Gerçek Yaşamda Karaciğer ve İnflamatuar Barsak Hastalıkları Sempozyumu
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SS11<br />
The role of Tacstd-2 le<strong>ve</strong>l in hepatitis C patients (controlledclinicalresearch)<br />
Memduh Şahin<br />
Şişli Hamidiye Etfal Eğitim <strong>ve</strong> Araştırma Hastanesi Gastroenteroloji<br />
Objecti<strong>ve</strong>s: Hepatitis C virus is one of theleadingcauses of li<strong>ve</strong>rcirrhosisandhepatocellularcarcinoma. Thetumor-associatedca<br />
lciumsignaltransducer 2 (Tacstd-2) molecule is thoughtto be invol<strong>ve</strong>d in theexpression of a number of moleculesthatfacilitate<br />
transport of hepatitis C intothecell. Theaim of thisstudywastoin<strong>ve</strong>stigate Tacstd-2 concentrations in hepatitis C patients,<br />
withandwithoutcirrhosis, andcomparewithuninfectedcontrols.<br />
Methods: Sixty-onehepatitis C patientsandtwenty-nine control (hepatitis C antibodynegati<strong>ve</strong>patientswithdyspepticcomplaints)<br />
caseswererecruitedbetween 2014 and 2016. Tacstd-2 concentrationsinallhepatitis C<br />
andcontrolpatientsweremeasuredandcompared. Inadditioncirrhoticandnon-cirrhotichepatitis C patientswerecompared in terms<br />
of Tacstd-2 concentrationandcomparisonwasmadebetweenpatientswithhighandlowconcentrations of Tacstd-2.<br />
Results: Subjectsconsisted of sixty-one (67.8%) Hep C positi<strong>ve</strong>patientsandcontrols (Hepatitis C<br />
antibodynegati<strong>ve</strong>patientswithdyspepticcomplaints) weretwenty-nine (32.2%) healthypatients. Forty one (67.2%) of sixty<br />
one Hep C patients were male and twenty patients (32.8%) were female. Forty-one (67.2%) of the Hep C patients were noncirrhotic<br />
and 20 subjects (32.8%) were from the cirrhotic group.In the Hep C group, 44 patients (72.1%) patients had the Hep<br />
C 1b genotype 1b. Genotype and mean HCV RNA le<strong>ve</strong>ls of Hep C patients in the study are shown in Table 1. Three of the<br />
cirrhotic patients had hepatocellular carcinoma. The mean Tacstd-2 concentration of patients with Hep C was significantly<br />
higher (p=0.043) at 691.2 ±473.3 ng/U than in the healthy control group (524±290.1 ng/U) (see Table 2). When the Hep C<br />
patient group was stratified by the presence of cirrhosis cirrhotic patients had a mean Tacstd-2 concentration of 715.5±333.9<br />
ng/U while non-cirrhotic patients had a mean concentration of 679.3±447.4 ng/U although this was not statistically significant<br />
(p=0.78) (Table 3).<br />
Patientswerestratifiedaccordingtolow (500 ng/U; Group B) Tacstd-2<br />
concentrations. Li<strong>ve</strong>rfunctiontestsshowedthataspartateaminotransferase (AST) andalanineaminotransferase<br />
(ALT) concentrationsweresignificantlyhigher in group A patientscomparedwithgroup B patients.<br />
Therewasnodifferencebetweenthegroups in terms of alkaline phosphatase (ALP), gamma-glutamyltranspeptidase (GGT)<br />
orbilirubinconcentrations. Con<strong>ve</strong>rselythe hemoglobin valuewasfoundto be statisticallylower in group B than in group A (Table<br />
4).<br />
Inourstudy, a correlationbetween Tacstd-2 and AST (r: -0.31, p: 0.02) and ALT (r: -0.29, p: 0.03)<br />
concentrationswasfound in Hep C patients. Therewasnocorrelationbetween Tacstd-2 andhematologicalparametersor Hep<br />
C RNA concentration (Table 5). Inthelinearregression model, only hemoglobin concentrationwasfoundto be dependent on<br />
Tacstd-2 concentration in Hep C patients (p=0.007) as shown in Table 6.<br />
TABLES<br />
Table 1. Comparison of viral load and Tacstd-2 concentration in Hepatitis C positi<strong>ve</strong> patients by viral<br />
genotype.<br />
Genotype 1b<br />
Non –Genotype1b<br />
p<br />
(n=49)<br />
(1a,2,3,4) (n=12)<br />
HCV RNA 171x10 4 ±604x10 4 286x10 4 ±623 x10 4 0.60<br />
Tacstd-2 708±492 613±382 0.55<br />
21
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