Alternatives for Brominated Flame Retardants - Miljøstyrelsen

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Severe aluminium intoxication following oral administration of aluminium
hydroxide, chloride, or sulphate to rats is characterised by
anorexia or death [4].
The effects of dietary administration of aluminium hydroxide were
examined in male Sprague-Dawley rats. Groups of 25 rats were fed a
diet containing 14,470 ppm aluminium hydroxide or a control diet
for 28 days. The mean daily aluminium dose was calculated as 302
mg/kg body weight/day. Dietary administration of aluminium hydroxide
did not induce any signs of toxicity. Clinical observations during
the 28-day treatment period and the recovery phase were similar
in control and treated rats. There were no significant changes in
haematology, clinical chemistry parameters, or organ weights.
Histopathological examination of tissues revealed no treatmentrelated
changes. Ingestion of aluminium hydroxide caused no significant
deposition of Al in bone samples. [4].
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No relevant data found.
No relevant data found.
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♦Aluminium compounds have been evaluated as non-mutagenic by
most standard methods of mutagenic assays. [4].
No relevant data found.
No relevant data found.
No relevant data found.
No relevant data found.
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No relevant data found.
♦In one study, concentrations of aluminium ranging from 500 to
1,000 ug/g body weight were added to the diets of pregnant rats from
day 6 to day 19 of gestation, when the fetuses were removed by Caesarean
section. Aluminium in the diet did not affect embryo or fetal
mortality rate, litter size, fetal body weight, or length. [4].
♦5-16 days’ exposure of mice did not lead to material toxicity, embryo/fetal
toxicity or teratogenicity [6].