Kompendium 2020 Forschung & Klinik

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TOP-Studien 32 Figure 1: Time integrated SDAI was significantly higher in patients with RCL (median; 25th and 75th percentile: 10.8; 8.6 and 15.8) than in controls without RCL (7.0; 2.7 and 15.5) (Figure 1; p=0.043). DMARDs had a protective effect on such risk. This link between inflammation and RCL was further substantiated in the comparison between RA and OA, being particularly evident for TKA. Priv.-Doz. DDr. Christoph Böhler Author: Christoph Böhler is a specialist for Orthopaedics and Traumatology at the Medical University of Vienna. His clinical and scientific focus are on primary and revision arthroplasty. In August 2021 he will start a clinical Adult Reconstruction Fellowship at the University of Toronto, Canada. Local inflammation plays a pivotal role in the pathogenesis of aseptic loosening, by which generation of wear debris between the bearing surfaces leads to activation of macrophages and immune cells, which then release pro-inflammatory cytokines like TNF-alpha and IL-6. These induce osteoclast activation and lead to increased bone resorption, osteolysis and eventually to aseptic loosening. The systemic inflammation of RA may play a role in enhancing the local inflammation underlying the described processes leading to aseptic loosening. The implication of these findings for clinical practice are potentially substantial, at least for individuals with RA and TJA: no patients in remission showed RCL. Analogously to the observation that in sustained remission of RA joint damage does not progress, this makes the case that in the presence of TJA even stricter disease control should be pursued, with clinical remission being the clear treatment target. Biological DMARDs had a protective effect on the risk of RCL. Previously, it has been shown that TNF-inhibitors are able to stop the progression of joint destruction. The majority of the patients in the biological DMARDs group were treated with TNF-inhibitors, potentially also suggesting a role of TNF alpha in the mediation of the inflammatory process leading to aseptic loosening. Conclusion Taken together, inflammation in RA patients, as evidenced by higher levels of disease activity, increases the risk for radiographic loosening after TJA. In OA patients, as a control disease without systemic inflammation, the risk is significantly lower. Biological DMARDs may reduce the risk of RCL, although this would need prospective evaluation. Our data suggest that RA patients with TJA should regularly undergo orthopaedic and radiographic evaluation and, in the context of treating RA to target, might be considered for a more stringent control of disease activity.
Integriertes Patientenversorgungskonzept zur MACT- Gelenksknorpelrekonstruktion Exakte Indikationsstellung Indikations- und Durchführungs empfehlungen der Arbeits gemeinschaft „Geweberegeneration und Gewebe ersatz“ zur Autologen Chondrozyten-Transplanta tion (ACT). Behrens P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier C, Krackhardt T, Löhnert J, Marlovits S, Meenen NM, Mollenhauer J, Nehrer S, Niethard FU, Nöth U, Perka C, Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K (2004). Z Orthop 142: 529-539 Hohe Zelldichte und hohe Zellvitalität des Implantats Effect of cell seeding concentration on the quality of tissue engineered constructs loaded with adult human articular chondrocytes. Concaro S, Nick lasson E, Ellowsson L, Lindahl A, Brittberg M, Gatenholm P (2008). J Tissue Eng Regen Med Flexible Anpassung des Implantats bei der Trans plantation und Wahrung einer homogenen Zellmatrix Stabilization of fibrin-chondrocyte constructs for cartilage reconstruction. Meinhart J, Fussenegger M, Höbling W (1999), Ann Plast Surg 42(6): 673-678 KnorpelbiobsatEntnahme Zellkultur züchten MACTTransplantation Seit 2001 züchtet das Institut für Gewebe- und Organrekonstruk tion, kurz igo®, autologe Zell kul turen für die Knorpel zell rekon struk tion für mehr als 1.500 Patienten erfolgreich an. igo® ist ein privates biopharmazeutisches Unternehmen und Pionier auf dem Gebiet der Zellkulturtechnik und des Tissue Engineerings und aktiv beteiligt an Entwicklung neuer Heilmethoden. Als österreichisches Unternehmen glänzen wir mit der besonderen räumlichen Nähe und dem direkten Kontakt zu unseren Kunden. Informieren Sie sich unter www.igor.at Hohe Compliance des Patienten: Die für die Nachtherapie verwendeten Geräte, CPM Schiene sowie HPM Gerät verfügen über eine ComplianceÜberwachung. Wenn der Patient hier compliant ist, kann man davon ausgehen, dass er auch bei der Physio therapie konsequent mitarbeitet, was für den Erfolg der Therapie wesentlich ist. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002). J Orthop Res, Vol. 20(1): 40-50 Postoperative Therapie Die Kontrollierte Nachtherapie: wird durch das Netz werk von geschulten Physiotherapeuten unterstützt MACTLangzeittherapie Autologous chondrocyte implantation postoperative care and rehabilitation. Hambly K, Bobic V, Wondrasch B, VanAssche D, Marlovits S (2006). Science and Practice. Am J Sports Med 34(6): 1020-1038 A prospective, randomized comparison of traditional and accelerated approaches to postoperative rehabilitation following autologous chondrocyte implantation: 2-year clinical outcomes. Jay R. Ebert, William B. Robertson, David G. Lloyd, M.H. Zheng, David J. Wood, Timothy Ackland (2010). Catilage 1(3)180-187 Wissenschaftliche Publikationen mit igor ChondroSystems Clinical experience with matrix associated autologous chondrocyte transplantation (MACT). Ramadani F, Orthner E, Kitzler B, Wallner B, Burghuber C, Fußenegger M, Meinhart J (2005). Revista de ortopedie si traumatologie 1(6): 106-110 Transplantation of chondrocytes – longtime experiments. Prof. Dr. Lars Peterson (2006) Ergebnis nach ca. 18 Monaten Quelle: <strong>Klinik</strong> Diakonissen Schladming Seit 2006 läuft das Koopera ti onsprojekt Leomed/ Igor der integrierten Patientenver sorgung für Knor pel rekon struktion. Nach Implantation unterstützt Leomed die Patienten bei der Organisation der Nachtherapie. Informieren Sie sich unter www.leomed.at
Page 1 and 2: Kompendium 2020 Forschung & Klinik
Page 3 and 4: Inhalt/Impressum 3 Die Klinik 4 Edi
Page 6 and 7: Zahlen und Fakten 6 Klinische Leist
Page 9 and 10: Zahlen und Fakten 9 Hohe Ambulanzfr
Page 11 and 12: Klinik 11 Neben der Polytrauma-Vers
Page 13 and 14: Die Meniskusversorgung Alle Möglic
Page 15 and 16: Das ÄrztInnenteam 15 Universitäts
Page 17 and 18: Spherox ist das einzig EMA-zugelass
Page 19 and 20: Das ÄrztInnenteam 19 Medizinische
Page 21 and 22: Ambulanzen 21 Spezialambulanzen Kli
Page 23 and 24: TOP-Studien 23 defects (≤ Interna
Page 25 and 26: WE LENGTHEN, TRANSPORT AND GROW BON
Page 27 and 28: TOP-Studien 27 5 5 Patients (-) 10
Page 29 and 30: FRESH AIR FRESH PERSPECTIVE Remove
Page 31: TOP-Studien 31 Aseptic loosening is
Page 35 and 36: TOP-Studien 35 Figure 1: Bone miner
Page 37 and 38: TOP-Studien 37 A Prediction Model f
Page 39 and 40: TOP-Studien 39 Figure 2: Graphic vi
Page 41 and 42: TOP-Studien 41 Figure 1: Individual
Page 43 and 44: 3D Biochips for Research on Inflamm
Page 45 and 46: TOP-Studien 45 Chondro-Synovial Cro
Page 47 and 48: TOP-Studien 47 Figure 1. (A) Intrao
Page 49 and 50: TOP-Studien 49 Total Hip Arthroplas
Page 51 and 52: TOP-Studien 51 nerve lesions (1 N.
Page 53 and 54: TOP-Studien 53 1 Volume fill of car
Page 55 and 56: TOP-Studien The Genetic Landscape o
Page 57 and 58: TOP-Studien 57 rare heterozygous lo
Page 59 and 60: TOP-Studien 59 Figure 1: Example of
Page 61 and 62: COPAL ® - ERFOLGREICH GEGEN INFEKT
Page 63 and 64: TOP-Studien 63 Figure 1: Biomechani
Page 65 and 66: TOP-Studien 65 Development of a New
Page 67 and 68: TOP-Studien 67 Table 1: Relative ro
Page 69 and 70: Publikationen 69 Bumberger A, Kolle
Page 71 and 72: Publikationen 71 sou NA, McNally MA
Page 73 and 74: Publikationen 73 Propensity-Matched
Page 75 and 76: Publikationen 75 novel hypothetical
Page 77 and 78: Publikationen 77 ritisches Denken.
Page 79 and 80: Publikationen 79 Zuteilungsdatum: 2
Page 81 and 82: Publikationen 81 Payr S: Reviewer J
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Publikationen 83 fracture, Wrist Ar
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Kompendium 2020 Forschung & Klinik

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