Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

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6 Analysis of the Present Data 6.1 Population Structure and Genetics 6.1.1 Birth Cohorts As mentioned in chapter 4.1, the population used for the study at hand consisted of n=50'822 Irish Wolfhounds born between 1862 and 2005 (23'219 males / 27'101 females / 502 unknown). There were significantly fewer males than females in the data (p
6.1.2 Inbreeding Four inbreeding coefficients were calculated for all dogs: Wright's Inbreeding Coefficients for 5, 10 and 20 generations, and Meuwissen's inbreeding coefficients back to the beginning of the available data. The distribution of inbreeding coefficients was analysed by class and year of birth. Results are given in table and figure 6.2 below. Figure 6.3 and 6.4 on the next page show the development of Wright's and Meuwissen's inbreeding coefficients in the population over time. COI Class 5 Generations 10 Generations 20 Generations Meuwissen up to 0.05 27002 3114 2452 2469 0.05 to 0.1 11236 6472 679 584 0.1 to 0.15 6199 13837 1663 1537 0.15 to 0.2 3933 13948 3206 1681 0.2 to 0.25 1260 7280 10800 3447 0.25 to 0.3 871 3869 16804 7886 0.3 to 0.35 231 1556 8828 17842 0.35 to 0.4 60 550 4372 9293 0.4 to 0.45 26 145 1419 4297 0.45 to 0.5 4 41 503 1439 0.5 to 0.55 0 10 75 296 above 0.55 0 0 21 51 Table 6.2: Distribution of different inbreeding coefficient values in the Irish Wolfhound population (n=50'822 dogs). Different COI Definitions - All Dogs (n=50'822) 30000 25000 Number of Dogs 20000 15000 10000 5 Generations 10 Generations 20 Generations Meuw issen 5000 0 up to 0.05 0.05 to 0.1 0.1 to 0.15 0.15 to 0.2 0.2 to 0.25 0.25 to 0.3 0.3 to 0.35 0.35 to 0.4 0.4 to 0.45 0.45 to 0.5 0.5 to 0.55 above 0.55 COI Class Fig. 6.2: Graphical rendering of Table 6.2 above 65
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Aus der Abteilung Tierhaltung und T
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Omnia mors poscit - lex est, non po
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Table of Contents Acknowledgements
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1 Abstract/Summary This study inves
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1.2.3 Own Data A worldwide pedigree
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Due to the frequent bottlenecks dur
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2 Introduction "It is impossible to
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3 Literature Review Several disease
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previous results (Comfort 1960). No
Page 19 and 20: the average ages were significantly
Page 21 and 22: 3.2 Intrahepatic Portosystemic Shun
Page 23 and 24: Conservative therapy is also indica
Page 25 and 26: mitochondrial hyperplasia, disrupti
Page 27 and 28: there are marked individual differe
Page 29 and 30: 3.3.2 Epizootology Numbers publishe
Page 31 and 32: 2002). On the molecular level, the
Page 33 and 34: 3.4.2 Epizootology In past studies
Page 35 and 36: 3.5.1.3 Diagnosis The history and c
Page 37 and 38: 3.5.2 Epizootology A prospective st
Page 39 and 40: Differential diagnoses include recu
Page 41 and 42: 3.7.1.3 Diagnosis The definite diag
Page 43 and 44: Furthermore, the Utrecht cases also
Page 45 and 46: Figure 3.1: Survival times after fi
Page 47 and 48: have an independent mode of inherit
Page 49 and 50: 3.9.1.5 Prognosis Prognosis for OCD
Page 51 and 52: CU/dl). Of these with low values, 2
Page 53 and 54: 3.12 Miscellaneous 3.12.1 Odds Rati
Page 55 and 56: The disease is clinically character
Page 57 and 58: It is interesting to notice that ev
Page 59 and 60: 4.2.2 The SAS Program Package Stati
Page 61 and 62: 5 Results of Past Studies Revisited
Page 63 and 64: 5.1.4 Causes of Death 5.1.4.1 Influ
Page 65 and 66: 5.2 Analysis of Murphy (1991) ANOVA
Page 67 and 68: 5.2.1.3 Gender Effects As mentioned
Page 69: 5.2.2.3 Gender Effects No significa
Page 73 and 74: 6.1.3 Geographical Origin Countries
Page 75 and 76: 6.2.1 Data of Living Dogs Ages at w
Page 77 and 78: Coefficient R 2 p F Coefficient R 2
Page 79 and 80: Fig. 6.8: Lifespan (GD) of direct p
Page 81 and 82: UC Excluded - Birth Cohorts Merged
Page 83 and 84: Fig. 6.10: 10-Generation Wright's I
Page 85 and 86: The individual and cumulative contr
Page 87 and 88: 6.4 Ancestor Analyses of Diseases P
Page 89 and 90: 6.4.2 Osteogenic Sarcoma 6.4.2.1 Re
Page 91 and 92: 6.4.4 Portosystemic Shunt 6.4.4.1 R
Page 93 and 94: 6.4.5.2 Dog 6844 Given that dog 684
Page 95 and 96: 6.4.5.4 Dog 6636 Dog 6636 (born 195
Page 97 and 98: 7 Discussion 7.1 Lifespan 7.1.1 Lif
Page 99 and 100: findings of the study at hand are i
Page 101 and 102: degree. The fact that average lifes
Page 103 and 104: first-generation progeny. The broad
Page 105 and 106: In this model, the degree of purgin
Page 107 and 108: 7.2.2.5 Present Study No significan
Page 109 and 110: It is interesting to consider what
Page 111 and 112: 7.3 Ethical Considerations 7.3.1 In
Page 113 and 114: 7.3.2 Decreased Lifespan The ethica
Page 115 and 116: (Papazoglou, Monnet et al. 2002). G
Page 117 and 118: While there are currently no heredi
Page 119 and 120: 7.5 Future Research Prospects 7.5.1
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8 References Ackerman, L. (1999). T
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Deeb, B. and N. Wolf (1994). "Study
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Kealy, R. D., D. F. Lawler, et al.
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Rothuizen, J. (2002). Molecular Gen
Page 129 and 130:
Walker, H. (1896). Der Irish Wolfho
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ID DR DA DR10 DA10 GR GA GR10 GA10
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