Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
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♦9 out of 10 rats died when exposed <strong>for</strong> 1 hour to 4.3 mg/l red<br />
phosphorus, and 2 out of 10 died when exposed to 1.5 mg/l <strong>for</strong> 4<br />
hours [6].<br />
Inhalation of phosphorus vapour (allotropic <strong>for</strong>m not specified) by<br />
rabbits <strong>for</strong> 30 min daily at a concentration of 150-160 mg/m 3 led to<br />
decreased haemoglobin counts [4].<br />
Rabbits and rats were exposed to single doses of smoke from pyrotechnic<br />
mixtures containing red phosphorus. The survivors were observed<br />
<strong>for</strong> up to 14 days. Most of the histological changes observed<br />
were found in the respiratory tract, including abnormalities in the<br />
alveolitis and, in a few cases, frank pneumonia. [4].<br />
Mice and rats were exposed to the smoke produced by ignition of a<br />
red phosphorus pyrotechnic composition, 1 hour/day, 5 days/week,<br />
at two different dose levels, together with controls. The mice received<br />
180 exposures, while the rats received 200 exposures. Guinea<br />
pigs also underwent 200 exposures at the lower concentration, but<br />
all animals exposed at the higher concentration died during or immediately<br />
after the first dose. Growth of the test groups of mice and<br />
rats was depressed during the exposure period. Organ specific toxicity<br />
appeared not to be present in rats and was generally confined to<br />
the respiratory tract of the mice and the guinea pigs. [4].<br />
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Rats injected subcutaneously with 0.05 mg/kg of yellow phosphorus<br />
per day developed bone changes after administration of 50 mg. [4].<br />
Subcutaneous injection of 0.2-0.4 mg/kg/day (allotropic <strong>for</strong>m not<br />
specified) in dogs caused delayed deaths within a few days [4].<br />
6NLQ,UULWDWLRQ The substance (allotropic <strong>for</strong>m not specified) is corrosive [6].<br />
(\H,UULWDWLRQ The substance (allotropic <strong>for</strong>m not specified) irritates eyes [4].<br />
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Inhalation of more than 20 ppm phosphorus (allotropic <strong>for</strong>m not specified)<br />
vapours by rats (7 hours/day, 5 days/week) resulted in severe<br />
respiratory irritation [4].<br />
No relevant data found.<br />
No relevant data found.<br />
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No relevant data found.<br />
The most important manifestation of chronic phosphorus (allotropic<br />
<strong>for</strong>m not specified) poisoning is osteomyelitis of the jaw bones<br />
("phossy jaw"), which commonly begins as a dental disturbance. [4].
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