Donepezil, rivastigmine, galantamine and memantine for ...

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The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer’s disease E Loveman, * C Green, J Kirby, A Takeda, J Picot, E Payne and A Clegg Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK * Corresponding author Declared competing interests of authors: none Other competing interests: the lead editor of this monograph was a member of the Trial Steering Committee for AD2000 Published January 2006 This report should be referenced as follows: Loveman E, Green C, Kirby J, Takeda A, Picot J, Payne E, et al. The clinical and costeffectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer’s disease. Health Technol Assess 2006;10(1). Health Technology Assessment is indexed and abstracted in Index Medicus/MEDLINE, Excerpta Medica/EMBASE and Science Citation Index Expanded (SciSearch ® ) and Current Contents ® /Clinical Medicine.
Page 1: Health Technology Assessment 2006;
Page 5 and 6: Objectives: To provide an update re
Page 7 and 8: List of abbreviations .............
Page 9 and 10: AChEI acetylcholinesterase inhibito
Page 11 and 12: Epidemiology and background Alzheim
Page 13: Galantamine Five published economic
Page 17 and 18: Description of underlying health pr
Page 19 and 20: TABLE 1 Estimated prevalence of AD
Page 21 and 22: as one component of their care. A n
Page 23 and 24: The a priori methods used for syste
Page 25: Data synthesis Data were synthesise
Page 28 and 29: 14 Clinical effectiveness TABLE 3 C
Page 30 and 31: 16 Clinical effectiveness TABLE 3 C
Page 32 and 33: 18 Clinical effectiveness particula
Page 34 and 35: 20 Clinical effectiveness Compariso
Page 36 and 37: 22 Clinical effectiveness TABLE 6 M
Page 38 and 39: 24 Clinical effectiveness donepezil
Page 46 and 47: 32 Clinical effectiveness DAD The D
Page 48 and 49: 34 Clinical effectiveness clinical
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38 Clinical effectiveness TABLE 10
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40 Clinical effectiveness statistic
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44 Clinical effectiveness Compariso
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46 Clinical effectiveness Summary:
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48 Clinical effectiveness differenc
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52 Clinical effectiveness This appe
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58 Clinical effectiveness Compariso
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62 Clinical effectiveness placebo [
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66 Clinical effectiveness (24 mg/da
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70 Clinical effectiveness ● One R
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72 Clinical effectiveness by the pa
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78 Clinical effectiveness donepezil
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80 Evidence from systematic reviews
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82 Economic analysis TABLE 48 Chara
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84 TABLE 49 Economic analysis Outli
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86 Economic analysis The UK study r
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88 Economic analysis The AD2000 stu
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90 Economic analysis term). Where w
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92 Economic analysis published econ
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94 Economic analysis Fenn and Gray
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96 Economic analysis one another. W
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98 Economic analysis outcomes: (1)
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100 Economic analysis respond to ga
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102 Economic analysis donepezil, ri
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104 Economic analysis of this study
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106 Economic analysis independent,
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108 Economic analysis classificatio
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110 Economic analysis survey studie
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112 Economic analysis vascular deme
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114 Economic analysis Livingston an
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116 Economic analysis sensitive to
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118 Economic analysis Neumann and c
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120 Economic analysis The model str
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122 Economic analysis CEA, given th
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124 Economic analysis TABLE 70 Key
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126 Economic analysis TABLE 73 Prof
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128 Economic analysis Probability o
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130 Economic analysis Results are s
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132 Economic analysis 4. The model
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134 Economic analysis perspective e
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136 Economic analysis indicating th
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Ongoing research, with relevance to
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The increasing numbers of the very
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146 Discussion and conclusions dose
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148 Discussion and conclusions effo
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150 Discussion and conclusions Stre
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1. Clegg A, Bryant J, Nicholson T,
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placebo-controlled study of donepez
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94. Brooks E, Deal L. The effect of
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of memantine in patients with moder
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This version of HTA monograph volum
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376 Health Technology Assessment Pr
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378 Health Technology Assessment Pr
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