Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

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6.4.5 Pedigree Charts for PSS 6.4.5.1 Calculated Ancestors While the results for the first three causes of death were not particularly encouraging, the PSS data comparisons showed enough promise to put the relations within this population into a pedigree chart. This resulted in figure 6.13 below: 6360 6636 7096 6533 6844 7084 7086 7080 7097 7594 8420 6544 7191 7409 9325 11392 9249 7383 7798 7571 8251 8875 7385 7796 8000 7474 7719 7560 7509 9861 8608 8002 7978 7344 7910 6819 7791 7960 7510 7152 7814 8139 9103 10393 11055 8847 8606 8279 8915 9795 8929 8972 9689 11701 10369 10362 9840 11730 12096 12386 Fig. 6.13: Pedigree chart of main ancestors of PSS cases (chapter 6.4.4.2). Dogs mentioned in table 6.26 are marked grey. Note that individuals 8153 and 8382 have been omitted from this graph. 8153 is a great-grandson of 6360, while 8382 would have to be tracked back behind 5838 to find common ancestors with the population in this graph. Also note that 11'392 is the only individual to appear in the results for both the reference and the affected shunt population. Given that PSS follows a simple autosomal recessive mode of inheritance (see chapter 3.2.3), the results of this analysis give way to several possible interpretations. 86
6.4.5.2 Dog 6844 Given that dog 6844 explains 6.1% of the genetic variability of all PSS cases, it is obvious that its role in the graph should be analysed. This is done in figure 6.14 below. 6360 6636 6533 6844 7084 7086 7080 7097 7594 7096 8420 6544 7409 9325 11392 9249 10393 7571 7383 7798 8251 8875 11055 8847 7385 7796 8000 7474 7719 7560 8279 8606 7509 9861 8915 9795 8608 8002 7978 7344 7910 8929 7960 6819 7791 7510 7152 8972 7191 7814 8139 9103 9689 11701 10369 10362 9840 11730 12096 12386 Fig. 6.14: Direct descendants of dog 6844 Figure 6.14 shows that dog 6844 is directly related to all but one important PSS ancestors in the lower half of the pedigree chart, but does in itself not explain the important ancestors in the upper right area of the chart (also see figure 6.16). Within the population marked grey, four double-ups on this individual can be found. 87
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Aus der Abteilung Tierhaltung und T
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Omnia mors poscit - lex est, non po
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Table of Contents Acknowledgements
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1 Abstract/Summary This study inves
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1.2.3 Own Data A worldwide pedigree
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Due to the frequent bottlenecks dur
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2 Introduction "It is impossible to
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3 Literature Review Several disease
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previous results (Comfort 1960). No
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the average ages were significantly
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3.2 Intrahepatic Portosystemic Shun
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Conservative therapy is also indica
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mitochondrial hyperplasia, disrupti
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there are marked individual differe
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3.3.2 Epizootology Numbers publishe
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2002). On the molecular level, the
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3.4.2 Epizootology In past studies
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3.5.1.3 Diagnosis The history and c
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3.5.2 Epizootology A prospective st
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Differential diagnoses include recu
Page 41 and 42: 3.7.1.3 Diagnosis The definite diag
Page 43 and 44: Furthermore, the Utrecht cases also
Page 45 and 46: Figure 3.1: Survival times after fi
Page 47 and 48: have an independent mode of inherit
Page 49 and 50: 3.9.1.5 Prognosis Prognosis for OCD
Page 51 and 52: CU/dl). Of these with low values, 2
Page 53 and 54: 3.12 Miscellaneous 3.12.1 Odds Rati
Page 55 and 56: The disease is clinically character
Page 57 and 58: It is interesting to notice that ev
Page 59 and 60: 4.2.2 The SAS Program Package Stati
Page 61 and 62: 5 Results of Past Studies Revisited
Page 63 and 64: 5.1.4 Causes of Death 5.1.4.1 Influ
Page 65 and 66: 5.2 Analysis of Murphy (1991) ANOVA
Page 67 and 68: 5.2.1.3 Gender Effects As mentioned
Page 69 and 70: 5.2.2.3 Gender Effects No significa
Page 71 and 72: 6.1.2 Inbreeding Four inbreeding co
Page 73 and 74: 6.1.3 Geographical Origin Countries
Page 75 and 76: 6.2.1 Data of Living Dogs Ages at w
Page 77 and 78: Coefficient R 2 p F Coefficient R 2
Page 79 and 80: Fig. 6.8: Lifespan (GD) of direct p
Page 81 and 82: UC Excluded - Birth Cohorts Merged
Page 83 and 84: Fig. 6.10: 10-Generation Wright's I
Page 85 and 86: The individual and cumulative contr
Page 87 and 88: 6.4 Ancestor Analyses of Diseases P
Page 89 and 90: 6.4.2 Osteogenic Sarcoma 6.4.2.1 Re
Page 91: 6.4.4 Portosystemic Shunt 6.4.4.1 R
Page 95 and 96: 6.4.5.4 Dog 6636 Dog 6636 (born 195
Page 97 and 98: 7 Discussion 7.1 Lifespan 7.1.1 Lif
Page 99 and 100: findings of the study at hand are i
Page 101 and 102: degree. The fact that average lifes
Page 103 and 104: first-generation progeny. The broad
Page 105 and 106: In this model, the degree of purgin
Page 107 and 108: 7.2.2.5 Present Study No significan
Page 109 and 110: It is interesting to consider what
Page 111 and 112: 7.3 Ethical Considerations 7.3.1 In
Page 113 and 114: 7.3.2 Decreased Lifespan The ethica
Page 115 and 116: (Papazoglou, Monnet et al. 2002). G
Page 117 and 118: While there are currently no heredi
Page 119 and 120: 7.5 Future Research Prospects 7.5.1
Page 121 and 122: 8 References Ackerman, L. (1999). T
Page 123 and 124: Deeb, B. and N. Wolf (1994). "Study
Page 125 and 126: Kealy, R. D., D. F. Lawler, et al.
Page 127 and 128: Rothuizen, J. (2002). Molecular Gen
Page 129 and 130: Walker, H. (1896). Der Irish Wolfho
Page 131: ID DR DA DR10 DA10 GR GA GR10 GA10
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