Siratro Extract BG - Cosmesi.it

NIKKO CHEMICALS CO., LTD.
1-4-8 NIHONBASHI-BAKUROCHO, CHUOKU, TOKYO, 103-0002, JAPAN Email: inter@nikkol.co.jp www.nikkol.co.jp
Anti-oxidation / Anti-stress
Zinc-Glycine
Complex
In the body, metallothionein, an antioxidant protein, acts as a natural sunscreen to reduce
adverse effects of UV irradiation. Metallothionein is very effectively induced by zinc, however, zinc
in ionized form has poor skin penetrating ability and cannot be uptaken into cells in sufficient
amounts. To solve this problem, we synthesized and examined various types of zinc complexes
containing different amino acids as ligands. As a result, we have developed Zinc-Glycine
Complex, a zinc complex with glycine, which showed superior induction of metallothionein in the
body and effectively reduced oxidative stress.
Zinc-Glycine Complex triggers expression of intracellular
metallothionein that inhibits tyrosinase activity.
It enhances cells’ tolerance to UV radiation and oxidative stress
and reduces UV-induced melanogenesis.
Effect on expression of intracellular metallothionein (MT)
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Zinc-Glycine Complex, at different concentrations, and
10 μmol/L zinc chloride, as a reference, were added to
different samples of human keratinocytes (HaCaT cells).
After a 24-hour incubation period, MT protein expression
was analyzed using ELISA method. Zinc-Glycine Complex
increases the amount of MT more efficiently compared to
zinc chloride.
MT protein expression analyzed using ELISA method
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