Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
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♦Tricresyl phosphate was not mutagenic in Salmonella typhimurium<br />
strains TA98, TA100, TA1535, or TA1537, nor did it induce chromosomal<br />
aberrations or sister chromatid exchanges in cultured Chinese<br />
hamster ovary cells. These in vitro assays were all conducted<br />
with and without exogenous metabolic activation. [7].<br />
No relevant data found<br />
No relevant data found<br />
No relevant data found<br />
♦In 2-year feeding studies there were no evidence of carcinogenic<br />
effects of tricresyl phosphate in male or female F344/N rats treated<br />
at 75, 150, or 300 ppm. There was no evidence of carcinogenic activity<br />
of tricresyl phosphate in male or female B6C3F1 mice treated at<br />
60, 125, or 250 ppm. [7].<br />
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♦The reproductive effects of tricresyl phosphate (TCP) were investigated<br />
in Long Evans rats . Twelve male rats/dose group were given<br />
0, 100, or 200 mg/kg TCP in corn oil (10 ml/kg body wt) by<br />
gavage once/day, 7 days/wk <strong>for</strong> 56 days prior to breeding and<br />
throughout the 10 day breeding period. Twenty four female rats/dose<br />
group received 0, 200, or 400 mg/kg TCP in corn oil (10 ml/kg body<br />
wt) <strong>for</strong> 14 days prior to breeding, and throughout breeding, gestation<br />
and lactation until the pups were weaned on day 21.<br />
Control groups were given corn oil only. The results show that male<br />
rats treated with 200 mg/kg TCP had reduced sperm concentration,<br />
motility, and velocity (65, 4, and 5% of control, respectively). There<br />
was a dose-dependent increase in abnormal sperm morphology in<br />
both the 100 mg/kg and 200 mg/kg treated males. TCP did not have<br />
an adverse effect on mean testicular wt, but epididymal weights were<br />
reduced in the 200 mg/kg dose group males. The % of spermpositive<br />
females <strong>for</strong> TCP-exposed pairs was not different from that<br />
of controls. [4].<br />
No relevant data found<br />
No relevant data found<br />
No relevant data found<br />
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