- Page 3 and 4: DECLARATION“I certify that this w
- Page 6 and 7: taste masking effect of the process
- Page 8 and 9: CHAPTER 2: DISSOLUTION ENHANCEMENT
- Page 10 and 11: 3.2 Powder and ODT characterization
- Page 12 and 13: 3.7 In vitro drug release profiles
- Page 15: 3.1 Solubility parameters and extru
- Page 19 and 20: FIGURESFigureN o N oTitle PageCHAPT
- Page 21 and 22: 3.5 Schematic diagram of ODTs hardn
- Page 23 and 24: materials.5.5a Signal comparison be
- Page 25 and 26: 7.4a FTIR spectra of PRP extruded f
- Page 27 and 28: ABBREVIATIONSAbbreviationAPICaStCL,
- Page 29 and 30: PUBLICATIONSOriginal Research Artic
- Page 31 and 32: Melt Extrusion. 39 th Annual meetin
- Page 33 and 34: Maniruzzaman M, Chowdhry BZ, Snowde
- Page 35 and 36: sustained release polymer based pel
- Page 37 and 38: parameters such as screw speed, tem
- Page 39 and 40: (same direction) or counter-rotatin
- Page 41 and 42: 1.5 Formulation research and develo
- Page 43 and 44: However, only a handful of research
- Page 45 and 46: oral and transdermal applications.
- Page 47 and 48: 12. Gryczke A. Melt Extrusion with
- Page 49 and 50: 43. Chokshi RJ, Shah NHS, Sandhu KH
- Page 51 and 52: 70. Klein CE, Chiu Y, Awni W, Zhu T
- Page 53 and 54: spondylitis, tendinitis and headach
- Page 55 and 56: (%, w/w) (%, w/w)INM SOL 20 80INM S
- Page 57 and 58: 2.9 HPLC analysisThe release of INM
- Page 59 and 60: immiscibility of the two components
- Page 61 and 62: Fig. 2.3: Particles size distributi
- Page 63 and 64: Fig. 2.4b: Diffractograms of FMT fo
- Page 65 and 66: Table 2.3: DSC thermal transitions
- Page 67 and 68:
By comparing the Tgs at different l
- Page 69 and 70:
Fig. 2.6a: Drug release profile of
- Page 71 and 72:
4.0 ConclusionsIn the current chapt
- Page 73 and 74:
18. Amidon GL, Lunnernas H, Shah VP
- Page 75 and 76:
interactions facilitate the creatio
- Page 77 and 78:
2.6 Evaluation of tabletsThe prepar
- Page 79 and 80:
dodecahydrate were added into the v
- Page 81 and 82:
Fig. 3.2: X-ray diffraction pattern
- Page 83 and 84:
Table 3.1: Composition of ODT formu
- Page 85 and 86:
disintegrants by absorbing water an
- Page 87 and 88:
grades (3.5-5.5 g water/g polymer)
- Page 89 and 90:
Fig. 3.6: Schematic diagram of fria
- Page 91 and 92:
Table 3.3: Comparison of disintegra
- Page 93 and 94:
IBU has been reported 22% after 2 h
- Page 95 and 96:
18. Verhoeven, T.R.M. De Beer, E. S
- Page 97 and 98:
CHAPTER 4: TASTE MASKING OF PARACET
- Page 99 and 100:
2.3. Hot-melt Extrusion (HME) proce
- Page 101 and 102:
multidimensional statistics on Alph
- Page 103 and 104:
Fig. 4.1a: MTDSC thermograms of pur
- Page 105 and 106:
VA64 showed a baseline shift at 105
- Page 107 and 108:
Fig. 4.2b: Powder XRPD patterns of
- Page 109 and 110:
7 Astree sensors Taste masking effi
- Page 111 and 112:
7 Astree sensorsTaste masking effic
- Page 113 and 114:
exhibited the same trends but slowe
- Page 115 and 116:
13. A. Michalk, V.-R. Kanikanti, H.
- Page 117 and 118:
37. Y. Kong, J.N. Hay, The measurem
- Page 119 and 120:
HME processing conditions, drug/pol
- Page 121 and 122:
otation at 15rpm. The sample was sc
- Page 123 and 124:
2.10 HPLC analysisThe release of CT
- Page 125 and 126:
Fig. 5.1: SEM images (magnification
- Page 127 and 128:
drugs/polymers blends exhibits endo
- Page 129 and 130:
As shown in Fig. 5.3a and b the PM
- Page 131 and 132:
The taste map shows significant dis
- Page 133 and 134:
Fig. 5.5c: Correlation of human sen
- Page 135 and 136:
Fig. 5.6a: Release profiles of CTZ
- Page 137 and 138:
4. Douroumis DD, Gryczke A, Schmink
- Page 139 and 140:
CHAPTER 6: DRUG-POLYMER INTERMOLECU
- Page 141 and 142:
of all PRP and DPD formulations was
- Page 143 and 144:
parameters between each drug and po
- Page 145 and 146:
PRP was determined at 34.74 o C. Ov
- Page 147 and 148:
3.5 Intermolecular interactions of
- Page 149 and 150:
Fig. 6.5a: XPS BE peaks of C 1s PRP
- Page 151 and 152:
For the extruded DPD/L100 samples t
- Page 153 and 154:
N 1s peaks from PRP/L100-55 and DPD
- Page 155 and 156:
Table 6.3: 1 H NMR assignments for
- Page 157 and 158:
Table 6.4: A comparison of T 1 rela
- Page 159 and 160:
18) Forster, A.; Hempenstall, J.; T
- Page 161 and 162:
CHAPTER 7: EVALUATION OF THE INTERR
- Page 163 and 164:
2.3 Flory Huggins (F-H) theory for
- Page 165 and 166:
the bitterness intensity scale from
- Page 167 and 168:
Pythagorean Theorem. In this theory
- Page 169 and 170:
all formulations ranging from 40 -
- Page 171 and 172:
formulations. In addition, the Disc
- Page 173 and 174:
Fig.7.3d. Relationship between resu
- Page 175 and 176:
L100-55-DPD (b) 17.53.6 Fourier Tra
- Page 177 and 178:
Fig 7.5a: XPS surveys of pure PRP,
- Page 179 and 180:
Fig. 7.5d: N 1s BE peaks of DPD and
- Page 181 and 182:
acetaminophen granules: comparison
- Page 183 and 184:
32. Boys SF, Bernardi F. The calcul
- Page 185 and 186:
testosterone and adrenal function.
- Page 187 and 188:
2.7 Tablet preparation and characte
- Page 189 and 190:
Where, W 0 is the initial amount of
- Page 191 and 192:
HCS melting transition and 61.66 o
- Page 193 and 194:
Fig. 8.3: XRD diffractograms of ext
- Page 195 and 196:
Fig. 8.4: HCS release profiles in b
- Page 197 and 198:
Fig. 8.5b: A plot of the HCS releas
- Page 199 and 200:
Eq. (6) is a Korsmeyer-Peppas model
- Page 201 and 202:
5.0 References1. Breitenbach J. Mel
- Page 203 and 204:
CHAPTER 9: CONCLUSIONS AND FUTURE W
- Page 205 and 206:
CHAPTER 10: SUPPLEMENTARY DATA10.1
- Page 207 and 208:
Supp. Fig. 3: C 1s BE peaks for L10
- Page 209 and 210:
445 ms 345 ms 265 ms 185 ms 125
- Page 211 and 212:
8.5 s 5.5 s 2.5 s 1.5 s 500 msS
- Page 213 and 214:
10.2 Supplementary calculationsExam
- Page 215 and 216:
∑ F di = 2352, ∑ F pi = 899100,
- Page 217 and 218:
= N (mw = 418 g/mol)Molecular Weigh
- Page 219:
N = (320000/202= 1584.1584)Molecula