Development of hot-melt extrusion as a novel technique for the ...
Development of hot-melt extrusion as a novel technique for the ...
Development of hot-melt extrusion as a novel technique for the ...
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3.2 Powder and ODT characterization .......................................................................493.3 In vivo disintegration time and t<strong>as</strong>te-m<strong>as</strong>king evaluation .....................................573.4 In vitro dissolution ................................................................................................594.0 Conclusions ....................................................................................................................605.0 References……………………………………………………………………….……..60CHAPTER 4: TASTE MASKING OF PARACETAMOL BY HOT MELTEXTRUSION: AN IN VITRO AND IN VIVO EVALUATION1.0 Introduction .......................................................................................................................642.0 Materials and Methods ......................................................................................................652.1 Materials ................................................................................................................652.2 Calculation <strong>of</strong> Hansen solubility parameters .........................................................652.3 Hot-<strong>melt</strong> <strong>extrusion</strong> (HME) process .......................................................................662.4 Thermal analysis ...................................................................................................662.5 X-ray powder diffraction (XRPD) ........................................................................662.6 In vitro drug rele<strong>as</strong>e study .....................................................................................672.7 HPLC analysis .......................................................................................................672.8 In vivo t<strong>as</strong>te m<strong>as</strong>king evaluation ...........................................................................672.9 In vitro t<strong>as</strong>te m<strong>as</strong>king evaluation: Astree e-tongue................................................673.0 Results and discussion .......................................................................................................683.1 Solubility parameters and <strong>extrusion</strong> process .........................................................683.2 Thermal analysis and X– ray solid state characterization studies ........................693.3 In vivo and in vitro t<strong>as</strong>te m<strong>as</strong>king evaluation ........................................................743.4 Dissolution studies ................................................................................................79ix | P a g e