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74 Mathematics and Economics<br />
Coronavirus – ‘the science of<br />
uncertainty?’<br />
W<br />
hen Canadian physician William<br />
Osler remarked ‘medicine<br />
is a science of uncertainty and<br />
an art of probability’ at the turn of the 20 th<br />
century, it was a sentiment that resonated<br />
strongly. One hundred years on, in the<br />
middle of the coronavirus pandemic, it<br />
certainly feels like we’re facing a ‘science<br />
of uncertainty’, with so many questions<br />
unanswered and our ordinary lives hanging<br />
in the balance.<br />
However,<br />
the uncertainty<br />
we<br />
face now is just<br />
a fraction of<br />
that which humanity<br />
has<br />
dealt with in<br />
the face of pandemics<br />
gone<br />
by and an exploration<br />
of<br />
four of the<br />
world’s deadliest<br />
pandemics shows just how far the<br />
history of thought around disease has<br />
evolved.<br />
“One hundred years<br />
on, in the middle of the<br />
coronavirus pandemic,<br />
it certainly feels like<br />
we’re facing a ‘science<br />
of uncertainty’”<br />
One of the earliest pandemics recorded<br />
was the Plague of Justinian, named after<br />
the Emperor Justinian, I who ruled at the<br />
time, which tore through the Byzantine<br />
Empire and <strong>The</strong> Eastern Mediterranean<br />
in the middle of the sixth century.<br />
Caused by the same disease that caused<br />
the Black Death, the Plague of Justinian<br />
was bubonic, with reports of swellings,<br />
delirium and fever. A contemporary<br />
scholar, Procopius, blamed the disease on<br />
the emperor, ‘declaring Justinian to be either<br />
a devil or that the emperor was being<br />
punished by God for his evil ways’.<br />
Whether or not this personal attack on the<br />
emperor was a widespread theory, the<br />
idea of plague being a punishment from<br />
God certainly was and one of the main<br />
home remedies was prayer, along with<br />
powders that had been ‘blessed’ by saints,<br />
magic charms and amulets, all of which<br />
were designed to appease supernatural<br />
forces. Other home remedies included<br />
cold-water baths and drug taking, none of<br />
which were noted to be particularly effec-<br />
<strong>The</strong> Black Death killed up<br />
tive, of which the same can be<br />
to 60% of all Europeans at<br />
said for professional treatment<br />
the time<br />
by a physician, which was<br />
based on Galen’s ideas of balancing the<br />
body’s humours.<br />
By the end of the pandemic, an estimated<br />
25 million people had died – a staggering