Donepezil, rivastigmine, galantamine and memantine for ...

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Clinical effectiveness
TABLE 6 MMSE for donepezil
AD2000 2004 43 Change from baseline Numbers estimated from figure
Donepezil 5 mg/day or 10 mg/day
(n = 154)
Placebo (n = 160) p-Value versus placebo
–1.5 –1.75 Not reported a
Gauthier et al., 2002 41 Standardised MMSE least-squares mean change from baseline Numbers estimated from
figure
Donepezil 10 mg/day (n = 91) Placebo (n = 100) p-Value versus placebo
1.5 –0.56 0.0002
Holmes et al., 200449 Mean change from baseline ± SEM
Donepezil 10 mg/day (n = 41) Placebo (n = 55) p-Value versus placebo
–0.1 (0.6) –1.8 (0.5) p = 0.02
Mohs et al., 200146 Adjusted mean change from baseline Numbers estimated from figure
Donepezil 10 mg/day (n = 207) Placebo (n = 208) p-Value versus placebo
0.6 (n = 207) –0.6 (n = 208) p < 0.001
Nunez et al., 200348 Least-squares mean change from baseline Numbers estimated from figure
Donepezil 10 mg/day (n = 99) Placebo (n = 103) p-Value versus placebo
1.7 0.5 p < 0.05
Winblad et al., 200147 Wimo et al., 2003 56 Least-squares mean change from baseline ± SE Numbers estimated
from figure
Donepezil 10 mg/day (n = 142) Placebo (n = 144) p-Value versus placebo
–0.46 ± 0.34 (n = 135) –2.18 ± 0.29 (n = 137) p < 0.001
Rogers et al., 199851 Mean change from baseline ± SE
1. Donepezil 5 mg/day 2. Donepezil 10 mg/day 3. Placebo (n = 154) p-Value versus placebo
(n = 153) (n = 150)
0.24 ± 0.29 0.39 ± 0.29 –0.97 ± 0.28 1. p = 0.0007
2. p = 0.0002
Rogers et al., 199852 Least-squares mean change from baseline ± SEM
1. Donepezil 5 mg/day 2. Donepezil 10 mg/day 3. Placebo (n = 150) p-Value versus placebo
(n = 156 ) (n = 156)
1.0 ± 0.25 1.3 ± 0.24 0.04 ± 0.25 1. p < 0.004
2. p < 0.001
Rogers et al., 199653 Adjusted mean (min., max.) change from baseline
1. Donepezil 2. Donepezil 3. Donepezil 4. Placebo p-Value versus placebo
1 mg/day 3 mg/day 5 mg/day (n = 40)
(n = 42) (n = 40) (n = 39)
0.6 (–4.0, 7.0) 0.9 (–7.0, 5.0) 2.0 (–1.0, 7.0)
p < 0.05 relative to 1 mg
1.2 (–6.0, 8.0) Not reported
Rogers et al., 199653 Mean change from baseline Numbers estimated from figure
1. Donepezil 2. Donepezil 3. Donepezil 4. Placebo p-Value versus placebo
1 mg/day 3 mg/day 5 mg/day (n = 40)
(n = 42) (n = 40) (n = 39)
0.66 0.80 2.00 1.37 Not reported
a p-Values were reported for the overall treatment effect (p < 0.0001) rather than for the difference between groups at this
particular time point (60 weeks).