Alternatives for Brominated Flame Retardants - Miljøstyrelsen

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Melamine seems to be only mildly toxic if ingested by animals. There is not sufficient data to predict acute
toxicity from dermal application in humans. The available test data do not show evidence of irritation, cancer
induction or mutageneity by melamine.
Based on animal tests it seems there is a risk of formation of stones in the urinary bladder.
Dermatitis has been reported from melamine formaldehyde resins and glues. Probably these cases were chiefly
due to formaldehyde or intermediate reaction products of formaldehyde.
The LD50 for application of melamine on rabbit skin is found in one study to be slightly larger than 1 mg/kg
(1 mg/kg implicates a high risk of adverse effects on skin of humans).
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The reviewed limited toxicity data show little aquatic toxicity of melamine. A 96h algae EC 50 is 940 mg/l, a
21d NOEC for Daphnia 18 mg/l.
The available BCF and the pK a values indicate that the bioaccumulation of this compound is low in the natural
pH range (pH 6-8).
The available biodegradation data indicates that this compound is persistent both under aerobic and anaerobic
conditions.