From Protein Structure to Function with Bioinformatics.pdf

130 P. Tompa(see Fig. 5.4). Although this correlation has not been statistically tested, in severalcases local irregularity in disorder pattern and local functional region is clearlyestablished. Such a relation has been found in the case of proteinase inhibitor IA 3and p21Cip1 (Vacic et al. 2007), or measles virus nucleoprotein (Bourhis et al.2005), among many other cases (Oldfield et al. 2005b; Uversky et al. 2005; Mohanet al. 2006; Vacic et al. 2007).Fig. 5.4 Prediction of MoRFs in p53. The disorder pattern of p53 was predicted by PONDRVL-XT suggesting the presence of short recognition molecular recognition elements (MoRFs) ofbinding functions. Irregularities (downward spikes) of disorder score match the position of regionsinvolved in Mdm2 binding (a), DNA binding (b) and tetramerization (c) as well as a region withinthe regulatory domain that binds S100B(ββ) dimer (d). The binding partners are shown in blue(Reprinted with permission from Oldfield 2005b. Copyright 2005 American Chemical Society)