Siratro Extract BG - Cosmesi.it

NIKKO CHEMICALS CO., LTD.
1-4-8 NIHONBASHI-BAKUROCHO, CHUOKU, TOKYO, 103-0002, JAPAN Email: inter@nikkol.co.jp www.nikkol.co.jp
Epidermal-Dermal Junction
New approach to deep wrinkles and other signs of aging
NEW NEW
Siratro Extract BG
Extracted from one the fastest growing plants in the world, Siratro Extract BG
demonstrates a strong stimulation of the synthesis of laminin-5 and collagen type
IV, the main components of the epidermal-dermal junction (EDJ).
The complex linking the dermis with the epidermis plays a critical role in wrinkle
formation. Thus, the EDJ is designed to bind collagen fibers in the upper part of
dermis with the epidermal base membrane, allowing collagen to fulfill its main
function: to support the epidermis and maintain the skin’s elasticity.
If the EDJ is damaged, proper bonding of collagen with epidermis is impaired,
resulting in the formation of deep wrinkles and sagging.
In vitro: increase of laminin-5 production
Laminin-5
production (%)
300
250
200
150
100
50
0
cont.
**
Siratro Extract
BG (0.5%)
Ex vivo: increase of collagen type IV in 3D skin
model (after 14 days)
Control
Siratro Extract BG
Before
After 1 month
In vivo: improvement of deep wrinkles
(cream with 1% Siratro Extract BG)
Siratro
Extract BG
(1%)
Subjects: 10.
Application: Twice daily for 1 month
(eye area).
Evaluation : Replica method.
Placebo
Epidermis
Dermis
Stimulation of synthesis of epidermal-dermal junction
Stimulation of synthesis of epidermal-dermal junction
(EDJ) results in visual improvement of deep wrinkles
(EDJ) results in visual improvement of deep wrinkles
2010.03