Report No xxxx - Instytut Fizyki JÄ drowej PAN

NEW HEPATOTROPIC PREPARATIONS FOR MR IMAGING
OF LIVER AND BILE DUCTS DISEASES
Elżbieta Mikiciuk-Olasik*, Bolesław Karwowski*, Małgorzata Witczak*, Paweł Szymański*,
EmiliaWojewoda ** , Michał Studniarek #
* Zakład Chemii Farmaceutycznej i Analizy Leków Uniwersytet Medyczny, Łódź, Poland;
** Zakład Biofarmacji Katedra Biofarmacji Uniwersytet Medyczny, Łódź, Poland;
# Instytut Radiologii i Medycyny Nuklearnej Akademii Medycznej, Gdańsk, Poland
Problems in NMR diagnosis of liver and biliary ducts diseases can be divided into the
problems related to morphology as well as the problems related to function of these organs.
Morphological assay can be useful in identification and distinction of focal changes in
liver and in finding the reasons of cholestasia. Application of hepatotropic contrast agents in
both fields could have remarkable influence on the effectiveness of NMR diagnosis. In that
case the increase of relationship: the signal to the noise versus contrast agent to the noise can
be observed in pathological changes. Actually there is no possibility for non-invasive
estimation of the morphology and function of the biliary ducts.
There is no literature data for gadoline complexes that are subject of our study.
Preliminary investigation of that compounds showed up strong affinity to hepatocytes. After
injections of gadolinium complexes into the rats considerable increase of signal intensity was
observed in NMR tomography. The knowledge of difference between signal intensity before
and after application of the contrast agent gives the possibilities of quantitative analyses for
the degree of its accumulation in liver cell. In the consequence we can receive the valuable
diagnostic tool for investigation of pathological changes in the liver.
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