Brain Development: Normal Processes and the Effects of Alcohol ...

*Zhang and Lidow (2002); Popolo et al. (2004).
f Popolo et al. (2004).
'Ohtanietal. (2003).
**Haydar et al. (2000); Owens and Kriegstei n (2002).
M LoTurcoetal. (1995).
-Sadikot et al. (1998); Luk et al. (2003); Luk and Sadiko t (2004).
Abbreviations
AMPA a-amino-34iydroxy-5-methyl-4-isoxazol e
propionate
BrdU Bromodeoxyuridin e
e AMP cycli c adenylate monophosphat e
Cdk cyclin-dependen t kinas e
CNS centra i nervou s syste m
CP cortica l plat e
G gestationa l day
GABA y-aminobutyri c acid
GÈ ganglioni c eminenc e
[ 3 H]thymidine [
3 H]dT
IHZ intrahila r zone
IZ intermediat e zon e
LCN loca l circuit neuro n
MZ margina l zone
NMDA N-methyl-D-aspartat e
PFC prefronta l cortex
PN projectio n neuro n
PVE pseudostratifie d ventricular epitheliu m
Q probabilit y of cell cycle exit
Rb retinoblastom a protei n
SPP secondar y proliferative population
SZ subventricula r zone
VZ ventricula r zone
References
CELL PROLIFERATION 2 1
TABLE 2- 1 Summar y of effects o f dopamine, GABA, and glutamat e receptor activation on S-phas e labeling
indices in neocortical and neostriatal precursor populations of the fetal brain
Neocortex
Neostriatum
Precursor
Population
VZ
sz
VZ
sz
Dl
Decrease*
Decrease 1
f f
Decrease
Decrease n
Dopamine
D2
No effect 1
Increase *
Increase fî
Increase u
GABA
Receptor Subtype
GABAA
Increase**
Decrease ft
Decrease**
Not known
Not known
NMDA
No effect -
No effect * *
1 f
Increase
No effec t
Glutamate
AMPA/Kainate
Increase**
Decrease**-"'**
Decrease**
No effect * *
Noeffect u
No effect 1 '
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