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167 Geba GP, Weaver AL, Polis AB, Dixon ME, Schnitzer TJ. Efficacy of Rofecoxib, Celecoxib, andAcetaminophen in Osteoarthritis of the Knee. JAMA. 2002;287:64-71.168 Rampal P, Moore N, VanGanse E, La Parc JM, Wall R, Schneid H et al. Gastrointestinal tolerability ofibuprofen compared with paracetamol and aspirin at over-the-counter doses. J Int Med Res. 2002; 30:301-8.169 Silverfield JC, Kamin M, Wu SC, Rosenthal N; CAPSS-105 Study Group. Tramadol/acetaminophencombination tablets for the treatment of osteoarthritis f<strong>la</strong>re pain: a multicenter, outpatient, randomized,double-blind, p<strong>la</strong>cebo-controlled, parallel-group, add-on study. Clin Ther. 2002;24:282-97.170 Graham DY, Smith JL. Effects of aspirin and an aspirin-acetaminophen combination on the gastricmucosa in normal subjects. A double-blind endoscopic study. Gastroenterology. 1985;88:1922-5. 65171 Stern AI, Hogan DL, Kahn LH, Isenberg JI. Protective effect of acetaminophen against Aspirin- andEthanol-Induced damage to the human gastric mucosa. Gastroenterology. 1984;86:728-33.172 Lanas A, Martin-Mo<strong>la</strong> E, Ponce J, Navarro F, Pique JM, B<strong>la</strong>nco FJ. Recomendaciones <strong>de</strong> <strong>la</strong>Asociación Españo<strong>la</strong> <strong>de</strong> Gastroenterología y <strong>de</strong> <strong>la</strong> Sociedad Españo<strong>la</strong> <strong>de</strong> Reumatología. Disponible en:http://www.ser.es/ArchivosDESCARGABLES/consensos/ConsensoAEG-SER-Final090603.pdf.(consultado 5-3-2011).173Rahme E, Pettitt D, LeLorier J. Determinants and seque<strong>la</strong>e associated with utilization ofacetaminophen versus traditional nonsteroidal antiinf<strong>la</strong>mmatory drugs in an el<strong>de</strong>rly popu<strong>la</strong>tion. Arthritis& Rheum. 2002;46:3046-54.174 Garcia Rodriguez LA, Hernan<strong>de</strong>z-Diaz S. Re<strong>la</strong>tive risk of upper gastrointestinal complications amongusers of acetaminophen and nonsteroidal anti-inf<strong>la</strong>mmatory drugs. Epi<strong>de</strong>miology. 2001;12: 570-6.175 Bianchi Porro G, Ardizzone S, Petrillo M, Car<strong>uso</strong> I, Montrone F. Endoscopic assessment of the effectsof dipyrone (metamizol) in comparison to paracetamol and p<strong>la</strong>cebo on the gastric and duo<strong>de</strong>nal mucosaof healthy adult volunteers. Digestion. 1996;57:186-90.176 Laporte JR, Carné X, Vidal X, Moreno V, Juan J. Upper gastrointestinal bleeding in re<strong>la</strong>tion toprevious use of analgesic and non-steroidal anti-inf<strong>la</strong>mmatory drugs. Lancet. 1991; 1:85-9.177 Lanas A, Serrano P, Bajador E, Fuentes J, Sáinz R. Risk of upper gastrointestinal bleeding associatedwith non-aspirin cardiovascu<strong>la</strong>r drugs, analgesics and nonsteroidal anti-inf<strong>la</strong>mmatory drugs. Eur JGastroenterol Hepatol. 2003;15:1-6.178 Edwards JE, Meseguer F, Faura CC, Moore RA, McQuay HJ. Single-dose dipyrone for acutepostoperative pain. Cochrane Database Syst Rev. 2001; (3):CD003227.179 Ro<strong>de</strong>rick PJ, Wickes HC, Mea<strong>de</strong> TW. The gastrointestinal toxicity of aspirin: an overview ofrandomised controlled trials. Br J Clin Pharmacol. 1993; 35: 219-26.180 Algra A, Greving JP. Aspirin in primary prevention: sex and baseline risk matter. Lancet. 2009; 373(30): 1821-22.181 Antip<strong>la</strong>telet Trialists' Col<strong>la</strong>boration. Col<strong>la</strong>borative overview of randomised trials of antip<strong>la</strong>telettherapy: II. Maintenance of vascu<strong>la</strong>r graft or arterial patency by antip<strong>la</strong>telet therapy. BMJ. 1994; 308:159-68.182 SIGN. Scottish Intercollegiate Gui<strong>de</strong>lines Network. [Internet] Escocia. Antithrombotic TherapySection 11: Antip<strong>la</strong>telet agents. Disponible en:http://www.sign.ac.uk/gui<strong>de</strong>lines/fulltext/36/section11.html (consultada 7-3-2011).105
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GUÍA DE PRÁCTICA CLÍNICAEMPLEO D
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FECHA (mm/aaaa)ELABORADO POR Grupo
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Carlos López FélezMédico de Fami
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ABREVIATURAS Y SIGLASAAS: Acido Ace
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CAPITULO 12. EN UN PACIENTE POLIMED
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PACIENTES EN TRATAMIENTO CRÓNICO C
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Recomendaciones: A,B,C; √ recomen
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Este consumo es muy superior al del
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Estos hechos apoyan la necesidad de
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Los límites utilizados en la búsq
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Tabla 2. Criterios GRADE para valor
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Capitulo 2CONSIDERACIONES GENERALES
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tenían un RR de HDA de 1,94 (1,61-
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Tabla 6.Riesgo de hemorragia digest
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evidencia III). Según revisiones p
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Tabla 8. Riesgo de hemorragia diges
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(deficiencias de comunicación entr
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Siguiendo las directrices del Coleg
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que toman AINE o inhibidores COX-2,
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evisión Cochrane 71 , en pacientes
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inhibidores de la bomba de protones
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aproximadamente una cuarta parte de
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días, en comparación con los que
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adultos jóvenes (sólo en seis est
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- Page 56 and 57: (nivel de evidencia Ia). Los autore
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- Page 66 and 67: que metamizol y propifenazona no in
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- Page 90: Anexo 1DECLARACIÓN DE INTERÉS90
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- Page 103: people with osteoarthritis. BMJ. 20
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