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health
these devices now enables researchers to
ask almost any research question of interest;
and to use these devices to understand
how infection proceeds, and how it can be
treated.
1. Bionumbers.
2. Genovesio et al in press
3. Genovesio, A. et al. Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for
Trypanosoma cruzi Infection. PLoS One 6, e19733, doi:10.1371/journal.pone.0019733 (2011).
4. Tsukasa et al in press
The high throughput biology team has used
these devices to screen for host pathogen
interactions in HIV 2 ; trypanosome infection 3
(such as is found in sleeping sickness and
Chagas disease); and the most common
genetic disease in caucasians, cystic
fi brosis 4 .
Apart from the technology developed,
the team has also built the majority of
infrastructure, including clean facilities.
Several Master’s and PhD students have
benefi ted from their involvement in this
novel research that offers great opportunity
for improving patient treatment, by
matching the treatment to the disease.
Commercialising this technology to
personalise high throughout biology is the
team’s long-term focus.
The printing head used to print
experiments on glass wafers.
Seen here are images of the actin skeleton within cells surrounding the
DNA packed nucleus.
35 PROJECT HIGHLIGHTS