Kompendium 2020 Forschung & Klinik

More documents

Info

TOP-Studien 22 Quantitative Biochemical MRI of Hyaline Cartilage „Our study demonstrated that T2 mapping enables the quantification of patellar cartilage defect progression in untreated defects over time, [indicating its potential as a] predictive marker of patellar cartilage degeneration.“ Sebastian Apprich The department of Orthopedic and Trauma Surgery at the Medical University of Vienna has conducted a successful interdisciplinary collaboration with the onsite High Field MR Centre of Excellence of Prof. Trattnig for years. A major goal is the implementation and improvement of new imaging techniques to explore the natural course of cartilage defects and its potential repair techniques. As a result of this collaboration the article „Potential predictive value of axial T2 mapping at 3 Tesla MRI in patients with untreated patellar cartilage defects over a mean follow-up of four years“ was published in the Journal of Osteoarthritis and Cartilage in <strong>2020</strong>. Magnetic resonance imaging (MRI), with its high spatial resolution and its capability for superior soft tissue contrast, represents the gold standard for diagnosis of incipient osteoarthritis, the follow up of its natural course, and the treatment options. High resolution MRI and newly developed semi-quantitative scoring systems allow for the morphological assessment of the whole joint in patients with Osteoarthritis (OA) (e.g. MOAKS (MRI Osteoarthritis Knee Score) and in patients after surgical cartilage repair (Whole joint MRI assessment of surgical cartilage repair of the knee: cartilage repair osteoarthritis knee score (CROAKS)). Additionally, new imaging techniques (T2/T2* Mapping, dGEMRIC, Sodium Imaging, gagCEST Imaging, …) have evolved over the recent year, which enable a deeper sight into the compositional structure of hyaline cartilage itself. Study: Apprich SR, Schreiner MM, Szomolanyi P, Welsch GH, Koller UK, Weber M, Windhager R, Trattnig S. Potential predictive value of axial T2 mapping at 3 Tesla MRI in patients with untreated patellar cartilage defects over a mean follow-up of four years. Osteoarthritis Cartilage. Osteoarthritis Cartilage. <strong>2020</strong> Feb;28(2):215–222 Advantages of T2 Mapping T2 mapping has proven the capability to gain information about water content and structure of the collagen fiber network of hyaline cartilage by assessment of quantitative T2 relaxation times. For several reasons, T2 mapping provides some major advantages over other techniques. On one hand it is relatively independent from the available field strength of the MRI scanners and can be performed using a 1.5 Tesla scanner and upwards, on the other hand it does not require the administrations of a contrast agent and is feasible within a reasonable scan time. Within the aforementioned publication, we demonstrated the potential of axial T2 mapping for quantification of untreated early-stage patellar cartilage lesions over time and assessed its capability as a potential predictive marker for future progression. Our study cohort consisted of thirty patients (mean age, 36.7 ± 11.1 years; 16 males), with early-stage patellar cartilage
TOP-Studien 23 defects (≤ International cartilage repair Society (ICRS) grade 2) at baseline and no surgical or invasive treatment during the follow up (4.0 ± 1.6 years). To ensure the technical consistency especially of the T2 mapping, hardware, including the MR scanner and the knee coil, as well as the MR sequence protocol, was identical for all subjects at both time points. Following the ICRS grading system, morphological cartilage changes over time were subdivided into a progression group, a non-progression group and regression group. Quantitative analysis of cartilage defects was performed by means of global and zonal T2 mapping (deep and superficial cartilage T2 values) at both time points. Figure 1: A 34-year-old female patient with an ICRS grade 1 cartilage defect of the lateral facet on high-resolution axial PD TSE morphological image at baseline MRI. The corresponding axial T2 map verifies a significant increase in global cartilage T2 values. Furthermore, on the medial apex of the T2 map, a punctual increase of T2 values can be seen at the superficial layer, whereas the morphological image seems to prove that the cartilage is intact (A). At follow up after 3 ½ years (B), the morphological image showed a progression of the cartilage defect, not only for the lateral facet, but also for the medial apex. The corresponding T2 map shows a significant increase.
Page 1 and 2: Kompendium 2020 Forschung & Klinik
Page 3 and 4: Inhalt/Impressum 3 Die Klinik 4 Edi
Page 6 and 7: Zahlen und Fakten 6 Klinische Leist
Page 9 and 10: Zahlen und Fakten 9 Hohe Ambulanzfr
Page 11 and 12: Klinik 11 Neben der Polytrauma-Vers
Page 13 and 14: Die Meniskusversorgung Alle Möglic
Page 15 and 16: Das ÄrztInnenteam 15 Universitäts
Page 17 and 18: Spherox ist das einzig EMA-zugelass
Page 19 and 20: Das ÄrztInnenteam 19 Medizinische
Page 21: Ambulanzen 21 Spezialambulanzen Kli
Page 25 and 26: WE LENGTHEN, TRANSPORT AND GROW BON
Page 27 and 28: TOP-Studien 27 5 5 Patients (-) 10
Page 29 and 30: FRESH AIR FRESH PERSPECTIVE Remove
Page 31 and 32: TOP-Studien 31 Aseptic loosening is
Page 33 and 34: Integriertes Patientenversorgungsko
Page 35 and 36: TOP-Studien 35 Figure 1: Bone miner
Page 37 and 38: TOP-Studien 37 A Prediction Model f
Page 39 and 40: TOP-Studien 39 Figure 2: Graphic vi
Page 41 and 42: TOP-Studien 41 Figure 1: Individual
Page 43 and 44: 3D Biochips for Research on Inflamm
Page 45 and 46: TOP-Studien 45 Chondro-Synovial Cro
Page 47 and 48: TOP-Studien 47 Figure 1. (A) Intrao
Page 49 and 50: TOP-Studien 49 Total Hip Arthroplas
Page 51 and 52: TOP-Studien 51 nerve lesions (1 N.
Page 53 and 54: TOP-Studien 53 1 Volume fill of car
Page 55 and 56: TOP-Studien The Genetic Landscape o
Page 57 and 58: TOP-Studien 57 rare heterozygous lo
Page 59 and 60: TOP-Studien 59 Figure 1: Example of
Page 61 and 62: COPAL ® - ERFOLGREICH GEGEN INFEKT
Page 63 and 64: TOP-Studien 63 Figure 1: Biomechani
Page 65 and 66: TOP-Studien 65 Development of a New
Page 67 and 68: TOP-Studien 67 Table 1: Relative ro
Page 69 and 70: Publikationen 69 Bumberger A, Kolle
Page 71 and 72: Publikationen 71 sou NA, McNally MA
Page 73 and 74:
Publikationen 73 Propensity-Matched
Page 75 and 76:
Publikationen 75 novel hypothetical
Page 77 and 78:
Publikationen 77 ritisches Denken.
Page 79 and 80:
Publikationen 79 Zuteilungsdatum: 2
Page 81 and 82:
Publikationen 81 Payr S: Reviewer J
Page 83 and 84:
Publikationen 83 fracture, Wrist Ar
Page 85 and 86:
Kundenkompetenzzentrum mit Shop & W
Page 87:
·
show all

Kompendium 2020 Forschung & Klinik

Create successful ePaper yourself

Delete template?

Save as template?