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Alternatives for Brominated Flame Retardants - Miljøstyrelsen

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2UDO<br />

Because aluminium is only sparingly absorbed from the gut, LD50<br />

values <strong>for</strong> aluminium ingestion are unavailable, since death occurs<br />

from intestinal blockage due to precipitated aluminium species<br />

rather than systemic aluminium toxicity [4]. The only LD50 value<br />

(>5000 mg/kg bw) found supports this [6].<br />

Antacids including aluminium hydroxide may inhibit the gastrointestinal<br />

absorption of some beta-blockers [4].<br />

'HUPDO<br />

,QKDODWLRQ<br />

No relevant data found.<br />

Animal studies show that aluminium particles, in particular stamped<br />

aluminium powder, may cause fibrosis of the lung whereas particles<br />

of aluminium compounds appear to be less reactive [4].<br />

♦On occasion workers chronically exposed to aluminium-containing<br />

dusts or fumes have developed severe pulmonary reactions [4].<br />

2WKHU5RXWHV<br />

Aluminium salts are much more toxic intravenously than by mouth<br />

to animals [4].<br />

6NLQ,UULWDWLRQ Not irritating [6].<br />

(\H,UULWDWLRQ<br />

♦One study indicates that aluminium hydroxide is not an eye irritant<br />

[6], but aluminium (dust or powder) is an eye irritant [4].<br />

,UULWDWLRQRI5HVSLUDWRU\7UDFW ♦Aluminium (dust or powder) is a respiratory irritant [4].<br />

6NLQ6HQVLWLVDWLRQ Not sensitising [6].<br />

Aluminium compounds appear to be less reactive [4].<br />

6HQVLWLVDWLRQE\,QKDODWLRQ<br />

No relevant data found.<br />

6XEFKURQLFDQG&KURQLF7R[LFLW\<br />

2EVHUYDWLRQLQKXPDQV<br />

There has been and still is much dispute about aluminium’s influence<br />

on CNS, e.g. the development of Alzheimer syndrome. Although<br />

aluminium is common in nature, and the exposure there<strong>for</strong>e rather<br />

comprehensive, the amount found in humans is rather limited [6].

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