Discussion <strong>the</strong> nature <strong>of</strong> <strong>FAT10</strong>’s target prote<strong>in</strong>s. In addition, post-mortem bra<strong>in</strong>s <strong>of</strong> pa- tients with Hunt<strong>in</strong>gton’s or Alzheimer’s disease are be<strong>in</strong>g <strong>in</strong>vestigated for signs <strong>of</strong> <strong>FAT10</strong> enrichment <strong>and</strong> <strong>FAT10</strong> gene-targeted mice will be utilized to exam<strong>in</strong>e <strong>the</strong> requirement for <strong>FAT10</strong> <strong>in</strong> a drug-<strong>in</strong>duced model <strong>of</strong> Mallory-Denk body formation. Fur<strong>the</strong>rmore, cont<strong>in</strong>u<strong>in</strong>g studies <strong>in</strong>vestigat<strong>in</strong>g <strong>the</strong> role <strong>of</strong> <strong>FAT10</strong> <strong>in</strong> lymphocyte homeostasis as well as <strong>in</strong> <strong>the</strong> response to a number <strong>of</strong> additional <strong>in</strong>tracellular pathogens are also be<strong>in</strong>g conducted. 125
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Summary nicht von der katalytischen
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Introduction example contained in t
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Introduction dependent apoptosis in
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Introduction Interestingly, a recen
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The Autophagy-Lysosome System Intro
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Introduction The transport of misfo
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Chapter 1 The UBA domains of NUB1L
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Introduction Chapter 1 Ubiquitin, a
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Chapter 1 no correlation between th
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Chapter 1 covered proteins were sep
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Chapter 1 Figure 8: Accelerated deg
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Chapter 1 Treatment with IFN-γ and
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Chapter 1 ing SUMO-1-GFP or the C-t
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Chapter 1 domains of NUB1L is requi
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Chapter 2 Degradation of FAT10 by t
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Chapter 2 evaluation of the NUB1L b
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Chapter 2 teins which contain intri
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Chapter 2 Combined with our studies
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- Page 133 and 134: References J. A. Johnston, M. E. Il
- Page 135 and 136: References F. Lévy, N. Johnsson, T
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- Page 141 and 142: References S. Vijay-Kumar, C. E. Bu
- Page 143 and 144: Abbreviations aa amino acid AAA ATP
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