Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

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6.4.1 Dilatative Cardiomyopathy 6.4.1.1 Reference Population ID Rank sex YoB Contribution Cumulative Progeny Country 5838 1 m 1951 0.2533 0.2533 15 US to UK 4732 2 m 1939 0.1970 0.4503 10 UK 4703 3 f 1939 0.1029 0.5532 4 UK 4605 4 f 1938 0.0772 0.6304 4 UK 5538 5 m 1949 0.0764 0.7068 10 US 5184 6 m 1944 0.0687 0.7755 3 UK 5252 7 f 1945 0.0407 0.8162 2 IRL 4681 8 f 1938 0.0302 0.8464 2 UK 4475 9 f 1937 0.0240 0.8704 1 UK 4820 10 f 1939 0.0197 0.8901 3 UK 6476 11 m 1958 0.0172 0.9073 18 US 6620 12 f 1959 0.0122 0.9195 13 US 5385 13 m 1947 0.0090 0.9285 5 US 5045 14 m 1943 0.0083 0.9368 6 US 4794 15 m 1939 0.0066 0.9434 5 US 5273 16 f 1946 0.0054 0.9488 1 UK 5541 17 f 1949 0.0040 0.9528 2 US 6378 18 f 1957 0.0034 0.9562 1 IRL 5548 19 m 1949 0.0029 0.9591 1 IRL 5117 20 f 1944 0.0029 0.9620 3 US Table 6.19: Reference population results for DCM. Reading is analogous to table 6.16. 6.4.1.2 Affected Dogs ID Rank sex YoB Contribution Cumulative Progeny Country 5838 1 m 1951 0.1668 0.1668 14 US to UK 6261 2 m 1955 0.0753 0.2421 9 UK 5561 3 f 1949 0.0641 0.3062 4 UK 5349 4 f 1946 0.0586 0.3648 3 UK 7978 5 m 1967 0.0332 0.3980 13 UK 8251 6 f 1968 0.0312 0.4292 6 IRL 8847 7 m 1969 0.0286 0.4578 22 UK 5510 8 f 1948 0.0275 0.4853 2 UK 5538 9 m 1949 0.0219 0.5072 10 US 6707 10 m 1960 0.0187 0.5259 13 UK 6660 11 f 1960 0.0175 0.5434 6 IRL 6661 12 f 1960 0.0149 0.5583 7 IRL to UK 6620 13 f 1959 0.0146 0.5729 11 US 7174 14 f 1963 0.0138 0.5867 2 UK 6744 15 f 1961 0.0117 0.5984 9 IRL 6180 16 f 1955 0.0115 0.6099 5 IRL 6100 17 m 1954 0.0114 0.6213 4 IRL 8444 18 f 1968 0.0108 0.6321 10 UK 7791 19 m 1966 0.0106 0.6427 7 UK 6755 20 m 1961 0.0096 0.6523 10 IRL Table 6.20: Affected population results for DCM. Reading is analogous to table 6.16. 82
6.4.2 Osteogenic Sarcoma 6.4.2.1 Reference Population ID Rank sex YoB Contribution Cumulative Progeny Country 5838 1 m 1951 0.2387 0.2387 15 US to UK 4732 2 m 1939 0.1921 0.4308 10 UK 4703 3 f 1939 0.0990 0.5298 4 UK 4605 4 f 1938 0.0745 0.6043 4 UK 5538 5 m 1949 0.0639 0.6682 9 US 5184 6 m 1944 0.0639 0.7321 3 UK 5252 7 f 1945 0.0416 0.7737 2 IRL 4681 8 f 1938 0.0313 0.8050 2 UK 4475 9 f 1937 0.0229 0.8279 1 UK 6476 10 m 1958 0.0216 0.8495 19 US 6874 11 f 1961 0.0184 0.8679 6 UK 4820 12 f 1939 0.0164 0.8843 3 UK 6620 13 f 1959 0.0149 0.8992 12 US 5385 14 m 1947 0.0106 0.9098 5 US 5045 15 m 1943 0.0100 0.9198 6 US 4794 16 m 1939 0.0078 0.9276 5 US 5273 17 f 1946 0.0056 0.9332 1 UK 5541 18 f 1949 0.0050 0.9382 2 US 6998 19 f 1962 0.0045 0.9427 1 UK 6378 20 f 1957 0.0043 0.9470 1 IRL Table 6.21: Reference population results for OS. Reading is analogous to table 6.16. 6.4.2.2 Affected Dogs ID Rank sex YoB Contribution Cumulative Progeny Country 5838 1 m 1951 0.1929 0.1929 14 US to UK 6261 2 m 1955 0.0777 0.2706 9 UK 5561 3 f 1949 0.0720 0.3426 4 UK 5349 4 f 1946 0.0616 0.4042 3 UK 6135 5 f 1954 0.0329 0.4371 11 UK 5510 6 f 1948 0.0303 0.4674 2 UK 6476 7 m 1958 0.0289 0.4963 16 US 6707 8 m 1960 0.0269 0.5232 13 US 5538 9 m 1949 0.0263 0.5495 10 US 8251 10 f 1968 0.0245 0.5740 5 IRL 6620 11 f 1959 0.0218 0.5958 11 US 7326 12 m 1964 0.0206 0.6164 18 IRL 7002 13 m 1962 0.0178 0.6342 15 UK 8444 14 f 1968 0.0157 0.6499 10 UK 7052 15 m 1963 0.0146 0.6645 15 IRL 6744 16 f 1961 0.0114 0.6759 8 IRL 5625 17 m 1950 0.0113 0.6872 4 IRL 6661 18 f 1960 0.0108 0.6980 7 IRL to UK 7068 19 f 1963 0.0093 0.7073 3 UK 5488 20 f 1948 0.0082 0.7155 3 UK Table 6.22: Affected population results for OS. Reading is analogous to table 6.16. 83
Page 1 and 2:
Aus der Abteilung Tierhaltung und T
Page 3 and 4:
Omnia mors poscit - lex est, non po
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Table of Contents Acknowledgements
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1 Abstract/Summary This study inves
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1.2.3 Own Data A worldwide pedigree
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Due to the frequent bottlenecks dur
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2 Introduction "It is impossible to
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3 Literature Review Several disease
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previous results (Comfort 1960). No
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the average ages were significantly
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3.2 Intrahepatic Portosystemic Shun
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Conservative therapy is also indica
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mitochondrial hyperplasia, disrupti
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there are marked individual differe
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3.3.2 Epizootology Numbers publishe
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2002). On the molecular level, the
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3.4.2 Epizootology In past studies
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3.5.1.3 Diagnosis The history and c
Page 37 and 38: 3.5.2 Epizootology A prospective st
Page 39 and 40: Differential diagnoses include recu
Page 41 and 42: 3.7.1.3 Diagnosis The definite diag
Page 43 and 44: Furthermore, the Utrecht cases also
Page 45 and 46: Figure 3.1: Survival times after fi
Page 47 and 48: have an independent mode of inherit
Page 49 and 50: 3.9.1.5 Prognosis Prognosis for OCD
Page 51 and 52: CU/dl). Of these with low values, 2
Page 53 and 54: 3.12 Miscellaneous 3.12.1 Odds Rati
Page 55 and 56: The disease is clinically character
Page 57 and 58: It is interesting to notice that ev
Page 59 and 60: 4.2.2 The SAS Program Package Stati
Page 61 and 62: 5 Results of Past Studies Revisited
Page 63 and 64: 5.1.4 Causes of Death 5.1.4.1 Influ
Page 65 and 66: 5.2 Analysis of Murphy (1991) ANOVA
Page 67 and 68: 5.2.1.3 Gender Effects As mentioned
Page 69 and 70: 5.2.2.3 Gender Effects No significa
Page 71 and 72: 6.1.2 Inbreeding Four inbreeding co
Page 73 and 74: 6.1.3 Geographical Origin Countries
Page 75 and 76: 6.2.1 Data of Living Dogs Ages at w
Page 77 and 78: Coefficient R 2 p F Coefficient R 2
Page 79 and 80: Fig. 6.8: Lifespan (GD) of direct p
Page 81 and 82: UC Excluded - Birth Cohorts Merged
Page 83 and 84: Fig. 6.10: 10-Generation Wright's I
Page 85 and 86: The individual and cumulative contr
Page 87: 6.4 Ancestor Analyses of Diseases P
Page 91 and 92: 6.4.4 Portosystemic Shunt 6.4.4.1 R
Page 93 and 94: 6.4.5.2 Dog 6844 Given that dog 684
Page 95 and 96: 6.4.5.4 Dog 6636 Dog 6636 (born 195
Page 97 and 98: 7 Discussion 7.1 Lifespan 7.1.1 Lif
Page 99 and 100: findings of the study at hand are i
Page 101 and 102: degree. The fact that average lifes
Page 103 and 104: first-generation progeny. The broad
Page 105 and 106: In this model, the degree of purgin
Page 107 and 108: 7.2.2.5 Present Study No significan
Page 109 and 110: It is interesting to consider what
Page 111 and 112: 7.3 Ethical Considerations 7.3.1 In
Page 113 and 114: 7.3.2 Decreased Lifespan The ethica
Page 115 and 116: (Papazoglou, Monnet et al. 2002). G
Page 117 and 118: While there are currently no heredi
Page 119 and 120: 7.5 Future Research Prospects 7.5.1
Page 121 and 122: 8 References Ackerman, L. (1999). T
Page 123 and 124: Deeb, B. and N. Wolf (1994). "Study
Page 125 and 126: Kealy, R. D., D. F. Lawler, et al.
Page 127 and 128: Rothuizen, J. (2002). Molecular Gen
Page 129 and 130: Walker, H. (1896). Der Irish Wolfho
Page 131: ID DR DA DR10 DA10 GR GA GR10 GA10
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