Role of the ubiquitin-like modifier FAT10 in protein degradation and ...

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References D. Zhang, S. Raasi, and D. Fushman. Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains. J Mol Biol, 377(1):162–180, Mar 2008a. D. W. Zhang, K. T. Jeang, and C. G. Lee. p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers. Oncogene, 27:27, 2006a. M. Zhang, C. M. Pickart, and P. Coffino. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J, 22(7):1488–1496, Apr 2003a. X. Zhang, Z. Yuan, Y. Zhang, S. Yong, A. Salas-Burgos, J. Koomen, N. Olashaw, J. T. Parsons, X.-J. Yang, S. R. Dent, T.-P. Yao, W. S. Lane, and E. Seto. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell, 27(2):197–213, Jul 2007. Y. Zhang, N. Li, C. Caron, G. Matthias, D. Hess, S. Khochbin, and P. Matthias. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. Embo J., 22(5):1168–79., 2003b. Y. Zhang, B. Gilquin, S. Khochbin, and P. Matthias. Two catalytic domains are required for protein deacetylation. J Biol Chem., 281(5):2401–4. Epub 2005 Nov 6., 2006b. Y. Zhang, S. Kwon, T. Yamaguchi, F. Cubizolles, S. Rousseaux, M. Kneissel, C. Cao, N. Li, H.- L. Cheng, K. Chua, D. Lombard, A. Mizeracki, G. Matthias, F. W. Alt, S. Khochbin, and P. Matthias. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol, 28(5):1688–1701, Mar 2008b. S. Zhong, S. Müller, S. Ronchetti, P. S. Freemont, A. Dejean, and P. P. Pandolfi. Role of SUMO-1modified PML in nuclear body formation. Blood, 95(9):2748–2752, May 2000. 141
Abbreviations aa amino acid AAA ATPase associated with various cellular activities Ab antibody ACAD activated cell-autonomous death AICD activation-induced cell death AIPL1 aryl hydrocarbon receptor-interacting protein-like 1 APC anaphase promoting complex ATG autophagy related ATP adenosine-5’-triphosphate AZ antizyme BAG Bcl-2-associated athanogene BMDCs bone marrow-derived dendritic cells BrdU bromodeoxyuridine BUZ binder of ubiquitin zinc-finger C-terminal carboxy-terminal CAT catalytic (domain) cDNA complementary DNA CHIP carboxyl-terminus of HSC70 interacting protein cpm counts per minute DALIS dendritic cell aggresome-like induced structures DC dendritic cell DHFR dihydrofolate reductase DLB dementia with Lewy bodies DNA deoxyribonucleic acid DUB de-ubiquitinating enzyme E6-AP E6-associated protein ER endoplasmatic reticulum ERAD endoplasmatic reticulum-associated degradation FAT10 HLA-F locus associated transcript GAPDH glyceraldehyde 3-phosphate dehydrogenase GFP green fluorescent protein GSH glutathione GST glutathione-S-transferase HA hemagglutinin HDAC histone deacetylase HECT homologous to E6-AP carboxyl-terminus HIV human immunodeficiency virus HSC heat-shock cognate HSF1 heat-shock factor 1 HSP heat-shock protein 142
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Role of the ubiquitin-like modifier
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Acknowledgements . . . . . . . . .
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Summary / Zusammenfassung English F
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Summary In conclusion, these result
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Summary nicht von der katalytischen
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The Ubiquitin-Proteasome-System The
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Introduction Figure 1: The 26S prot
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Introduction are the major source o
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Introduction majority of ubiquitin-
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Introduction example contained in t
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Introduction two modifiers apart fr
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Introduction Figure 4: Comparison o
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Introduction dependent apoptosis in
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Introduction Interestingly, a recen
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The Autophagy-Lysosome System Intro
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Introduction Figure 5: Molecular ma
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Introduction The transport of misfo
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Introduction where the proteasome i
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Chapter 1 The UBA domains of NUB1L
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Introduction Chapter 1 Ubiquitin, a
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Chapter 1 no correlation between th
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Chapter 1 covered proteins were sep
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Chapter 1 Figure 8: Accelerated deg
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Chapter 1 Treatment with IFN-γ and
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Chapter 1 ing SUMO-1-GFP or the C-t
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Chapter 1 Figure 12: Accelerated de
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Chapter 1 Figure 13: Co-immunopreci
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Chapter 1 domains of NUB1L is requi
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Chapter 1 Rad23 (Verma et al., 2004
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Chapter 1 FAT10-GFP expressing vect
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Chapter 2 Degradation of FAT10 by t
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Introduction Chapter 2 The proteaso
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Chapter 2 From our previous data it
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Chapter 2 Figure 14: Purified compo
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Chapter 2 evaluation of the NUB1L b
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Chapter 2 teins which contain intri
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Chapter 2 Combined with our studies
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Chapter 2 Recombinant expression of
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Chapter 2 et al., 2003), both at a
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Abstract Chapter 3 During misfolded
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Chapter 3 tion between the UPS and
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Chapter 3 Figure 18: HDAC6 interact
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Chapter 3 Figure 19: Both the BUZ d
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Chapter 3 of HDAC6 was required for
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Chapter 3 precipitates with HDAC6 (
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Page 105 and 106: Chapter 4 FAT10-deficient mice disp
Page 107 and 108: Chapter 4 Once the infection is cle
Page 109 and 110: Chapter 4 As both wild-type as well
Page 111 and 112: Chapter 4 Peptides. The synthetic p
Page 113 and 114: Introduction Chapter 5 Antibodies a
Page 115 and 116: Chapter 5 binant human and mouse GS
Page 117 and 118: Chapter 5 Figure 34: The antibodies
Page 119 and 120: Chapter 5 Figure 36: The antibody s
Page 121 and 122: Discussion 30 years ago, ubiquitin
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Page 125 and 126: Discussion Alternatively, FAT10 cou
Page 127 and 128: References D. T. Akey, X. Zhu, M. D
Page 129 and 130: References Y.-H. Chiu, Q. Sun, and
Page 131 and 132: References S. Gunawardena, L.-S. He
Page 133 and 134: References J. A. Johnston, M. E. Il
Page 135 and 136: References F. Lévy, N. Johnsson, T
Page 137 and 138: References J.-H. Park, H.-S. Jong,
Page 139 and 140: References P. Schreiner, X. Chen, K
Page 141: References S. Vijay-Kumar, C. E. Bu
Page 145 and 146: Amino Acids Alanine Ala A Arginine
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