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liiiMIIIfl~UDliiiMIII~U - Biblioteca de la Universidad Complutense ...

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2.2. MECANISMO DE REGULACIÓN A CORTO PLAZO (INDEPENDIENTE DE<br />

MALONIL-CoA) DE LA CPT-I<br />

Introducción<br />

2.2.1 Are cytoskeletal components involved in the control ofhepatic carnitine<br />

palmitoyltransferase<br />

(Biochem. Biophys. Res. Cominun. 224, 754-759<br />

2.2.2 Involvement ofCa<br />

t/calmodulin-<strong>de</strong>pen<strong>de</strong>ntprotein kinase JI in the<br />

activation ofcarnitine palmytoiltransferase 1 by okadaic acid in rat<br />

hepacytes.<br />

(Biocliem. J. 321, 211-216)<br />

2.2.3 Malonyi-CoA-in<strong>de</strong>pen<strong>de</strong>nt acute control ofhepatic carnitine<br />

palmitoyltransferase 1 activity. Role ofCa2*/Calmodulin <strong>de</strong>pen<strong>de</strong>n 1<br />

protein kinase II and cytoskeIeton components<br />

(J. Biol. Chem., en revisión)<br />

Discusión<br />

2.3. POSIBLE PAPEL FISIOLÓGICO DE LA REGULACIÓN A CORTO PLAZO<br />

(INDEPENDIENTE DE MALONIL-CoA) DE LA CPT-I<br />

Introducción<br />

2.3.1 Loss ofresponse ofcarnitine paImitoyltransferase. 1 lo okadaic acid in<br />

transformedhepatic celis.<br />

(Biochem. Pliarmacol., en revisión)<br />

2.3.2 Control ofhepaticfatty acid oxidation by 5>-AMP-activatedprotein<br />

kinase involves a malonyl-CoA-<strong>de</strong>pen<strong>de</strong>nt and a malonyl-CoA<br />

in<strong>de</strong>pen<strong>de</strong>nt mechanism.<br />

(Arcli. Biochem. Biophys. 337, 169-175)<br />

2.3.3 Studies on Ihe intracellu<strong>la</strong>r localization ofacetyl-CoA carboxi<strong>la</strong>se<br />

(Biochem. Biophys. Res. Commun. 233, 253-257)<br />

Discusión<br />

3. DISCUSIÓN GENERAL Y CONCLUSIONES<br />

Regu<strong>la</strong>ción a corto p<strong>la</strong>zo <strong>de</strong> <strong>la</strong> CPT-I<br />

Principales proteína quinasas implicadas en el control a corto p<strong>la</strong>zo <strong>de</strong> <strong>la</strong> CPT-I<br />

z) Ct/CMPKIJ<br />

u) AMPK<br />

Efectos <strong>de</strong> otros mediadores

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