biologia - Studia

MODIFICATIONS OF BONE PARAMETERS IN OSTEOPOROSIS
normal values at the hip bone (9.72%). According to these values (Fig. 5) we noticed
that the axial skeleton is preponderantly affected. The fact that we included, in our
research, the secondary osteoporosis cases contributes to these results; the main part of
these causes (the excess of glucocorticoid hormones, the hyperthyroidism, the
malabsorption syndrome, the rheumatoid polyarthritis, certain medication) have as a
result the initial damage at the vertebral column (Moayyeri et al., 2005).
The existence of two different T-score categories for two anatomic regions
of the same patient has been described in the literature as discordance in diagnosis.
The discordance is minor if the diagnostic categories are adjacent (osteoporosis –
osteopenia, osteopenia – normal values). When the diagnostic categories are
osteoporosis – normal values, the discordance is major.
There are multiple causes for the discordance in diagnosis. They can be of
a physiological nature, connected to the natural adaptive reaction of the skeleton to
internal and external factors, of a physiopathological nature, as a consequence of an
anatomical affection and connected to the presence and composition of the
surrounding tissues, of technical nature, concerning the equipment used for
determination or the faulty determination. Moayyeri et al., (2005) have researched this
discordance in diagnosis in osteoporosis. Most of the patients included in their
research (58.3%) had the same T-score categories both at the vertebral column and at
the hip bone, a minor discordance in diagnosis was encountered in 38.9% of the
cases, while a major discordance was found in only 2.7% of the cases.
Fig. 5. Diagnostic categories at the vertebral column and at the hip. According to the T-
score determined for each patient both at the vertebral column and at the hip bone we
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