222–223; Russian geneticists and, 232, 235–236, 247–248, 254–270, 272, 274, 275; stability <strong>of</strong> genes and, 200, 202–204, 206, 273; structural <strong>the</strong>ory <strong>of</strong> genes and, 278–279, 280, 281, 282; and suicide attempt, 248–249, 251, 272; University <strong>of</strong> Texas and, 226–227, 262, 272; Wilson and, 185, 189–190, 196, 226, 336n18. See also Muller, Jessie Jacobs; Muller, Thea Kantorowicz Muller, Jessie Jacobs: fragile relationship with H. J. Muller, 233, 234– 235, 247, 257, 270; as math instructor, 234, 236; Muller’s letters from Europe to, 256, 259, 269, 270; Muller’s suicide attempt and, 248, 249; Offermann and, 248, 257; as wife and mo<strong>the</strong>r, 256, 259, 269, 270 Muller, Mimi Held, 273–274 Muller, Thea Kantorowicz, 270, 271– 272, 273 Mullis, Kary, 285 mutations: as De Vries’s term for discontinuous variations, 110, 113, 130; dominant, 84–85, 93–94, 197, 198, 311n11; evolution and, 206; measuring frequency <strong>of</strong>, 221–227, 334n3; Morgan’s work on, 177–183, 191–192, 197, 199–200, 210; Muller’s <strong>the</strong>ory <strong>of</strong>, 221–228, 273, 279; nomenclature for, 197–198; radiationinduced, 180, 199, 236–241, 243– 244; randomness <strong>of</strong>, 265–266; recessive, 84–85, 93–94, 197, 198, 216, 328n40; reverse, 228, 252, 259–260; INDEX © 365 temperature and, 238, 273; visible, 239–240. See also balanced lethal factors; C �B chromosome; dominance; genes; lethal mutations; recessiveness; “sports”; names <strong>of</strong> species Mutations<strong>the</strong>orie, Die (De Vries), 77, 110 Naegeli, Karl von, 96–99, 100 Napp, Cyril Franz, 89, 90 Natural <strong>In</strong>heritance (Galton), 43, 45, 46, 51, 80, 116–117 natural selection: Darwin’s <strong>the</strong>ory <strong>of</strong>, 1, 2–3, 43, 45, 46, 50, 54, 130, 165, 176, 190; Morgan’s conversion to, 276; mutations and, 213, 216; small variations and, 53–54, 57, 63, 189. See also evolution; variation nature. See heredity “nature and nurture,” origin <strong>of</strong> phrase, 30 Nobel Prize, 188, 276 Nordenskioeld, Erik, 315n5 normal distribution: biometry and, 45– 46, 47, 51, 79–80, 81; human stature and, 10, 37, 45; inheritance <strong>the</strong>ory and, 10, 11–12, 31–33, 78; sex determination and, 222. See also probability; statistics nurture, scientific disposition and, 27– 28, 29, 31 Oeno<strong>the</strong>ra: as apparent exception to Mendel’s law, 111–113, 213; brevistylis variety <strong>of</strong>, 302n16; De Vries’s work on, 76–77, 78, 80, 111–112, 113, 119, 176, 177, 179; explanation for
366 ¨ INDEX Oeno<strong>the</strong>ra (continued) atypical behavior <strong>of</strong>, 213–217, 273; mutation <strong>the</strong>ory and, 227, 273, 333n24; nonequivalence <strong>of</strong> sexes in crosses <strong>of</strong>, 309n15, 332n21; origin <strong>of</strong>, 217–219 Offermann, Carlos, 247–248, 249, 256– 257, 259 O’Grady, Marcella, 155 “On a <strong>Gene</strong>ralized Theory <strong>of</strong> Alternative <strong>In</strong>heritance” (Pearson), 131 “On Blood-relationship” (Galton), 20, 23 “On Heredity” (Weismann), 73–74, 150–151 On <strong>the</strong> Formation <strong>of</strong> Vegetable Mould through <strong>the</strong> Actions <strong>of</strong> Worms (Darwin), 72 “On <strong>the</strong> <strong>Gene</strong>ration <strong>of</strong> Animals” (Aristotle), 3 “On <strong>the</strong> Law <strong>of</strong> Ancestral Heredity” (Pearson), 63, 65 On <strong>the</strong> Movements and Habits <strong>of</strong> Climbing Plants (Darwin), 70 On <strong>the</strong> Origin <strong>of</strong> Species (Darwin), 1, 3, 4, 69, 130 “On Twin Hybrids” (De Vries), 214 oöcytes, 169 Osborne, Henry Fairfield, 232 Out <strong>of</strong> <strong>the</strong> Night (Muller), 249, 267, 272 Painter, Theophilus Shickel, 226, 244, 245, 249, 264, 283, 342n54 pangenes: De Vries and, 73, 74–75, 78– 79, 81, 82–84, 113, 213–214; Mendelism and, 108, 113. See also anlag; gemmules; germ-plasm; idioplasm pangenesis: Darwin’s <strong>the</strong>ory <strong>of</strong>, 1–4, 11, 69, 72–74, 110; De Vries’s revised <strong>the</strong>ory <strong>of</strong>, 72–85, 110; Galton- Darwin experiment on, 12–21 parasyn<strong>the</strong>sis, 318n48 particulate <strong>the</strong>ory <strong>of</strong> inheritance. See gemmules; pangenes Pascal’s triangle, 302–303n19, 303n21 Patterson, John Thompson, 226 Pauling, Linus, 279, 280, 281 Pauling, Peter, 281 PCR (polymerase chain reaction), 285 Pearson, Karl: horse coat color problem and, 132–133, 134–135, 136, 138, 141; on mouse hybridization experiment, 312n16; as publisher <strong>of</strong> Biometrika journal, 114, 115, 116; and revision <strong>of</strong> Galton’s ancestral law, 63, 65, 115, 117; and use <strong>of</strong> biometrics in evolution study, 46–47, 58, 60, 117, 127, 131–132; as Weldon’s close friend, 46, 116, 140, 142 peas, Mendel’s study <strong>of</strong> inheritance in, 33–34, 92–97, 98, 99, 106, 107, 108, 112, 311n13 Perkins, William, 315n12 Phylloxera, 171–172, 174, 175, 176 Physical Basis <strong>of</strong> <strong>In</strong>heritance, The (Morgan), 186–187 pink (Drosophila mutation), 202, 203, 330n51 plants: De Vries’s mutant hybrids <strong>of</strong>, 74–76, 78–79, 83–84; Gaertner’s book on, 90–91; Galton’s studies <strong>of</strong> inheritance in, 33–37, 41; regenerative capabilities <strong>of</strong>, 74; statistical
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To my wife, Ann Hochschild, whose u
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ILLUSTRATIONS Charles Darwin and Fr
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PREFACE ¨ SCIENCE IS FUNDAMENTALLY
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PREFACE © xi diana University, and
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CHAPTER 1 Viva Pangenesis ¨ IN THE
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