. Lectures and readings on the balance between pathways for metabolic
oxygen utilization and alternative disease-causing pathways involving oxidative and
nitrosative reactions. Interactive molecular graphics and student presentations supplement
text and lectures. Covers molecular adaptations, circulation, allostery, reaction kinetics and
thermodynamics, reactive oxygen and nitrogen species, gene expression, blood pathogens,
malaria, sickle cell anemia. (Given at Beaufort) Instructor: C. Bonaventura. 3 units. C-L:
Environment 243, Marine Sciences
258. Structural Biochemistry I. 2 units. C-L: see Biochemistry 258; also C-L: Cell and
Molecular Biology 258, University Program in Genetics 258, Immunology 258, Structural
Biology and Biophysics 258, Computational Biology and Bioinformatics 258
259. Structural Biochemistry II. 2 units. C-L: see Biochemistry 259; also C-L:
Immunology 259, Computational Biology and Bioinformatics 259, Structural Biology and
Biophysics 259, University Program in Genetics 259
268. Biochemical Genetics II: From RNA to Protein. 2 units. C-L: see Biochemistry 268;
also C-L: Immunology 268, University Program in Genetics 268
280. Student Seminar. Preparation and presentation of seminars to students and faculty on
topics of broad interest to cell biology and physiology. Required of Department of Cell
Biology students. Instructor: Staff. 1 unit.
282. Mechanisms of Development/Developmental Genetics. Half-semester minicourse
targeted to first-year graduate students in the Biological Sciences. Taught sequentially in the
Fall semester with Biology 283. Introduces basic concepts of cell specification, morphogenesis,
induction, and other mechanisms that enable cells, tissues and organs to assemble the
animal. Emphasis is on model organisms, mainly Drosophila, C. elegans, mouse, and
zebrafish, where genomics, mutations, gene modifiers, epistasis analyses, gene knockouts,
and transgenesis, plus many other genetic approaches have yielded important insights into
the differentiation of cells and the development of complex organisms. Cross-listed with
Biology 282. Instructors: Fehon, Kirby, Klingensmith, McClay, and Wharton. 2 units. C-L:
Biology 282
283. Developmental Genetics. Half-semester mini-course targeted to first year graduate
students in the Biological Sciences. Taught sequentially in the Fall semester with Biology
282. Focuses on genetic approaches to solve mechanistic problems of development.
Emphasis is on model organisms, mainly Drosophilia, C. elegans, mouse and zebrafish,
where genomics, mutations, gene modifiers, epistasis analysis, gene knockouts, and
transgenesis, plus many other genetic approaches have yielded important insights into the
differentiation of cell and the development of complex organisms. Cross-listed with Biology
283. Instructors: Fehon, Kirby, Klingensmith, McClay and Wharton. 2 units. C-L: Biology
283
296. Developmental Biology Colloquium. Instructor: Staff. 3 units.
301. Human Structure & Function. Core course of preclinical curriculum presents
scientific principles underlying structure and function of the normal human body. Focuses
on gross anatomy, microscopic anatomy, and physiology of nine organ systems providing
the foundation for the practice of medicine. Registration of non-Pathologist's Assistant
students requires permission of Course Director. Instructor: Jakoi and Staff. 12 units.
312. Research. Specific areas of investigation include: membrane structure; extracellular
matrix; cell adhesion; cell motility; cytoskeletal elements; chromosome structure and
movement; genetics and molecular biology of contractile proteins; muscle ultrastructure;
gamete biology; molecular and structural biology of photoreceptors; hormone receptors; cell
growth; developmental biology; membrane transport and electrophysiology; metabolism;
Courses of Instruction 95