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Figure 2. One Year-Overall Survival aftern dUCBT in adults with malignant disorders by status of the disease at transplant. GVHD compared with that of single UCBT but without an increase in non-relapse mortality. Interestingly, in an analysis of 177 patients with acute leukemia, relapse was significantly lower for early stage (CR1-2) patients who received two UCB units, suggesting a greater GVL effect. DFS was 40% and 51% for single and double unit recipients, respectively (p=0.35). 33 The Eurocord group has published results of single and dUCBT for patients with lymphoid malignancies. 34 Relapse incidence was reduced for patients transplanted with a dUCBT compared with those patients transplanted with a single unit. Recently, in a preliminary and unpublished analysis, Eurocord in collaboration with the Acute Leukemia Working party of EBMT have compared the outcomes after dUCBT (n=213) with single UCBT (sUCBT=378) in adult patients with acute myeloid or lymphoblastic leukemia in remission. There were some differences between the two groups: dUCBT recipients were heavier (median weight: 69kg vs. 64 kg, p
16 th Congress of the European Hematology Association Center, published an analysis of 536 patients with malignant disease (AML, n=211; ALL, n=236; CML, n=70 and MDS, n=19) transplanted with a HLA 8/8 allele matched related (MRD, n=204) or an unrelated donor (MUD, n=152), 1 allele mismatched unrelated donors (MMUD, n=52), or double UCB (n=128). 35 All patients received myeloablative conditioning with cyclophosphamide and TBI with fludarabine administered prior to dUCBT, and received GvHD immunosuppression with a calcineurin inhibitor and either methotrexate (MRD, MUD, and MMUD) or mycophenolate mofetil (MRD and dUCBT). While patients’ weight and sex distribution and proportion with standard risk disease were similar, dUCBT patients were younger (median age 25 years, MRD 40 years, MUD 31 years, MMUD 31 years; p1.2x10 5 /kg) (HR 1.51, p=0.04), HLA compatibility (0-1 vs. 2-3) (HR1.5, p=0.05) and a previous autograft (HR1.8, p90%) within 100 days. Early recovery of the circulating neutrophils resulting from the ‘bridge transplant’ of the TPD-MHSC reduced the incidence of serious neutropenia-related infections, also facilitating the use of drugs with myelosuppressive side effects to combat other infections. The observed incidence of GvHD and relapses was low, with overall and disease-free survival curves comparable with those of HLA identical sibling transplants. 17,37,38 Co-transplantation of an UCB unit with haploidentical parenteral multipotent mesenchymal stromal cells McMillan et al. 18 have reported an attempt to speed hematopoietic recovery in a single-institution phase I-II clinical trial in which ex vivo culture-expanded multipotent mesenchymal stromal cells (MSCs) from haploidentical parental donors were infused at the time of UCBT. Fifteen pediatric patients with high-risk acute leukemia were enrolled. Eight patients received MSCs on day 0, with three patients having a second dose | 60 | Hematology Education: the education programme for the annual congress of the European Hematology Association | 2011; 5(1)
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H e m a t o l o g y E d u c a t i o
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Copyright Information ©2011 by Eur
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Editorial Board Education Book Edit
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Acute lymphoblastic leukemia 1-8 Th
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S. Schnell P. Van Vlierberghe A. Fe
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lineage cells, and in differentiati
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FLT3 mutations The FMS-like tyrosin
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44. Bar-Eli M, Ahuja H, Foti A, Cli
Page 18 and 19: J.M. Rowe 1,2 C. Ganzel 1 1 Shaare
Page 20 and 21: treated on the MRC UKALL XII/ECOG29
Page 22 and 23: asparaginase (PEG), where the Esche
Page 24 and 25: or higher. It is, however, importan
Page 26 and 27: 25. Bruggemann M, Schrauder A, Raff
Page 28 and 29: lymphoblastic leukemia: prospective
Page 30 and 31: such as high white blood cell count
Page 32 and 33: doxorubicine, there was a trend tow
Page 34 and 35: of the aging process with respect t
Page 36 and 37: K.L. Rice 1 M. Buzzai 2 J. Altman 1
Page 38 and 39: ing FLT3-ITD, wild-type NPM1, or bo
Page 40 and 41: ciated with gene activation, via th
Page 42 and 43: leukemia with inv(16) and t(8;21):
Page 44 and 45: 99. Parsons DW, Jones S, Zhang X, e
Page 46 and 47: abnormalities, some of which are al
Page 48 and 49: file. 27,31 Thus, the double gene-m
Page 50 and 51: karyotype represents a distinct gen
Page 52 and 53: Table 1. Meta-analysis of 23 random
Page 54 and 55: A recent study by the Center for In
Page 56 and 57: Patients with HLA-matched related o
Page 58 and 59: After allogeneic HSCT, an autologou
Page 60 and 61: A. Bacigalupo Ospedale San Martino,
Page 62 and 63: Table 2. The effect of HLA mismatch
Page 64 and 65: References 1. Petersdorf EW, Malkki
Page 66 and 67: neutrophil and platelet recovery an
Page 70 and 71: infused on day 21. No serious adver
Page 72 and 73: W, et al. Effect of graft source on
Page 74 and 75: TRM was higher for patients who rec
Page 76 and 77: following a myeloablative preparati
Page 78 and 79: effect. Surprisingly, none of the p
Page 80 and 81: nancies. Bone Marrow Transplant. 20
Page 82 and 83: J.G. Gilles Center for Molecular an
Page 84 and 85: 14C12 was humanized by grafting VH
Page 86 and 87: Table 1. VWD Classification. VWD Su
Page 88 and 89: Figure 1. Missense mutations found
Page 90 and 91: associated with an increased bleedi
Page 92 and 93: 49. Brown SA, Eldridge A, Collins P
Page 94 and 95: leed. These issues are especially i
Page 96 and 97: estored function. 43,44 A phase I t
Page 98 and 99: years’ experience of prophylactic
Page 100 and 101: J.A. Burger Department of Leukemia,
Page 102 and 103: chemotaxis, migration across vascul
Page 104 and 105: Regulatory T cells (T reg), identif
Page 106 and 107: 16. Burger JA, Ghia P, Rosenwald A,
Page 108 and 109: TE, Nowakowski GS, et al. CD49d exp
Page 110 and 111: andomized trial demonstrating impro
Page 112 and 113: Conclusions Chemoimmunotherapy has
Page 114 and 115: with multiple comorbidities (≥ 2)
Page 116 and 117: ment was finished in all 100 patien
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Table 2. Treatment recommendation f
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34. Ferrajoli A. The combination of
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to be the source of additional gene
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potential to prevent LSCs from acce
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ABL1 confirms that eradication of d
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65. Fiskus W, Pranpat M, Balasis M,
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alive after 10 years. 11 Hence, CCy
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each arm). A minimal change in myel
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Any discussion about the definition
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H. Kantarjian J. Cortes Leukemia De
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59%; the CCyR rate was 44%. Among p
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ern era of BCR-ABL1 tyrosine kinase
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the hematopoietic system, 10 nor in
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over the period of 6 weeks, demonst
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Data on clonal changes in the blood
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2006 Feb 1;107(3):924-30. 41. Liang
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demonstrated that changes in osteob
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“Mafia” transgenic mice in whic
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68. Coetzee T, Fujita N, Dupree J,
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ization. In WASP deficiency, lympho
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Currently the epistatic relationshi
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R. Küppers Institute of Cell Biolo
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Figure 1. TNFAIP3 mutation in HL ce
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Figure 2. HRS cells and their precu
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Hansmann ML, et al. Detection of cl
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fying patients for whom different a
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prognosis HL, whilst those with res
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12. Noordijk EM, Carde P, Dupouy N,
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A. Sureda Consultant in Haematology
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Figure 1. Long-term outcome of pati
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from a MRD and 18 from MUDs. All pa
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Parker PM, Stein AS, et al. High-do
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R. Stasi Department of Haematology,
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common variants in the regulatory r
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against the TPO receptor (cMpl). 61
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W.B. Mitchell A.A. Miller J.B. Buss
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platelet counts and/or bleeding. Th
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Mpl. Cell. 1994;77(7):1117-24. 6. d
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ity and mortality associated with t
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to azathioprine, and is particularl
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stemming from antibodies against PE
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L. Pasqualucci Institute for Cancer
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cation of molecularly distinct subg
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of cases) 46 and amplifications of
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gene alterations in B cell lymphoma
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W. Wilson National Cancer Institute
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clear distinction among the lymphom
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Treatment strategies in germinal ce
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in ABC DLBCL (Hernandez et al., 201
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DLBCL that mostly occurs in young p
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phoma. J Clin Oncol. 2005;23:5347-5
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Table 1. Diffuse Large B cell Lymph
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sion/relapse are similar to those i
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intensive therapy with curative int
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A. Karsan Genome Sciences Centre an
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Balanced translocations In contrast
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some arm 5q have also been implicat
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(H3K27) methyltransferase, and is a
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38. Starczynowski DT, Morin R, McPh
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G. Garcia-Manero Department of Leuk
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trial evaluating different doses an
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acid. 62 The second was a large mul
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Borthakur G, et al. Cause of death
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P. Krishnamurthy 1 G.J. Mufti 1,2 1
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etween 1995 and 2005. 11 Five hundr
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London, United Kingdom, June 9-12,
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attainment of FDC post DLI. Interes
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myelodysplastic syndromes is associ
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ubiquitous chaperone that promotes
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was thought that they are linked to
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pathologic induction of miR-28 in M
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STATs. Second, levels of HP1 alpha
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72. Irandoust MI, Aarts LH, Roovers
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A.M. Vannucchi Section of Hematolog
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2,559 patients with a diagnosis of
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tant use of aspirin should be caref
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sions at this regard. Based on thes
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in bcr-abl-negative myeloproliferat
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Table 1. Prognostic scoring systems
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Figure 1. Current inhibitors of JAK
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Table 4. A risk-based approach to d
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the flexibility to be adjusted as t
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A. Vacca 1 D. Ribatti 2 1 Departmen
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neovessel building together with MM
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Mevastatin, a specific inhibitor of
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egression of tumor vessels, and app
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diagnosis does not require genetic
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Genetics prognostic tools should be
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sone induction improves outcome of
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Table 1. Conventional chemotherapy
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Novel agents given as consolidation
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dence of peripheral neuropathy, gas
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31. Barlogie B, Tricot G, Anaissie
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Table 1. Major differences between
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first line therapy have shown survi
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transplantation, 7,91 and generally
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methylation characterizes juvenile
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Table 1. Clinical signs of possible
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Table 4. Distribution of CSF involv
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ently results in a less than 5% cum
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90. German-Austrian-Swiss ALL-BFM S
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U. Nowak-Göttl 1 R. Junker 1 A. Kr
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Based on the data obtained from the
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59. Male C, Chait P, Ginsberg JS, e
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Table 1. Characteristic features of
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Table 2. Mutational spectrum of CDA
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megarakaryoblastic leukemia (AMKL)
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R.E. Ware Professor and Vice-Chairm
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protein, cytokines, and soluble adh
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example, improving blood viscosity
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92(9):1266-7. 36. Bensinger TA, Gil
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London, United Kingdom, June 9-12,
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port have also been used. 5 Combina
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Wingard JR, Young J-AH, Boeckh MJ.
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K. Rezvani 1 J. Barrett 2 1 Haemato
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include the childhood infectious il
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Summary Patients undergoing hematop
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Table 1. Key issues. In a retrospec
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invasive method to assess iron over
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stitution but even with optimal sub
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T.M. Hackeng Department of Biochemi
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and inhibits FVIIa, and that the se
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Figure 4. Regulation of coagulation
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T. Baglin Department of Haematology
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Figure 1. Illustration of alternati
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compared with 3.5% in patients with
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49. Hron G, Kollars M, Binder BR, E
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Women receiving vitamin K antagonis
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molecular weight heparin as prophyl
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eral morbidity and mortality. 17-21
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the HOD construct. Furthermore, the
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Goals of future murine studies incl
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F. Noizat-Pirenne C. Tournamille Et
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phenotype. 26 In 2010, we investiga
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ody has been involved in DHTR. 37 T
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antigen. Cases can be encountered d
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S.R. Sloan Harvard Medical School &
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We also analyzed patient databases
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Index of authors Altman J. 27 Bacig
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Cornelissen J. Affiliations to disc
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GlaxoSmithKline (Research Support;
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