Siratro Extract BG - Cosmesi.it

NIKKO CHEMICALS CO., LTD.
1-4-8 NIHONBASHI-BAKUROCHO, CHUOKU, TOKYO, 103-0002, JAPAN Email: inter@nikkol.co.jp www.nikkol.co.jp
Collagen Quality Enhancer
New oil-soluble derivative of vitamin C boosts
HSP47 to improve quality and organization of collagen.
VCE
INCI Name: 3-O-Cetyl Ascorbic Acid.
NEW
VCE is an oil-soluble ether of vitamin C. It effectively promotes expression of Heat Shock Protein 47
(HSP47) resulting in improved quality and organization of collagen fibers. Better organization of
collagen provided by VCE increases skin firmness and elasticity.
VCE also effectively boosts synthesis of type I collagen.
Many anti-aging active ingredients focus on
increase of collagen amount in skin. However,
another extremely important aspect is quality of
collagen. it is essential to produce thick and firm
collagen fibers, strong enough to support epidermis
and prevent wrinkle formation.
HSP47 is the main factor of proper collagen synthesis
(molecular chaperone). HSP47 is the protein whose
function is to assist procollagen in achieving proper
folding. HSP47 facilitates productive folding of
procollagen with preventing its aggregation in the
ER (endoplasmic reticulum). Several reports were
made on importance of HSP47 in collagen formation
process.
As HSP47 synthesis decreases with age, VCE, as an
active molecule with ability to increase HSP47, is a
very important ingredient for modern anti-aging skin
care product.
Normal
Abnormal
(suppressed HSP47)
Electron microscopic images of
collagen fibers
HSP47 protein(Abs.405/protein)
12.0
10.0
8.0
6.0
4.0
2.0
0.0
* p