06.12.2012 Views

H e m a t o lo g y E d u c a t io n - European Hematology Association

H e m a t o lo g y E d u c a t io n - European Hematology Association

H e m a t o lo g y E d u c a t io n - European Hematology Association

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Borthakur G, et al. Cause of death in patients with <strong>lo</strong>wer-risk<br />

mye<strong>lo</strong>dysplastic syndrome. Cancer. 2010 May 1;116(9):2174-9.<br />

19. Jadersten M, Montgomery SM, Dybedal I, Porwit-MacDonald<br />

A, Hellstrom-Lindberg E. Long-term outcome of treatment of<br />

anemia in MDS with erythropoietin and G-CSF. B<strong>lo</strong>od. 2005<br />

Aug 1;106(3):803-11.<br />

20. Jadersten M, Malcovati L, Dybedal I, Della Porta MG,<br />

Invernizzi R, Montgomery SM, et al. Erythropoietin and granu<strong>lo</strong>cyte-co<strong>lo</strong>ny<br />

stimulating factor treatment associated with<br />

improved survival in mye<strong>lo</strong>dysplastic syndrome. J Clin Oncol.<br />

2008 Jul 20;26(21):3607-13.<br />

21. List A, Dewald G, Bennett J, Giagounidis A, Raza A, Feldman E,<br />

et al. Lenalidomide in the mye<strong>lo</strong>dysplastic syndrome with chromosome<br />

5q delet<strong>io</strong>n. N Engl J Med. 2006 Oct 5;355(14):1456-65.<br />

22. Tehranchi R, Woll PS, Anderson K, Buza-Vidas N, Mizukami T,<br />

Mead AJ, et al. Persistent malignant stem cells in del(5q)<br />

mye<strong>lo</strong>dysplasia in remiss<strong>io</strong>n. N Engl J Med. Sep 9;363(11):1025-37.<br />

23. Lyons RM, Cosgriff TM, Modi SS, Gersh RH, Hainsworth JD,<br />

Cohn AL, et al. Hemato<strong>lo</strong>gic response to three alternative dosing<br />

schedules of azacitidine in patients with mye<strong>lo</strong>dysplastic<br />

syndromes. J Clin Oncol. 2009 Apr 10;27(11):1850-6.<br />

24. Silverman LR, McKenzie DR, Peterson BL, Holland JF,<br />

Backstrom JT, Beach CL, et al. Further analysis of trials with<br />

azacitidine in patients with mye<strong>lo</strong>dysplastic syndrome: studies<br />

8421, 8921, and 9221 by the Cancer and Leukemia Group<br />

B. J Clin Oncol. 2006 Aug 20;24(24):3895-903.<br />

25. Silverman LR, Demakos EP, Peterson BL, Kornblith AB,<br />

Holland JC, Odchimar-Reissig R, et al. Randomized controlled<br />

trial of azacitidine in patients with the mye<strong>lo</strong>dysplastic syndrome:<br />

a study of the cancer and leukemia group B. J Clin<br />

Oncol. 2002;20(10):2429-40.<br />

26. Issa JP, Garcia-Manero G, Giles FJ, Mannari R, Thomas D,<br />

Faderl S, et al. Phase 1 study of <strong>lo</strong>w-dose pro<strong>lo</strong>nged exposure<br />

schedules of the hypomethylating agent 5-aza-2’-deoxycytidine<br />

(decitabine) in hematopoietic malignancies. B<strong>lo</strong>od. 2004 Mar<br />

1;103(5):1635-40.<br />

27. Kantarjian H, Oki Y, Garcia-Manero G, Huang X, O’Brien S,<br />

Cortes J, et al. Results of a randomized study of 3 schedules of<br />

<strong>lo</strong>w-dose decitabine in higher-risk mye<strong>lo</strong>dysplastic syndrome<br />

and chronic mye<strong>lo</strong>monocytic leukemia. B<strong>lo</strong>od. 2007 Jan<br />

1;109(1):52-7.<br />

28. Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA,<br />

Garcia-Manero G, et al. Multicenter Study of Decitabine<br />

Administered Daily for 5 Days Every 4 Weeks to Adults With<br />

Mye<strong>lo</strong>dysplastic Syndromes: The Alternative Dosing for<br />

Outpatient Treatment (ADOPT) Trial. J Clin Oncol. 2009 Aug<br />

10;27(23):3842-8.<br />

29. WijerMans P, Suciu S, Baila L, Platzbecker U, Giagounidis A,<br />

Selleslag D, et al. Low Dose Decitabine Versus Best<br />

Supportive Care in Elderly Patients with Intermediate or High<br />

Risk MDS Not Eligible for Intensive Chemotherapy: Final<br />

Results of the Randomized Phase III Study (06011) of the<br />

EORTC Leukemia and German MDS Study Groups B<strong>lo</strong>od.<br />

2008;112:226.<br />

30. Neufeld EJ. Oral chelators deferasirox and deferiprone for<br />

transfus<strong>io</strong>nal iron over<strong>lo</strong>ad in thalassemia major: new data,<br />

new quest<strong>io</strong>ns. B<strong>lo</strong>od. 2006 May 1;107(9):3436-41.<br />

31. Greenberg PL, Attar E, Bennett JM, B<strong>lo</strong>omfield CD, De Castro<br />

CM, Deeg HJ, et al. Mye<strong>lo</strong>dysplastic syndromes. J Natl Compr<br />

Canc Netw. 2011 Jan;9(1):30-56.<br />

32. Pullarkat V. Objectives of iron chelat<strong>io</strong>n therapy in mye<strong>lo</strong>dysplastic<br />

syndromes: more than meets the eye? B<strong>lo</strong>od. 2009 Dec<br />

17;114(26):5251-5.<br />

33. Takatoku M, Uchiyama T, Okamoto S, Kanakura Y, Sawada<br />

K, Tomonaga M, et al. Retrospective nat<strong>io</strong>nwide survey of<br />

Japanese patients with transfus<strong>io</strong>n-dependent MDS and aplastic<br />

anemia highlights the negative impact of iron over<strong>lo</strong>ad on<br />

morbidity/mortality. Eur J Haematol. 2007 Jun;78(6):487-94.<br />

34. Rose C, Brechignac S, Vassilief D, Beyne-Rauzy O,<br />

Stamatoullas A, Larbaa D, et al. Positive Impact of Iron<br />

Chelat<strong>io</strong>n Therapy (CT) on Survival in Regularly Transfused<br />

MDS Patients. A Prospective Analysis by the GFM. B<strong>lo</strong>od.<br />

2007;110:249.<br />

35. Leitch HA. Improving clinical outcome in patients with<br />

mye<strong>lo</strong>dysplastic syndrome and iron over<strong>lo</strong>ad using iron chelat<strong>io</strong>n<br />

therapy. Leukemia Research. 2007 Dec;31 Suppl 3:S7-9.<br />

36. Armand P, Kim HT, Cutler CS, Ho VT, Koreth J, Alyea EP, et<br />

al. Prognostic impact of elevated pretransplantat<strong>io</strong>n serum ferritin<br />

in patients undergoing mye<strong>lo</strong>ablative stem cell transplantat<strong>io</strong>n.<br />

B<strong>lo</strong>od. 2007 May 15;109(10):4586-8.<br />

37. Sanz G, Nomdedeu B, Such E, al. e. Independent Impact of<br />

Iron Over<strong>lo</strong>ad and Transfus<strong>io</strong>n Dependency on Survival and<br />

Leukemic Evolut<strong>io</strong>n in Patients with Mye<strong>lo</strong>dysplastic Syndrome.<br />

B<strong>lo</strong>od. 2008;112:640.<br />

London, United Kingdom, June 9-12, 2011<br />

38. Chan L, Gu L, Rauh M, Wells R. Iron Over<strong>lo</strong>ad Accelerates<br />

Deve<strong>lo</strong>pment of Leukaemia: Evidence From a Mouse Model<br />

B<strong>lo</strong>od. 2010:abstract 122.<br />

39. Young NS, Calado RT, Scheinberg P. Current concepts in the<br />

pathophys<strong>io</strong><strong>lo</strong>gy and treatment of aplastic anemia. B<strong>lo</strong>od.<br />

2006 Oct 15;108(8):2509-19.<br />

40. Molldrem JJ, Caples M, Mavroudis D, Plante M, Young NS,<br />

Barrett AJ. Antithymocyte g<strong>lo</strong>bulin for patients with<br />

mye<strong>lo</strong>dysplastic syndrome. British Journal of Haemato<strong>lo</strong>gy.<br />

1997;99(3):699-705.<br />

41. Lim ZY, Killick S, Germing U, Cavenagh J, Culligan D,<br />

Bacigalupo A, et al. Low IPSS score and bone marrow hypocellularity<br />

in MDS patients predict hemato<strong>lo</strong>gical responses to<br />

antithymocyte g<strong>lo</strong>bulin. Leukemia. 2007 Jul;21(7):1436-41.<br />

42. Garg R, Faderl S, Garcia-Manero G, Cortes J, Koller C, Huang<br />

X, et al. Phase II study of rabbit anti-thymocyte g<strong>lo</strong>bulin,<br />

cyc<strong>lo</strong>sporine and granu<strong>lo</strong>cyte co<strong>lo</strong>ny-stimulating factor in<br />

patients with aplastic anemia and mye<strong>lo</strong>dysplastic syndrome.<br />

Leukemia. 2009 Jul;23(7):1297-302.<br />

43. Saunthararajah Y, Nakamura R, Wesley R, Wang QJ, Barrett<br />

AJ. A simple method to predict response to immunosuppressive<br />

therapy in patients with mye<strong>lo</strong>dysplastic syndrome.<br />

B<strong>lo</strong>od. 2003 Oct 15;102(8):3025-7.<br />

44. Zou JX, Rollison DE, Boulware D, Chen DT, S<strong>lo</strong>and EM,<br />

Pfannes LV, et al. Altered naive and memory CD4+ T-cell<br />

homeostasis and immunosenescence characterize younger<br />

patients with mye<strong>lo</strong>dysplastic syndrome. Leukemia. 2009<br />

Jul;23(7):1288-96.<br />

45. S<strong>lo</strong>and EM, Olnes MJ, Shenoy A, Weinstein B, Boss C,<br />

Loeliger K, et al. Alemtuzumab treatment of intermediate-1<br />

mye<strong>lo</strong>dysplasia patients is associated with sustained improvement<br />

in b<strong>lo</strong>od counts and cytogenetic remiss<strong>io</strong>ns. J Clin<br />

Oncol. 2011 Dec 10;28(35):5166-73.<br />

46. Passweg JR, Giagounidis AA, Simcock M, Aul C, Dobbelstein<br />

C, Stadler M, et al. Immunosuppressive therapy for patients<br />

with mye<strong>lo</strong>dysplastic syndrome: a prospective randomized<br />

multicenter phase III trial comparing antithymocyte g<strong>lo</strong>bulin<br />

plus cyc<strong>lo</strong>sporine with best supportive care--SAKK 33/99. J<br />

Clin Oncol. 2011 Jan 20;29(3):303-9.<br />

47. Garcia-Manero G, Couriel D, Tambaro F, Gabrail N, Nadeem<br />

A, Kadia T, et al. A Phase II Randomized Bayesian Study of<br />

Very Low Dose Subcutaneous Decitabine Administered Daily<br />

or Weekly Times Three in Patients with Lower Risk<br />

Mye<strong>lo</strong>dysplastic Syndrome (MDS). B<strong>lo</strong>od. 2009;114 119.<br />

48. Garcia-Manero G, Stoltz ML, Ward MR, Kantarjian H, Sharma<br />

S. A pi<strong>lo</strong>t pharmacokinetic study of oral azacitidine.<br />

Leukemia. 2008 Sep;22(9):1680-4.<br />

49. Garcia-Manero G, Gore S, Skikne B, Cogle C, Ning Y, MacBeth<br />

K, et al. A Phase 1, Open-Label, Dose-Escalat<strong>io</strong>n Study to<br />

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics<br />

of Oral Azacitidine in Patients with Mye<strong>lo</strong>dysplastic<br />

Syndromes (MDS) or Acute Mye<strong>lo</strong>genous Leukemia (AML).<br />

B<strong>lo</strong>od. 2009;114:117.<br />

50. Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, Yang<br />

H, Rosner G, Verstovsek S, et al. Phase 1/2 study of the combinat<strong>io</strong>n<br />

of 5-aza-2’-deoxycytidine with valproic acid in<br />

patients with leukemia. B<strong>lo</strong>od. 2006 Nov 15;108(10):3271-9.<br />

51. Soriano AO, Yang H, Faderl S, Estrov Z, Giles F, Ravandi F, et<br />

al. Safety and clinical activity of the combinat<strong>io</strong>n of 5-azacytidine,<br />

valproic acid, and all-trans retinoic acid in acute mye<strong>lo</strong>id<br />

leukemia and mye<strong>lo</strong>dysplastic syndrome. B<strong>lo</strong>od. 2007 Oct<br />

1;110(7):2302-8.<br />

52. Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X, et al.<br />

DNA methylat<strong>io</strong>n predicts survival and response to therapy in<br />

patients with mye<strong>lo</strong>dysplastic syndromes. J Clin Oncol. 2010<br />

Feb 1;28(4):605-13.<br />

53. Blum W, Garzon R, Klisovic RB, Schwind S, Walker A, Geyer<br />

S, et al. Clinical response and miR-29b predictive significance<br />

in older AML patients treated with a 10-day schedule of<br />

decitabine. Proceedings of the Nat<strong>io</strong>nal Academy of Sciences<br />

of the United States of America. 2010 Apr 20;107(16):7473-8.<br />

54. Yang H, Fang Z, Wei Y, Hu Y, Calin GA, Kantarjian HM, et al.<br />

Levels of miR-29b do not predict for response in patients with<br />

acute mye<strong>lo</strong>genous leukemia treated with the combinat<strong>io</strong>n of<br />

5-azacytidine, valproic acid, and ATRA. American journal of<br />

hemato<strong>lo</strong>gy. 2011 Feb;86(2):237-8.<br />

55. Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H,<br />

Brudno Y, et al. Convers<strong>io</strong>n of 5-methylcytosine to 5-hydroxymethylcytosine<br />

in mammalian DNA by MLL partner TET1.<br />

Science. 2009 May 15;324(5929):930-5.<br />

56. Itzykson R, Kosmider O, Cluzeau T, De Mas V, Dreyfus F,<br />

Quesnel B, et al. Presence of TET2 Mutat<strong>io</strong>n Predicts A Higher<br />

Response Rate to Azacitidine In MDS and AML Post MDS<br />

B<strong>lo</strong>od. 2010 December 4;116 (21):439.<br />

Hemato<strong>lo</strong>gy Educat<strong>io</strong>n: the educat<strong>io</strong>n programme for the annual congress of the <strong>European</strong> Hemato<strong>lo</strong>gy Associat<strong>io</strong>n | 2011; 5(1) | 233 |

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!