Role of the ubiquitin-like modifier FAT10 in protein degradation and ...

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Abbreviations IAP inhibitor of apoptosis IF immunofluorescence IFN interferon IκBα NF-κB inhibitory protein α IL interleukin IP immunoprecipitation IPTG isopropylβ-D-1-thiogalactopyranoside ISG15 interferon-stimulated gene 15 LB Lewy body LCA Leber congenital amaurosis LCMV lymphocytic choriomeningitis virus LMP low molecular-weight protein LPS lipopolysaccharide MCMV mouse cytomegalovirus MHC major histocompatibility locus mRNA messenger ribonucleic acid MTOC microtubule organizing center N-terminal amino-terminal NEDD8 neuronal precursor cell-expressed developmentally down-regulated 8 NF-κB nuclear factor-κB NLS nuclear localization signal NUB1 NEDD8 ultimate buster 1 NUB1L NEDD8 ultimate buster 1-Long ODC ornithine decarboxylase PCR polymerase chain reaction PD Parkinson's disease Pi orthophosphate ion PML promyelotic leukemia qRT quantitative real-time RING really interesting new gene RT room temperature SCF Skp1-Cullin-F-box protein shRNA short hairpin RNA siRNA small interfering RNA SUMO small ubiquitin-like modifier TLR Toll-like receptor TNF tumor necrosis factor TNFR tumor necrosis factor receptor TSA trichostatin A Ub ubiquitin UBA ubiquitin associated UBD ubiquitin domain protein UbL ubiquitin-like modifier UBL ubiquitin-like ULP UbL-specific protease UPS ubiquitin proteasome system VCP valoisin containing protein WB Western blot wt wild-type 143
Amino Acids Alanine Ala A Arginine Arg R Asparagine Asn N Aspartic acid Asp D Cysteine Cys C Glutamine Gln Q Glutamic acid Glu E Glycine Gly G Histidine His H Isoleucine Ile I Leucine Leu L Lysine Lys K Methionine Met K Phenylalanine Phe F Proline Pro P Serine Ser S Threonine Thr T Tryptophane Trp W Tyrosine Tyr Y Valine Val V 144 Abbreviations
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Role of the ubiquitin-like modifier
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Acknowledgements . . . . . . . . .
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Summary / Zusammenfassung English F
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Summary In conclusion, these result
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Summary nicht von der katalytischen
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The Ubiquitin-Proteasome-System The
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Introduction Figure 1: The 26S prot
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Introduction are the major source o
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Introduction majority of ubiquitin-
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Introduction example contained in t
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Introduction two modifiers apart fr
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Introduction Figure 4: Comparison o
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Introduction dependent apoptosis in
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Introduction Interestingly, a recen
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The Autophagy-Lysosome System Intro
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Introduction Figure 5: Molecular ma
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Introduction The transport of misfo
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Introduction where the proteasome i
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Chapter 1 The UBA domains of NUB1L
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Introduction Chapter 1 Ubiquitin, a
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Chapter 1 no correlation between th
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Chapter 1 covered proteins were sep
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Chapter 1 Figure 8: Accelerated deg
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Chapter 1 Treatment with IFN-γ and
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Chapter 1 ing SUMO-1-GFP or the C-t
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Chapter 1 Figure 12: Accelerated de
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Chapter 1 Figure 13: Co-immunopreci
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Chapter 1 domains of NUB1L is requi
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Chapter 1 Rad23 (Verma et al., 2004
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Chapter 1 FAT10-GFP expressing vect
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Chapter 2 Degradation of FAT10 by t
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Introduction Chapter 2 The proteaso
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Chapter 2 From our previous data it
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Chapter 2 Figure 14: Purified compo
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Chapter 2 evaluation of the NUB1L b
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Chapter 2 teins which contain intri
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Chapter 2 Combined with our studies
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Chapter 2 Recombinant expression of
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Chapter 2 et al., 2003), both at a
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Abstract Chapter 3 During misfolded
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Chapter 3 tion between the UPS and
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Chapter 3 Figure 18: HDAC6 interact
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Chapter 3 Figure 19: Both the BUZ d
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Chapter 3 of HDAC6 was required for
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Chapter 3 precipitates with HDAC6 (
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90 Chapter 3
Page 93 and 94: Chapter 3 Figure 23: The model conj
Page 95 and 96: Chapter 3 HDAC6 is required for the
Page 97 and 98: Chapter 3 Figure 26: Both ubiquitin
Page 99 and 100: Chapter 3 also revealed endogenous,
Page 101 and 102: Chapter 3 and/or its conjugates is
Page 103 and 104: Chapter 3 (Hipp et al., 2005), pEGF
Page 105 and 106: Chapter 4 FAT10-deficient mice disp
Page 107 and 108: Chapter 4 Once the infection is cle
Page 109 and 110: Chapter 4 As both wild-type as well
Page 111 and 112: Chapter 4 Peptides. The synthetic p
Page 113 and 114: Introduction Chapter 5 Antibodies a
Page 115 and 116: Chapter 5 binant human and mouse GS
Page 117 and 118: Chapter 5 Figure 34: The antibodies
Page 119 and 120: Chapter 5 Figure 36: The antibody s
Page 121 and 122: Discussion 30 years ago, ubiquitin
Page 123 and 124: Discussion monomeric ubiquitin as w
Page 125 and 126: Discussion Alternatively, FAT10 cou
Page 127 and 128: References D. T. Akey, X. Zhu, M. D
Page 129 and 130: References Y.-H. Chiu, Q. Sun, and
Page 131 and 132: References S. Gunawardena, L.-S. He
Page 133 and 134: References J. A. Johnston, M. E. Il
Page 135 and 136: References F. Lévy, N. Johnsson, T
Page 137 and 138: References J.-H. Park, H.-S. Jong,
Page 139 and 140: References P. Schreiner, X. Chen, K
Page 141 and 142: References S. Vijay-Kumar, C. E. Bu
Page 143: Abbreviations aa amino acid AAA ATP
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