Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

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For Garbhan, Nancy, Gail, Peter, Ebony, George, Jack, Max, Graham, Gillian, Fionna, Granua, Thomas, Victor, Iontac, Lolo, Nanna, Donaghue and all the others iii
Table of Contents Acknowledgements .....................................................................................................v 1 Abstract/Summary............................................................................................... 1 1.1 Literature Review (chapter 3) ....................................................................... 1 1.2 Lifespan, Causes of Death, Genetics (chapters 4 to 6)................................ 2 1.3 Discussion and Conclusions (chapter 7) ...................................................... 4 2 Introduction.......................................................................................................... 7 3 Literature Review ................................................................................................ 9 3.1 Lifespan in General ...................................................................................... 9 3.2 Intrahepatic Portosystemic Shunt (PSS) .................................................... 15 3.3 Dilatative Cardiomyopathy (DCM).............................................................. 18 3.4 Osteogenic Sarcoma (OS) ......................................................................... 24 3.5 Gastric Dilation and Volvulus (GDV) .......................................................... 28 3.6 Rhinitis/Bronchopneumonia Syndrome – PCD........................................... 31 3.7 Juvenile Fibrocartilaginous Embolism (FCE).............................................. 34 3.8 Epilepsy...................................................................................................... 37 3.9 Osteochondrosis (OC)................................................................................ 41 3.10 Von Willebrand’s Disease (vWD) ............................................................... 43 3.11 Progressive Retinal Atrophy (PRA) ............................................................ 45 3.12 Miscellaneous............................................................................................. 47 3.13 Clinical Reference Values .......................................................................... 50 4 Dogs, Materials and Methods............................................................................ 52 4.1 Dogs........................................................................................................... 52 4.2 Software ..................................................................................................... 52 4.3 Definition of Causes of Death..................................................................... 54 4.4 Definition of Right Censored Data.............................................................. 54 5 Results of Past Studies Revisited...................................................................... 55 5.1 Re-analysis of Bernardi (1986) and Prokopenko (1998) ............................ 55 5.2 Analysis of Murphy (1991).......................................................................... 59 6 Analysis of the Present Data ............................................................................. 64 6.1 Population Structure and Genetics............................................................. 64 6.2 Lifespan...................................................................................................... 68 6.3 Population Genetics of Dogs Born 1965 and After..................................... 76 6.4 Ancestor Analyses of Diseases Presumed Hereditary ............................... 81 7 Discussion ......................................................................................................... 91 7.1 Lifespan...................................................................................................... 91 7.2 Population Genetics ................................................................................... 96 7.3 Ethical Considerations...............................................................................105 7.4 Future Prospects in Breeding....................................................................110 7.5 Future Research Prospects.......................................................................113 8 References .......................................................................................................115 9 Appendix ..........................................................................................................124 iv
Page 1 and 2: Aus der Abteilung Tierhaltung und T
Page 3: Omnia mors poscit - lex est, non po
Page 7 and 8: 1 Abstract/Summary This study inves
Page 9 and 10: 1.2.3 Own Data A worldwide pedigree
Page 11 and 12: Due to the frequent bottlenecks dur
Page 13 and 14: 2 Introduction "It is impossible to
Page 15 and 16: 3 Literature Review Several disease
Page 17 and 18: previous results (Comfort 1960). No
Page 19 and 20: the average ages were significantly
Page 21 and 22: 3.2 Intrahepatic Portosystemic Shun
Page 23 and 24: Conservative therapy is also indica
Page 25 and 26: mitochondrial hyperplasia, disrupti
Page 27 and 28: there are marked individual differe
Page 29 and 30: 3.3.2 Epizootology Numbers publishe
Page 31 and 32: 2002). On the molecular level, the
Page 33 and 34: 3.4.2 Epizootology In past studies
Page 35 and 36: 3.5.1.3 Diagnosis The history and c
Page 37 and 38: 3.5.2 Epizootology A prospective st
Page 39 and 40: Differential diagnoses include recu
Page 41 and 42: 3.7.1.3 Diagnosis The definite diag
Page 43 and 44: Furthermore, the Utrecht cases also
Page 45 and 46: Figure 3.1: Survival times after fi
Page 47 and 48: have an independent mode of inherit
Page 49 and 50: 3.9.1.5 Prognosis Prognosis for OCD
Page 51 and 52: CU/dl). Of these with low values, 2
Page 53 and 54: 3.12 Miscellaneous 3.12.1 Odds Rati
Page 55 and 56:
The disease is clinically character
Page 57 and 58:
It is interesting to notice that ev
Page 59 and 60:
4.2.2 The SAS Program Package Stati
Page 61 and 62:
5 Results of Past Studies Revisited
Page 63 and 64:
5.1.4 Causes of Death 5.1.4.1 Influ
Page 65 and 66:
5.2 Analysis of Murphy (1991) ANOVA
Page 67 and 68:
5.2.1.3 Gender Effects As mentioned
Page 69 and 70:
5.2.2.3 Gender Effects No significa
Page 71 and 72:
6.1.2 Inbreeding Four inbreeding co
Page 73 and 74:
6.1.3 Geographical Origin Countries
Page 75 and 76:
6.2.1 Data of Living Dogs Ages at w
Page 77 and 78:
Coefficient R 2 p F Coefficient R 2
Page 79 and 80:
Fig. 6.8: Lifespan (GD) of direct p
Page 81 and 82:
UC Excluded - Birth Cohorts Merged
Page 83 and 84:
Fig. 6.10: 10-Generation Wright's I
Page 85 and 86:
The individual and cumulative contr
Page 87 and 88:
6.4 Ancestor Analyses of Diseases P
Page 89 and 90:
6.4.2 Osteogenic Sarcoma 6.4.2.1 Re
Page 91 and 92:
6.4.4 Portosystemic Shunt 6.4.4.1 R
Page 93 and 94:
6.4.5.2 Dog 6844 Given that dog 684
Page 95 and 96:
6.4.5.4 Dog 6636 Dog 6636 (born 195
Page 97 and 98:
7 Discussion 7.1 Lifespan 7.1.1 Lif
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findings of the study at hand are i
Page 101 and 102:
degree. The fact that average lifes
Page 103 and 104:
first-generation progeny. The broad
Page 105 and 106:
In this model, the degree of purgin
Page 107 and 108:
7.2.2.5 Present Study No significan
Page 109 and 110:
It is interesting to consider what
Page 111 and 112:
7.3 Ethical Considerations 7.3.1 In
Page 113 and 114:
7.3.2 Decreased Lifespan The ethica
Page 115 and 116:
(Papazoglou, Monnet et al. 2002). G
Page 117 and 118:
While there are currently no heredi
Page 119 and 120:
7.5 Future Research Prospects 7.5.1
Page 121 and 122:
8 References Ackerman, L. (1999). T
Page 123 and 124:
Deeb, B. and N. Wolf (1994). "Study
Page 125 and 126:
Kealy, R. D., D. F. Lawler, et al.
Page 127 and 128:
Rothuizen, J. (2002). Molecular Gen
Page 129 and 130:
Walker, H. (1896). Der Irish Wolfho
Page 131:
ID DR DA DR10 DA10 GR GA GR10 GA10
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