Alternatives for Brominated Flame Retardants - Miljøstyrelsen

2UDO Chronic feeding tests have been carried out on rats over a period of 2
years at a dietary level of 1,000 ppm and on dogs for 1 year at a level
of 30,000 ppm. Throughout the study, the general health was not
significantly different from that of the controls. At these levels microscopic
examination of the tissues revealed no abnormality attributable
to the feeding of Melamine. [4].
Body weight gain was depressed in males receiving 6,000 and
12,000 ppm but not in females [6].
When rats where fed with Melamine at a 1.0% level (10,000 ppm)
over their life-span, bladder stones with benign papillomata were
found in about 1/3 of the animals. These papillomata are interpreted
as a typical response of the rat’s bladder mucosa to the presence of a
foreign body. No disturbance of the nutrition or the general healthy
appearance of these animals was noted. [4].
In 2 studies on B6C3F mice and 2 on Fischer 344/N rats effects on
bladder after 14 days exposure have been studied. In these studies
stones were found in the urinary bladders of most male rats, as a dose-related
incidence, and in the bladders of some female rats receiving
15,000 mg/kg or more. Bladder stones were observed in both
male and female mice receiving 12,000 mg/kg or more [4,6].
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No relevant data found.
♦Dermatitis has been reported from melamine formaldehyde resins
and glues. Probably these cases were chiefly due to formaldehyde or
intermediate reaction products of formaldehyde.
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0XWDJHQLFLW\ Oral-rat TDLo: 195 g/kg/2Y [3,5].
Melamine (tested up to 5,550 µg/plate) was not mutagenic to Salmonella
typhimurium TA1535, TA1537, TA98 or TA100 in the presence
or absence of a metabolic system (S9) from the liver of
Aroclor-induced rats or hamsters. [4].
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4 Ames test studies were negative in Salmonella typhimurium at
concentrations of 0.1-5,000 µg/plate [6].
No relevant data found.
No relevant data found.
Inadequate evidence of carcinogenicity in animals.
♦IARC Cancer Review: Group 3: No data available in humans. The
agent is not classifiable as to its carcinogenicity to humans [3,4].