06.12.2012 Views

H e m a t o lo g y E d u c a t io n - European Hematology Association

H e m a t o lo g y E d u c a t io n - European Hematology Association

H e m a t o lo g y E d u c a t io n - European Hematology Association

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

transplantat<strong>io</strong>n, 7,91 and generally within the first year.<br />

Early detect<strong>io</strong>n of donor cells by increasing mixed<br />

chimerism may be successfully eradicated by reducing<br />

ongoing immunosuppressive therapy. 94 Donor lymphocyte<br />

infus<strong>io</strong>n (DLI) in JMML relapse is largely unsuccessful.<br />

95 A second or even a third transplantat<strong>io</strong>n gives<br />

a relatively high chance of survival. 8<br />

References<br />

1. Hasle H, Niemeyer CM, Chessells JM, et al. A pediatric<br />

approach to the WHO classificat<strong>io</strong>n of mye<strong>lo</strong>dysplastic and<br />

mye<strong>lo</strong>proliferative diseases. Leukemia. 2003;17:277-282.<br />

2. Baumann I, Niemeyer CM, Bennett JM, Shannon K.<br />

Childhood mye<strong>lo</strong>dysplastic syndrome. In: Swerd<strong>lo</strong>w SH,<br />

Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors.<br />

WHO classificat<strong>io</strong>n of tumours of haematopoietic and lymphoid<br />

tissues. Lyon: IARC; 2008. p. 104-107.<br />

3. Hasle H, Aricò M, Basso G, et al. Mye<strong>lo</strong>dysplastic syndrome,<br />

juvenile mye<strong>lo</strong>monocytic leukemia, and acute mye<strong>lo</strong>id<br />

leukemia associated with complete or partial monosomy 7.<br />

Leukemia. 1999;13:376-385.<br />

4. Kardos G, Baumann I, Passmore SJ, et al. Refractory anemia<br />

in childhood: a retrospective analysis of 67 patients with particular<br />

reference to monosomy 7. B<strong>lo</strong>od. 2003;102:1997-2003.<br />

5. Hasle H, Baumann I, Bergsträsser E, et al. The Internat<strong>io</strong>nal<br />

Prognostic Scoring System (IPSS) for childhood mye<strong>lo</strong>dysplastic<br />

syndrome (MDS) and juvenile mye<strong>lo</strong>monocytic<br />

leukemia (JMML). Leukemia. 2004;18:2008-2014.<br />

6. Kratz CP, Niemeyer CM, Castleberry RP, et al. The mutat<strong>io</strong>nal<br />

spectrum of PTPN11 in juvenile mye<strong>lo</strong>monocytic leukemia<br />

and Noonan Syndrome/mye<strong>lo</strong>proliferative disease. B<strong>lo</strong>od.<br />

2005;106:2183-2185.<br />

7. Locatelli F, Nollke P, Zecca M, et al. Hematopoietic stem cell<br />

transplantat<strong>io</strong>n (HSCT) in children with juvenile<br />

mye<strong>lo</strong>monocytic leukemia (JMML): results of the EWOG-<br />

MDS/EBMT trial. B<strong>lo</strong>od. 2005;105(1):410-419.<br />

8. Yoshimi A, Mohamed M, Bierings M, et al. Second al<strong>lo</strong>geneic<br />

hematopoietic stem cell transplantat<strong>io</strong>n (HSCT) results in<br />

outcome similar to that of first HSCT for patients with juvenile<br />

mye<strong>lo</strong>monocytic leukemia. Leukemia. 2007; 21(3):556-<br />

560.<br />

9. Jaffe ES, Harris NL, Stein H, Vardiman JW. (Eds). World<br />

Health Organizat<strong>io</strong>n classificat<strong>io</strong>n of tumours. Patho<strong>lo</strong>gy and<br />

genetics of tumours of haematopoietic and lymphoid tissues.<br />

Lyon: IARC Press; 2001.<br />

10. Swerd<strong>lo</strong>w SH, Campo E, Harris NL, et al. WHO classificat<strong>io</strong>n<br />

of tumours of haematopoietic and lymphoid tissues. Lyon:<br />

IARC; 2008.<br />

11. Hasle H, Kerndrup G, Jacobsen BB. Childhood mye<strong>lo</strong>dysplastic<br />

syndrome in Denmark: incidence and predisposing condit<strong>io</strong>ns.<br />

Leukemia. 1995;9:1569-1572.<br />

12. Hasle H, Wadsworth LD, Massing BG, McBride M, Schultz<br />

KR. A populat<strong>io</strong>n-based study of childhood mye<strong>lo</strong>dysplastic<br />

syndrome in British Columbia, Canada. Br J Haematol. 1999;<br />

106:1027-1032.<br />

13. Passmore SJ, Chessells JM, Kempski H, Hann IM, Brownbill<br />

PA, Stiller CA. Paediatric MDS and JMML in the UK: a populat<strong>io</strong>n<br />

based study of incidence and survival. Br J Haematol.<br />

2003;121:758-767.<br />

14. Sasaki H, Manabe A, Kojima S, et al. Mye<strong>lo</strong>dysplastic syndrome<br />

in childhood: a retrospective study of 189 patients in<br />

Japan. Leukemia. 2001;15:1713-1720.<br />

15. Niemeyer CM, Aricò M, Basso G, et al. Chronic mye<strong>lo</strong>monocytic<br />

leukemia in childhood: a retrospective analysis of 110<br />

cases. B<strong>lo</strong>od. 1997;89:3534-3543.<br />

16. Stary J, Baumann I, Creutzig U, Harbott J, Micha<strong>lo</strong>va K,<br />

Niemeyer C. Getting the numbers straight in pediatric MDS:<br />

distribut<strong>io</strong>n of subtypes after exclus<strong>io</strong>n of down syndrome.<br />

Pediatr B<strong>lo</strong>od Cancer. 2008; 50(2):435-436.<br />

17. Rosenberg PS, Huang Y, Alter BP. Individualized risks of first<br />

adverse events in patients with Fanconi anemia. B<strong>lo</strong>od. 2004;<br />

104:350-355.<br />

18. Alter BP, Giri N, Savage SA, et al. Malignancies and survival<br />

patterns in the Nat<strong>io</strong>nal Cancer Institute inherited bone marrow<br />

failure syndromes cohort study. Br J Haematol. 2010;150<br />

(2):179-188.<br />

19. Calado RT, Young NS. Te<strong>lo</strong>mere diseases. N Engl J Med.<br />

2009;361(24):2353-2365.<br />

20. Rosenberg PS, Zeidler C, Bolyard AA, et al. Stable <strong>lo</strong>ng-term<br />

London, United Kingdom, June 9-12, 2011<br />

risk of leukaemia in patients with severe congenital neutropenia<br />

maintained on G-CSF therapy. Br J Haematol. 2010;150<br />

(2):196-199.<br />

21. Delhommeau F, Dupont S, Della V, et al. Mutat<strong>io</strong>n in TET2 in<br />

mye<strong>lo</strong>id cancers. N Engl J Med. 2009;360(22):2289-2301.<br />

22. Muramatsu H, Makishima H, Jankowska AM, et al.<br />

Mutat<strong>io</strong>ns of E3 ubiquitin ligase Cbl family members but not<br />

TET2 mutat<strong>io</strong>ns are pathogenic in juvenile mye<strong>lo</strong>monocytic<br />

leukemia. B<strong>lo</strong>od. 2010;115:1069-1975.<br />

23. Maserati E, Minelli A, Pressato B, et al. Shwachman syndrome<br />

as mutator phenotype responsible for mye<strong>lo</strong>id dysplasia/neoplasia<br />

through karyotype instability and chromosomes<br />

7 and 20 anomalies. Genes Chromosomes Cancer.<br />

2006;45(4):375-382.<br />

24. Tamaki H, Ogawa H, Ohyashiki K, et al. The Wilms’ tumor<br />

gene WT1 is a good marker for diagnosis of disease progress<strong>io</strong>n<br />

of mye<strong>lo</strong>dysplastic syndromes. Leukemia. 1999;13(3):<br />

393-399.<br />

25. Cantù-Rajnoldi A, Fenu S, Kerndrup G, van Wering ER,<br />

Niemeyer CM, Baumann I. Evaluat<strong>io</strong>n of dysplastic features<br />

in mye<strong>lo</strong>dysplastic syndromes: experience from the morpho<strong>lo</strong>gy<br />

group of the <strong>European</strong> Working Group of MDS in<br />

Childhood (EWOG-MDS). Ann Hematol. 2005; 84(7):429-<br />

433.<br />

26. Barnard DR, Ka<strong>lo</strong>usek DK, Wiersma SR, et al. Morpho<strong>lo</strong>gic,<br />

immuno<strong>lo</strong>gic, and cytogenetic classificat<strong>io</strong>n of acute mye<strong>lo</strong>id<br />

leukemia and mye<strong>lo</strong>dysplastic syndrome in childhood: a<br />

report from the Childrens Cancer Group. Leukemia. 1996;10:<br />

5-12.<br />

27. Göhring G, Micha<strong>lo</strong>va K, Bever<strong>lo</strong>o HB, et al. Complex karyotype<br />

newly defined: the strongest prognostic factor in<br />

advanced childhood mye<strong>lo</strong>dysplastic syndrome. B<strong>lo</strong>od. 2010;<br />

116(19):3766-3799.<br />

28. Hasle H, Clausen N, Pedersen B, Bendix-Hansen K.<br />

Mye<strong>lo</strong>dysplastic syndrome in a child with constitut<strong>io</strong>nal trisomy<br />

8 mosaicism and normal phenotype. Cancer Genet<br />

Cytogenet. 1995;79:79-81.<br />

29. Woods WG, Neudorf S, Gold S, et al. A comparison of al<strong>lo</strong>geneic<br />

bone marrow transplantat<strong>io</strong>n, auto<strong>lo</strong>gous bone marrow<br />

transplantat<strong>io</strong>n, and aggressive chemotherapy in children<br />

with acute mye<strong>lo</strong>id leukemia in remiss<strong>io</strong>n. B<strong>lo</strong>od.<br />

2001;97(1):56-62.<br />

30. Luna-Fineman S, Shannon KM, Atwater SK, et al. Mye<strong>lo</strong> -<br />

dysplastic and mye<strong>lo</strong>proliferative disorders of childhood: a<br />

study of 167 patients. B<strong>lo</strong>od. 1999;93:459-466.<br />

31. Woods WG, Barnard DR, A<strong>lo</strong>nzo TA, et al. Prospective study<br />

of 90 children requiring treatment for juvenile mye<strong>lo</strong>monocytic<br />

leukemia or mye<strong>lo</strong>dysplastic syndrome: A report from<br />

the Children’s Cancer Group. J Clin Oncol. 2002;20:434-440.<br />

32. Veltroni M, Sainati L, Zecca M, et al. Advanced pediatric<br />

mye<strong>lo</strong>dysplastic syndromes: can immunophenotypic characterizat<strong>io</strong>n<br />

of blast cells be a diagnostic and prognostic tool?<br />

Pediatr B<strong>lo</strong>od Cancer. 2009;52(3):357-363.<br />

33. Al-Rahawan MM, Alter BP, Bryant BJ, Elghetany MT. Bone<br />

marrow cell cycle markers in inherited bone marrow failure<br />

syndromes. Leuk Res. 2008;32:1793-1799.<br />

34. Hasle H, Kerndrup G, Yssing M, et al. Intensive chemotherapy<br />

in childhood mye<strong>lo</strong>dysplastic syndrome. A comparison<br />

with results in acute mye<strong>lo</strong>id leukemia. Leukemia.<br />

1996;10:1269-1273.<br />

35. Albitar M, Manshouri T, Shen Y, et al. Mye<strong>lo</strong>dysplastic syndrome<br />

is not merely “preleukemia”. B<strong>lo</strong>od. 2002;100(3):791-<br />

798.<br />

36. Vardiman JW, Harris NL, Brunning RD. The World Health<br />

Organizat<strong>io</strong>n (WHO) classificat<strong>io</strong>n of the mye<strong>lo</strong>id neoplasms.<br />

B<strong>lo</strong>od. 2002;100(7):2292-2302.<br />

37. Yoshimi A, Baumann I, Fuhrer M, et al. Immunosuppressive<br />

therapy with anti-thymocyte g<strong>lo</strong>bulin and cyc<strong>lo</strong>sporine A in<br />

selected children with hypoplastic refractory cytopenia.<br />

Haemato<strong>lo</strong>gica. 2007;92(3):397-400.<br />

38. Hasegawa D, Manabe A, Yagasaki H, et al. Treatment of children<br />

with refractory anemia: the Japanese Childhood MDS<br />

Study Group trial (MDS99). Pediatr B<strong>lo</strong>od Cancer.<br />

2009;53(6):1011-1015.<br />

39. Webb DKH, Passmore SJ, Hann IM, Harrison G, Wheatley K,<br />

Chessells JM. Results of treatment of children with refractory<br />

anaemia with excess blasts (RAEB) and RAEB in transformat<strong>io</strong>n<br />

(RAEBt) in Great Britain 1990-99. Br J Haematol. 2002;<br />

117:33-39.<br />

40. Creutzig U, Bender-Götze C, Ritter J, et al. The role of intensive<br />

AML-specific therapy in treatment of children with<br />

RAEB and RAEB-T. Leukemia. 1998;12:652-659.<br />

41. Hasle H, A<strong>lo</strong>nzo TA, Auvrignon A, et al. Monosomy 7 and<br />

delet<strong>io</strong>n 7q in children and adolescents with acute mye<strong>lo</strong>id<br />

Hemato<strong>lo</strong>gy Educat<strong>io</strong>n: the educat<strong>io</strong>n programme for the annual congress of the <strong>European</strong> Hemato<strong>lo</strong>gy Associat<strong>io</strong>n | 2011; 5(1) | 299 |

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!