Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
Alternatives for Brominated Flame Retardants - Miljøstyrelsen
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In workers engaged in the manufacture of aryl phosphates (including<br />
TPP and up to 20% triorthocresyl phosphate) and exposed to concentrations<br />
of aryl phosphates of 0.2 to 3.4 mg/m 3 . There was some<br />
inhibition of plasma cholinesterase, but no correlation between this<br />
effect and the degree of exposure or minor gastrointestinal or neuromuscular<br />
symptoms [2].<br />
'HUPDO Contact dermatitis due to TPP has been described [10].<br />
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Triphenyl phosphate was tested <strong>for</strong> mutagenicity in the Salmonella/microsome<br />
preincubation assay using a protocol approved by the<br />
National Toxicology Program. Triphenyl phosphate was tested at<br />
doses of 0, 100, 333, 1000, 3333 and 10,000 ug/plate in four Salmonella<br />
typhimurium strains (TA98, TA100, TA1535, and TA1537) in<br />
the presence and absence of Aroclor-induced rat or hamster liver S9.<br />
Triphenyl phosphate was negative in these tests, and the highest ineffective<br />
dose level tested (not causing the <strong>for</strong>mation of a precipitate)<br />
in any Salmonella tester strain was 1000 ug/plate. [2].<br />
♦4 AMES tests were negative [3] and WHO conclude that TPP is<br />
not mutagenic [10].<br />
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No relevant data found.<br />
No relevant data found.<br />
No relevant data found.<br />
No IARC evaluation.<br />
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One study concludes that TPP is not a development toxicant in rats<br />
[3].<br />
The NOAEL on mothers and offspring from a 90-day rat study was<br />
terminated at 690 mg/kg per day [10].<br />
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No relevant data found.<br />
No relevant data found.<br />
TPP is poorly absorbed through the intact skin but readily through<br />
guinea pig skin [2].<br />
Application of TPP on skin of rats as well as application of TPP in<br />
ethanol solution on skin of mice caused no skin irritation which leads<br />
to the conclusion that since cholinesterase is not inhibited after<br />
application, there is no dermal absorption. [2].
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