Abstracts - Association for Chemoreception Sciences

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For patients not involved in litigation, we found significant relationships between odor ID and ratings (p
normal. Allergy skin test was positive for garlic and onion. Nose plug and counter stimulation with peppermint prevented the onset of migraine. Conclusion: This is the first report of migraines triggered by more than one alliaceous compound in the same individual. Possible mechanisms include odor induced: emotional change; vasomotor instability; trigeminal induced neurogenic inflammation; and allergic response. In alliaceous and odor-induced migraines, a trial of counter stimulation and nose plugs is warranted. #P11 POSTER SESSION I: MULTIMODAL RECEPTION; CHEMOSENSATION AND DISEASE; OLFACTION PERIPHERY The WUTC Odor Threshold Test: Evaluating Olfactory Ability Using Signal Detection Theory William Tewalt, Irene N Ozbek, McKinney Jessica, Santiago Manuel, Biderman Michael University of Tennessee at Chattanooga Chattanooga, TN, USA #P10 POSTER SESSION I: MULTIMODAL RECEPTION; CHEMOSENSATION AND DISEASE; OLFACTION PERIPHERY Dysautonomia and Chemosensory Dysfunction Noorussabah Shaikh 1 , Alan R. Hirsch 1,2,3,4 1 Smell and Taste Treatment and Research Foundation Chicago, IL, USA, 2 Mercy Hospital and Medical Center/ Department of Medicine Chicago, IL, USA, 3 Rush University Medical Center/ Department of Neurology Chicago, IL, USA, 4 Rush University Medical Center/ Department of Psychiatry Chicago, IL, USA Introduction: Myriad disorders associated with dysautonomias also display chemosensory dysfunction. Given this overlap, assessments of autonomic dysfunction amongst patients of a specialized chemosensory clinic were performed. Methods: 25 consecutive patients at a chemosensory clinic were approached to participate in this IRB approved study. 22 consented. Average age 51 years (range 22 - 69) 8 males and 14 females, with diagnosis of hyposmia/ anosmia (18), dysosmis (3), phantosmia (6), palinosmia (4), hypogeusia/ ageusia (15), dysgeusia (9), phantogeusia (9), burning mouth syndrome (4). All underwent the Quick Smell Identification Test (QSIT), and the Survey of Autonomic Symptoms (SAS) for symptoms and Total Impact Score (TIS) for severity. Results: Our patients demonstrated fewer autonomic symptoms than either those with autonomic disorders or even published controls. There was a significant difference in SAS score in the group as a whole (1.82) compared to published control SAS of ≤3.0 (p= 0.003) and of the group as a whole (4.32) compared to TIS of controls ≤ 7.0 ( p< 0.006). No significance difference between QSIT score and either SAS or TIS was observed (p>0.1). Discussion: This lack of autonomic dysfunction in those chemosensory disorders may reflect a sampling error. Those with autonomic dysfunction may be so burdened by their primary illness they did not seek care for their chemosensory problems, if they even recognized them at all. Alternatively, the SAS and TIS may not be valid in this patient group, while physiologic autonomic testing might demonstrate dysfunction. A larger sample size may have revealed dysautonomia. Conclusion: Lack of autonomic symptoms were seen in those with chemosensory dysfunction. Further investigation of such a connection is warranted. A new odor detection threshold test (WUTC) was developed, using signal detection theory, to address the need for establishing a measure of consistency of subjects’ responses, and the need for introducing different odorants to address different clinical/ research questions. The method of administration used is an improvement over previous methods of testing because the likelihood of desensitization to a single odor over time is minimized. Odorants were chosen on the basis of the possible link of the detection of specific odorants to known disease state. For example, using random presentation, 5 different odors were presented at 9 different levels of concentration twice to a subject with End Stage Renal Disease (ESRD). Blanks were presented 9 times also. Total administration time was 38 minutes. The subject was 100% consistent for isoamyl acetate, 89% percent consistent for P-cresol, and 44% consistent for vanillin and blanks, i.e. the consistency was less than chance suggesting that the subject was guessing. This result is consistent with the prediction that P-cresol may block the detection of vanillin in ESRD patients. Acknowledgements: William H Wheeler Foundation #P12 POSTER SESSION I: MULTIMODAL RECEPTION; CHEMOSENSATION AND DISEASE; OLFACTION PERIPHERY Compensation Gone Awry: Conditions Inducing Regional Oral Sensory Loss May Elevate Obesity Risk Derek J Snyder 1,2 , Linda M Bartoshuk 1,2 1 Center for Smell and Taste, University of Florida Gainesville, FL, USA, 2 Community Dentistry, University of Florida Gainesville, FL, USA Oral afferent nerves innervate portions of the mouth, convey unique arrays of information, and take different paths to the brain. As such, certain health conditions predict specific patterns of regional oral sensory loss: Severe childhood ear infections (otitis media, OM) damage the chorda tympani (CT) and block anterior taste cues, while tonsillectomy damages the glossopharyngeal nerve (IX) and blocks posterior taste/tactile cues. These local effects disinhibit intact oral sensations; for example, CT block elevates IX, trigeminal, and whole-mouth intensity, particularly in supertasters of 6-n-propylthiouracil. Although this compensatory mechanism often mitigates realworld (i.e., whole-mouth) perceptual deficits, our recent data implicate it in a more subtle trend toward long-term obesity risk. In a laboratory study (N = 301), individuals with medical histories indicating either CT damage (i.e., OM) or IX damage (i.e., tonsillectomy) show elevated whole-mouth taste, oral burn and viscosity, and retronasal olfaction (RO). In survey data from a larger sample (N = 6584), such individuals also POSTER PRESENTATIONS Abstracts are printed as submitted by the author(s). 33
Page 1 and 2: AChemS Association for Chemorecepti
Page 4 and 5: Table of Contents 2013 AChemS Meeti
Page 6 and 7: 2013 Annual Meeting Exhibitors EXHI
Page 8 and 9: 2013 Awardees We are pleased to ann
Page 10 and 11: Oral Abstracts #1 GIVAUDAN LECTURE:
Page 12 and 13: #9 INDUSTRY SYMPOSIUM: TASTE AND SM
Page 14 and 15: #17 PLATFORM PRESENTATIONS: OLFACTI
Page 16 and 17: maintenance; demonstrate a contribu
Page 18 and 19: self renew, as well as produce post
Page 20 and 21: #35 SYMPOSIUM: NEW APPROACHES TO PH
Page 22 and 23: auditory cues anticipating the gene
Page 24 and 25: #46 PLATFORM PRESENTATIONS: TASTE P
Page 26 and 27: #51 SYMPOSIUM: EXPERIENCE DRIVEN PL
Page 28 and 29: #57 SYMPOSIUM: THE NEW ‘FACES’
Page 30 and 31: Poster Presentations #P1 POSTER SES
Page 34 and 35: show increased high-fat food avidit
Page 36 and 37: suggest that latency of the N1 OERP
Page 38 and 39: #P23 POSTER SESSION I: MULTIMODAL R
Page 42 and 43: and/or bitter taste are expressed n
Page 46 and 47: the mOR-EG receptor and MUPP1 and i
Page 48 and 49: odor responses. Recently, transient
Page 50 and 51: women; mean age 23.4 years; range 2
Page 52 and 53: #P61 POSTER SESSION II: OLFACTION D
Page 58 and 59: axons into the olfactory bulb where
Page 60 and 61: with the latency of quinine-induced
Page 62 and 63: allows visualization and quantifica
Page 64 and 65: via iontophoretic injection in the
Page 66 and 67: pharmacological inhibition of synap
Page 68 and 69: #P102 POSTER SESSION II: OLFACTION
Page 74 and 75: #P118 POSTER SESSION III: TRIGEMINA
Page 76 and 77: nerve fibers. Nasal SCCs respond to
Page 78 and 79: study was to develop a paradigm for
Page 80 and 81: work was also partly supported by T
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3.3 mm) placed at the olfactory cle
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#P145 POSTER SESSION III: TRIGEMINA
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taste qualities mice can identify i
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These results indicate that IL-1b r
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The purified protein was characteri
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#P167 POSTER SESSION IV: CHEMICAL S
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glutamate and monopotassium glutama
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from postoral sites are integrated
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is predominant in Asians. The G180R
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conserved regions of the AOB. Here
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early postnatal period. This shift
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#P222 POSTER SESSION V: HUMAN TASTE
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ut this was always the first trial.
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The taste test intraclass correlati
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epressive sequence contains binding
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Author Index Abdelhamid, Mostafa -
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Author Index, continued Dillon, T S
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Author Index, continued Karunanayak
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Author Index, continued Müller, Ch
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Author Index, continued Storace, Do
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Visual Program-at-a-Glance Posters
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A NNUAL AChemS Association for Chem
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Abstracts - Association for Chemoreception Sciences

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