Lifespan and Causes of Death in the Irish Wolfhound - Vetsuisse ...

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6.2.2.2 Influence of Cohort Bias To assess the influence of Cohort Bias on the percentual frequency of causes of death, the same analysis was carried out in the data that was subject to Cohort Bias. Results are given in table 6.7 below: Cause of Death n % Mean age ± SD All Dogs 166 100.00 5.71 ± 2.28 GDV 16 9.64 5.86 ± 2.60 DCM 40 24.10 5.99 ± 1.83 OS 28 16.87 6.37 ± 1.76 OCa 26 15.66 6.20 ± 2.15 II 11 6.63 5.76 ± 2.50 Accident 24 14.46 3.73 ± 2.30 OGD 21 12.65 5.77 ± 2.52 Table 6.7: Dogs subjected to Cohort Bias Neither the overall distribution of causes of death (p=0.62, chi-square=4.42) nor any of the individual disease distributions did vary significantly between tables 6.6 and 6.7. On the other hand, age of death varied significantly between the two populations as expected (p
Coefficient R 2 p F Coefficient R 2 p F 5 Gens 0.000037 0.82 0.05 20 Gens 0.0013 0.18 1.81 10 Gens 0.000045 0.80 0.06 Meuwissen 0.0026 0.06 3.53 Table 6.9: Influence of inbreeding on lifespan (n=1423; DF=1; type III SS) Age at Death vs. Inbreeding (Meuwissen) 16 14 12 Age at Death 10 8 6 4 2 0 0 0.1 0.2 0.3 0.4 0.5 0.6 Meuwissen's Inbreeding Coefficient Fig. 6.7: Diagram of measured lifespan and Meuwissen's Inbreeding Coefficients, adjusted for Cohort Bias. No significant correlation was found. 6.2.3.2 Causes of Death Since an association of increasing inbreeding level with DCM in Irish Wolfhounds has been reported in the literature (Broschk 2004), this possibility was also analysed in our population. Inbreeding levels in the population affected with DCM and the randomly chosen reference population (see chapter 4.5) were not significantly different for 5- and 10-generation Wright's inbreeding coefficients as well as Meuwissen's inbreeding coefficients. On the other hand, 20-generation Wright's inbreeding coefficients were significantly lower in dogs affected with DCM than in dogs without DCM, but R 2 remains very low (0.26 ± 0.09 vs. 0.28 ± 0.07; p=0.033, R 2 =0.0014, F=4.54; Type III SS). 71
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Aus der Abteilung Tierhaltung und T
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Omnia mors poscit - lex est, non po
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Table of Contents Acknowledgements
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1 Abstract/Summary This study inves
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1.2.3 Own Data A worldwide pedigree
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Due to the frequent bottlenecks dur
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2 Introduction "It is impossible to
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3 Literature Review Several disease
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previous results (Comfort 1960). No
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the average ages were significantly
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3.2 Intrahepatic Portosystemic Shun
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Conservative therapy is also indica
Page 25 and 26: mitochondrial hyperplasia, disrupti
Page 27 and 28: there are marked individual differe
Page 29 and 30: 3.3.2 Epizootology Numbers publishe
Page 31 and 32: 2002). On the molecular level, the
Page 33 and 34: 3.4.2 Epizootology In past studies
Page 35 and 36: 3.5.1.3 Diagnosis The history and c
Page 37 and 38: 3.5.2 Epizootology A prospective st
Page 39 and 40: Differential diagnoses include recu
Page 41 and 42: 3.7.1.3 Diagnosis The definite diag
Page 43 and 44: Furthermore, the Utrecht cases also
Page 45 and 46: Figure 3.1: Survival times after fi
Page 47 and 48: have an independent mode of inherit
Page 49 and 50: 3.9.1.5 Prognosis Prognosis for OCD
Page 51 and 52: CU/dl). Of these with low values, 2
Page 53 and 54: 3.12 Miscellaneous 3.12.1 Odds Rati
Page 55 and 56: The disease is clinically character
Page 57 and 58: It is interesting to notice that ev
Page 59 and 60: 4.2.2 The SAS Program Package Stati
Page 61 and 62: 5 Results of Past Studies Revisited
Page 63 and 64: 5.1.4 Causes of Death 5.1.4.1 Influ
Page 65 and 66: 5.2 Analysis of Murphy (1991) ANOVA
Page 67 and 68: 5.2.1.3 Gender Effects As mentioned
Page 69 and 70: 5.2.2.3 Gender Effects No significa
Page 71 and 72: 6.1.2 Inbreeding Four inbreeding co
Page 73 and 74: 6.1.3 Geographical Origin Countries
Page 75: 6.2.1 Data of Living Dogs Ages at w
Page 79 and 80: Fig. 6.8: Lifespan (GD) of direct p
Page 81 and 82: UC Excluded - Birth Cohorts Merged
Page 83 and 84: Fig. 6.10: 10-Generation Wright's I
Page 85 and 86: The individual and cumulative contr
Page 87 and 88: 6.4 Ancestor Analyses of Diseases P
Page 89 and 90: 6.4.2 Osteogenic Sarcoma 6.4.2.1 Re
Page 91 and 92: 6.4.4 Portosystemic Shunt 6.4.4.1 R
Page 93 and 94: 6.4.5.2 Dog 6844 Given that dog 684
Page 95 and 96: 6.4.5.4 Dog 6636 Dog 6636 (born 195
Page 97 and 98: 7 Discussion 7.1 Lifespan 7.1.1 Lif
Page 99 and 100: findings of the study at hand are i
Page 101 and 102: degree. The fact that average lifes
Page 103 and 104: first-generation progeny. The broad
Page 105 and 106: In this model, the degree of purgin
Page 107 and 108: 7.2.2.5 Present Study No significan
Page 109 and 110: It is interesting to consider what
Page 111 and 112: 7.3 Ethical Considerations 7.3.1 In
Page 113 and 114: 7.3.2 Decreased Lifespan The ethica
Page 115 and 116: (Papazoglou, Monnet et al. 2002). G
Page 117 and 118: While there are currently no heredi
Page 119 and 120: 7.5 Future Research Prospects 7.5.1
Page 121 and 122: 8 References Ackerman, L. (1999). T
Page 123 and 124: Deeb, B. and N. Wolf (1994). "Study
Page 125 and 126: Kealy, R. D., D. F. Lawler, et al.
Page 127 and 128:
Rothuizen, J. (2002). Molecular Gen
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Walker, H. (1896). Der Irish Wolfho
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ID DR DA DR10 DA10 GR GA GR10 GA10
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