Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

Table of Contents
Acknowledgements .....................................................................................................v
1 Abstract/Summary............................................................................................... 1
1.1 Literature Review (chapter 3) ....................................................................... 1
1.2 Lifespan, Causes of Death, Genetics (chapters 4 to 6)................................ 2
1.3 Discussion and Conclusions (chapter 7) ...................................................... 4
2 Introduction.......................................................................................................... 7
3 Literature Review ................................................................................................ 9
3.1 Lifespan in General ...................................................................................... 9
3.2 Intrahepatic Portosystemic Shunt (PSS) .................................................... 15
3.3 Dilatative Cardiomyopathy (DCM).............................................................. 18
3.4 Osteogenic Sarcoma (OS) ......................................................................... 24
3.5 Gastric Dilation and Volvulus (GDV) .......................................................... 28
3.6 Rhinitis/Bronchopneumonia Syndrome – PCD........................................... 31
3.7 Juvenile Fibrocartilaginous Embolism (FCE).............................................. 34
3.8 Epilepsy...................................................................................................... 37
3.9 Osteochondrosis (OC)................................................................................ 41
3.10 Von Willebrand’s Disease (vWD) ............................................................... 43
3.11 Progressive Retinal Atrophy (PRA) ............................................................ 45
3.12 Miscellaneous............................................................................................. 47
3.13 Clinical Reference Values .......................................................................... 50
4 Dogs, Materials and Methods............................................................................ 52
4.1 Dogs........................................................................................................... 52
4.2 Software ..................................................................................................... 52
4.3 Definition of Causes of Death..................................................................... 54
4.4 Definition of Right Censored Data.............................................................. 54
5 Results of Past Studies Revisited...................................................................... 55
5.1 Re-analysis of Bernardi (1986) and Prokopenko (1998) ............................ 55
5.2 Analysis of Murphy (1991).......................................................................... 59
6 Analysis of the Present Data ............................................................................. 64
6.1 Population Structure and Genetics............................................................. 64
6.2 Lifespan...................................................................................................... 68
6.3 Population Genetics of Dogs Born 1965 and After..................................... 76
6.4 Ancestor Analyses of Diseases Presumed Hereditary ............................... 81
7 Discussion ......................................................................................................... 91
7.1 Lifespan...................................................................................................... 91
7.2 Population Genetics ................................................................................... 96
7.3 Ethical Considerations...............................................................................105
7.4 Future Prospects in Breeding....................................................................110
7.5 Future Research Prospects.......................................................................113
8 References .......................................................................................................115
9 Appendix ..........................................................................................................124
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