Alternatives for Brominated Flame Retardants - Miljøstyrelsen

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♦Several studies concerning subcutaneous acute toxicity have been
conducted. Some of the first studies were performed with TPP prepared
from coal-tar sources containing neurotoxic impurities. Based
on recent experimental data, it is concluded that TPP is not neurotoxic
when it is administered subcutaneously [3].
Subcutaneous-monkey LDLo: 500 mg/kg [2,4,6].
Subcutaneous-cat LDLo: 300 mg/kg
Subcutaneous-rat LD0: 3,000 mg/kg bw. [3].
Subcutaneous-guinea pig LD0: 3,000 mg/kg bw. [3].
6NLQ,UULWDWLRQ Based on 4 studies it is concluded that TPP is not irritating skin [3].
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100 mg TPP administered directly in the eye of rabbits cause minimal
reversible irritation [3].
No relevant data found
♦Some people have been tested positive in TPP patch-tests [3] and
one case of skin sensitisation has been recorded [2].
An allergic reaction in a 67-year old woman to spectacle frames
containing triphenyl phosphate was reported. Patch tests with analytical
grade triphenyl phosphate in that individual indicated a reaction
at concentrations as low as 0.05%. [2].
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No relevant data found
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♦Numerous medical observations have been made on workmen employed
for several (2-10) years in the factory where TPP was produced.
No abnormal symptoms appear to have been observed, in particular
no signs of neurotoxicity. Persons with preexisting neuromuscular
disorders may be at increased risk. [2].
2UDO Oral-rat NOAL: 1,900 mg/kg repeated dose [3].
Oral administration for 3 months to rats in doses of 1,800 mg/kg and
380 mg/kg caused no deaths, and it was concluded from the normal
growth and cholinesterase activity that these doses have no cumulative
toxic effects. [2].
When administered as repeated excessive doses orally, TPP can cause
neurotoxic effects such as decreased cholinesterase activity [3].
Concerning neurotoxicity 3 studies have been conducted on hens and
chickens with an exposure time of 5-6 days. Only one of these studies
indicated signs of decreased colinesterase activity. The two others
did not indicate signs of neurotoxicity [2,3].