In Pursuit of the Gene

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PANGENES © 85 other in hybrids. Mendel had coined the terms dominating for those traits that were passed on to the hybrid unchanged, and recessive for those that receded or completely disappeared, while De Vries had called them active and latent. What was perhaps most striking of all, and must have given De Vries many sleepless nights, was that Mendel had demonstrated the 3-to-1 ratio of dominants to recessives among the progeny of hybrids exactly as De Vries had predicted in his 1:2:1 law of pangenes.
[To view this image, refer to the print version of this title.] ¬The “handsome” portrait of Mendel. From Gregor Johann Mendel: Leben, werk und wirkung (Berlin: Julius Springer, 1924), after p. 7, Tagfel 7. With kind permission of Springer Science and Business Media.
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IN PURSUIT OF THE GENE
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To my wife, Ann Hochschild, whose u
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ILLUSTRATIONS Charles Darwin and Fr
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PREFACE ¨ SCIENCE IS FUNDAMENTALLY
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PREFACE © xi diana University, and
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PREFACE © xiii each of the more co
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CHAPTER 1 Viva Pangenesis ¨ IN THE
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VIVA PANGENESIS © 3 ber of small d
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VIVA PANGENESIS © 5 sumption that
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VIVA PANGENESIS © 7 university car
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VIVA PANGENESIS © 9 banish obsessi
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VIVA PANGENESIS © 11 Military Coll
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VIVA PANGENESIS © 13 tions of pang
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VIVA PANGENESIS © 15 Still playing
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VIVA PANGENESIS © 17 Although Galt
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VIVA PANGENESIS © 19 and Louisa tr
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VIVA PANGENESIS © 21 tion]. What l
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CHAPTER 2 Reversion to the Mean ¨
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REVERSION TO THE MEAN © 25 a price
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REVERSION TO THE MEAN © 27 the pop
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REVERSION TO THE MEAN © 29 In fact
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REVERSION TO THE MEAN © 31 jects h
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[To view this image, refer to the p
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Page 52 and 53: REVERSION TO THE MEAN © 37 regular
Page 56 and 57: REVERSION TO THE MEAN © 41 self ha
Page 58 and 59: REVERSION TO THE MEAN © 43 cape re
Page 60 and 61: CHAPTER 3 Galton’s Disciples ¨ I
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Page 64 and 65: GALTON’S DISCIPLES © 49 fection
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Page 70 and 71: GALTON’S DISCIPLES © 55 species
Page 72 and 73: GALTON’S DISCIPLES © 57 see the
Page 74 and 75: GALTON’S DISCIPLES © 59 ety meet
Page 76 and 77: GALTON’S DISCIPLES © 61 that no
Page 78 and 79: GALTON’S DISCIPLES © 63 lished r
Page 80 and 81: GALTON’S DISCIPLES © 65 lights m
Page 85 and 86: 70 ¨ PANGENES he took a position a
Page 87 and 88: 72 ¨ PANGENES In the following yea
Page 89 and 90: 74 ¨ PANGENES his own. In the plac
Page 91 and 92: 76 ¨ PANGENES transported from the
Page 93 and 94: 78 ¨ PANGENES sized: The first he
Page 95 and 96: 80 ¨ PANGENES tical study of the l
Page 97 and 98: 82 ¨ PANGENES ber,” which posite
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Page 103 and 104: 88 ¨ MENDEL younger Mendel having
Page 105 and 106: 90 ¨ MENDEL lower grades. The phys
Page 107 and 108: 92 ¨ MENDEL brids, following the i
Page 109 and 110: 94 ¨ MENDEL invisible, and the sam
Page 111 and 112: 96 ¨ MENDEL A less sinister interp
Page 113 and 114: 98 ¨ MENDEL way had their position
Page 115 and 116: 100 ¨ MENDEL In the same paper, Me
Page 117 and 118: 102 ¨ MENDEL sequestration if Mend
Page 121 and 122: 106 ¨ REDISCOVERY planning to publ
Page 123 and 124: 108 ¨ REDISCOVERY which each pange
Page 125 and 126: 110 ¨ REDISCOVERY installment of h
Page 127 and 128: 112 ¨ REDISCOVERY one closely rese
Page 129 and 130: 114 ¨ REDISCOVERY That winter, in
Page 131 and 132: 116 ¨ REDISCOVERY only had Weldon
Page 135 and 136: 120 ¨ MENDEL WARS Conference on Hy
Page 137 and 138: 122 ¨ MENDEL WARS patches of color
Page 139 and 140: 124 ¨ MENDEL WARS The final exchan
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Page 143 and 144: 128 ¨ MENDEL WARS ing, and that wa
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136 ¨ MENDEL WARS mous studbook, w
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138 ¨ MENDEL WARS soon as he had f
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140 ¨ MENDEL WARS his research, Hu
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142 ¨ MENDEL WARS In February, Wel
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146 ¨ CELL BIOLOGY and Schleiden h
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148 ¨ CELL BIOLOGY [To view this i
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150 ¨ CELL BIOLOGY first noticed b
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152 ¨ CELL BIOLOGY generation. Thi
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154 ¨ CELL BIOLOGY tween nuclear d
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156 ¨ CELL BIOLOGY been working fo
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158 ¨ CELL BIOLOGY Although he mad
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160 ¨ CELL BIOLOGY [To view this i
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162 ¨ CELL BIOLOGY The clear depic
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166 ¨ SEX CHROMOSOMES were two kin
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168 ¨ SEX CHROMOSOMES dicated that
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170 ¨ SEX CHROMOSOMES to all previ
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172 ¨ SEX CHROMOSOMES and set them
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174 ¨ SEX CHROMOSOMES bryology had
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176 ¨ SEX CHROMOSOMES loid set of
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178 ¨ SEX CHROMOSOMES next summer
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180 ¨ SEX CHROMOSOMES first explai
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182 ¨ SEX CHROMOSOMES somes, givin
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186 ¨ THE FLY ROOM sity worked tog
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188 ¨ THE FLY ROOM world-renowned
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190 ¨ THE FLY ROOM ress in the Stu
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192 ¨ THE FLY ROOM near one anothe
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194 ¨ THE FLY ROOM would often lea
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196 ¨ THE FLY ROOM when he took Mo
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198 ¨ THE FLY ROOM more convenient
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200 ¨ THE FLY ROOM most extreme ca
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202 ¨ THE FLY ROOM to the extent t
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204 ¨ THE FLY ROOM responsible for
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206 ¨ THE FLY ROOM but theoretical
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CHAPTER 11 Oenothera Reconsidered
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OENOTHERA RECONSIDERED © 211 winge
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OENOTHERA RECONSIDERED © 213 succe
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OENOTHERA RECONSIDERED © 215 tatio
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OENOTHERA RECONSIDERED © 217 compl
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OENOTHERA RECONSIDERED © 219 outcr
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CHAPTER 12 X-Rays ¨ WITH THE RESOL
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X-RAYS © 223 through, due to the i
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X-RAYS © 225 Suddenly Muller jumpe
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X-RAYS © 227 C � B experiments a
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X-RAYS © 229 Bateson’s plenary a
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X-RAYS © 231 Bateson’s famous fo
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X-RAYS © 233 Cramped, noisy, overh
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X-RAYS © 235 ing. “It was funny
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X-RAYS © 237 birth of the baby, wh
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X-RAYS © 239 spontaneous lethals (
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X-RAYS © 241 the Fifth Internation
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CHAPTER 13 Triumph of the Modern Ge
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TRIUMPH OF THE MODERN GENE © 245 D
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TRIUMPH OF THE MODERN GENE © 247 l
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TRIUMPH OF THE MODERN GENE © 249 w
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TRIUMPH OF THE MODERN GENE © 251 t
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+ + B f B f + B B fu + B B + f + TR
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TRIUMPH OF THE MODERN GENE © 255 f
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TRIUMPH OF THE MODERN GENE © 259 F
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TRIUMPH OF THE MODERN GENE © 263 O
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TRIUMPH OF THE MODERN GENE © 265 m
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TRIUMPH OF THE MODERN GENE © 269 p
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TRIUMPH OF THE MODERN GENE © 271 p
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TRIUMPH OF THE MODERN GENE © 273 s
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EPILOGUE ¨ IN FEBRUARY 1944, Oswal
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locks were laid down that accounted
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EPILOGUE © 281 In November 1951, W
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EPILOGUE © 283 The discovery in 19
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EPILOGUE © 285 characterization of
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EPILOGUE © 287 master gene on chro
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EPILOGUE © 289 the genome could be
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NOTES ACKNOWLEDGMENTS INDEX
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294 ¨ NOTES TO PAGES 4-8 help in p
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296 ¨ NOTES TO PAGES 19-28 58. Let
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298 ¨ NOTES TO PAGES 36-42 35. Let
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300 ¨ NOTES TO PAGES 50-58 F.R.S.
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302 ¨ NOTES TO PAGES 70-81 2. Ibid
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304 ¨ NOTES TO PAGES 84-89 27. Ibi
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306 ¨ NOTES TO PAGES 93-95 29. The
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308 ¨ NOTES TO PAGES 106-111 (1900
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310 ¨ NOTES TO PAGES 114-120 24. I
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312 ¨ NOTES TO PAGES 125-132 15. A
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314 ¨ NOTES TO PAGES 137-146 55. W
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316 ¨ NOTES TO PAGES 150-153 15. E
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318 ¨ NOTES TO PAGES 157-160 38. M
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320 ¨ NOTES TO PAGES 167-171 6. Ib
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322 ¨ NOTES TO PAGES 173-176 33. A
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324 ¨ NOTES TO PAGES 182-186 of Tw
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326 ¨ NOTES TO PAGES 190-192 multi
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328 ¨ NOTES TO PAGES 195-200 31. M
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330 ¨ NOTES TO PAGES 202-210 Franc
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332 ¨ NOTES TO PAGES 213-215 13. I
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334 ¨ NOTES TO PAGES 218-222 28. B
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336 ¨ NOTES TO PAGES 225-228 14. T
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338 ¨ NOTES TO PAGES 235-239 “Ob
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340 ¨ NOTES TO PAGES 245-254 9. H.
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342 ¨ NOTES TO PAGES 258-262 51. J
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344 ¨ NOTES TO PAGES 266-272 84. S
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346 ¨ NOTES TO PAGES 276-283 123.
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348 ¨ NOTES TO PAGES 288-289 Becau
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350 ¨ ACKNOWLEDGMENTS also deeply
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“Accessory Chromosome, The: Sex D
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ell curve. See normal distribution
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34, 50, 60-61; and study of plant m
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“fly room.” See Columbia Univer
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ics; evolution; gemmules; genes; hy
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y, 306n37; early life of, 87-88; fu
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222-223; Russian geneticists and, 2
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studies of, 79-85; Wichura and, 100
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Stalin, Joseph, 258, 262, 267, 269,
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In Pursuit of the Gene

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