Alternatives for Brominated Flame Retardants - Miljøstyrelsen

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2UDO LD 50 Rat oral larger than 34,600 mg/kg [4,5,6].
LD 50 Rabbit percutaneous larger than 2,000 mg/kg [4].
Rabbits fed daily up to 150 mg/kg for 4 weeks showed no pathologic
changes [4].
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Skin-rabbit LDLo: 2 mg/kg.
Inhalation in humans causes inflammation of upper and lower respiratory
tract [4].
Rats and rabbits exposed to antimony trioxide (90-125 mg antimony
trioxide/m 3 during 100 h/month) for periods of up to 14 months, developed
in addition to pneumonitis, also lipoid pneumonia, fibrous
thickening of alveolar walls, and focal fibrosis. Rabbits appeared to
be more susceptible than rats. [4].
Guinea pigs exposed to a dust concentration of antimony trioxide of
45.4 mg/m 3 of air, for 2 h daily 7 days a week for the first 3 weeks,
later for 3 h daily; which corresponded to an estimated daily retention
of 1.6 mg. All the animals showed extensive interstitial pneumonitis,
and 4 died during the period of exposure. No cardiac lesions,
as evidenced by the electrocardiogram, were observed. Fatty degeneration
of the liver in 11 out of 15 guinea pigs having 138 or more
hours of exposure was recorded. The blood picture showed a decrease
in total white cells. [4].
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Contact with skin caused dermatitis [4], and the substance is regarded
as moderately irritating [6].
(\H,UULWDWLRQ Contact with eyes causes conjunctivitis [4].
,UULWDWLRQRI5HVSLUDWRU\7UDFW Ingestion can cause irritation of the mouth and nose [4].
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