Report No xxxx - Instytut Fizyki JÄ drowej PAN

selected in GM in VHL and Ventral Horn Right (VHR), in WM in PFL and Posterior
Funiculus Right (PFR) for diffusion gradient along X, Y directions. The average values of
diffusion components in the Ventral Horn in GM are: D f =(1.11±0.17) 10 -3 mm 2 /s,
A f =0.54±0.07 and D s=(0.14±0.03) 10 -3 mm 2 /s, As=0.46±0.07. For WM in the Posterior
Funiculus the corresponding values are: D f =(1.35±0.55) 10 -3 mm 2 /s, A f =0.74±0.07 and
D s =(0.08±0.02) 10 -3 mm 2 /s, A s=0.26±0.07. Our results are within the limits of human brain
data [10] and full DTI data for the rat spinal cord at Th7 [11].
Conclusion:
We have demonstrated the existence of non-monoexponential diffusion in the human CSC
that can be approximated by fast and slow diffusion components.
1
b=450 s/mm 2
b=900 s/mm 2 b=5000 s/mm 2
Fig. 1. DW images from a slice through the center of
C5 for different b values. Note increasing contrast
between GM and WM at b=5000 s/mm 2 .
Fig. 2. Dependence of signal amplitude on diffusion
0 1000 2000 3000 4000 5000 6000 700
A
0,1
GM-VHR
WM-FCR
weighting along X direction in CSC at C5 level in
GM – VHR, in WM – FCR. Solid lines represent the
biexponential fit.
b [s/mm 2 ]
References:
1) Clark, et al., MRM 41:1269-1273 (1999); 2) Alsop, MRM 38:527-533 (1997); 3) Le
Roux et al., MAGMA 14:243-247 (2002); 4) Ries et al., MRM 44:884-892 (2000); 5)
Bammer et al., JMRI 15:364-373 (2002); 6) Shimony et al., Proc. 8 ISMRM 773 (2000);
7) Wheeler-Kingshott et al., NeuroImage 16:93-102 (2002), 8) Jasinski et al., Proc. 11
ISMRM 2462 (2003), 9) Clark, et al., MRM 44:852-859 (2000), 10) Inglis et al., MRM
45:580-587 (2001), 11) Elshafiey et al., MRI 20:243-247 (2002).
0 8000
106