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Donepezil, rivastigmine, galantamine and memantine for ...

Donepezil, rivastigmine, galantamine and memantine for ...

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TABLE 49 Outline detail on the modelling methods/structure used in the cost-effectiveness literature <strong>for</strong> donepezil (cont’d)<br />

Stewart et al., Jönsson et al., O’Brien et al., Neumann et al., Ikeda et al., Fagnani et al., Industry submission<br />

199882 199984a 199985 199986 200287 200389 Total annual costs<br />

(UK£) by severity<br />

group (excluding drug<br />

cost)<br />

Severe £25,488<br />

Moderate £17,950<br />

Mild £13,327<br />

Minimal £9,515<br />

Monthly costs (Euro)<br />

by MMSE score:<br />

Home care<br />

>20 192<br />

16–20 659<br />

11–15 1319<br />

≤ 10 4105<br />

Non-medical/medical<br />

institution<br />

>20 682/891<br />

16–20 923/1131<br />

11–15 1083/1292<br />

≤ 10 1340/1548<br />

Values <strong>for</strong> cost inputs<br />

are not given<br />

although the values<br />

from which cost<br />

inputs were<br />

calculated are<br />

provided<br />

Costs (US$) by stage<br />

<strong>and</strong> setting<br />

Mi/C 46,277<br />

Mi/N 46,776<br />

Mo/C 56,559<br />

Mo/N 57,170<br />

S/C 65,695<br />

S/N 66,404<br />

Expected costs<br />

(Can$) per 6-month<br />

cycle by MMSE score<br />

21–26 3,719<br />

15–20 6,754<br />

10–14 10,765<br />

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