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HYPERTONIA ÉS NEPHROLOGIA - eLitMed.hu

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2002; 6 (S3): 39–46. NeoRecormon ® Quality of Life 2001 43<br />

ÖSSZEFOGLALÁS, AZ EDDIGI VIZSGÁLATOK TA-<br />

NULSÁGAI<br />

Az eddigi vizsgálatok alapján megállapíthatjuk, hogy az<br />

anaemia jelentõs rizikótényezõként szerepel az idült veseelégtelenségben<br />

jelentkezõ progresszív szívizom-hypertrophiában,<br />

valamint a dializáltak cardiovascularis halálozásában. A<br />

cardiovascularis károsodás a veseelégtelenségben korán kezdõdik.<br />

Az anaemia részleges korrekciója javítja a dializáltak<br />

túlélését, de nem normalizálja a szívelváltozásokat. A vérszegénység<br />

teljes korrekciója a szívizom kitágulását megakadályozza,<br />

de a már kialakult dilatatio, szívelégtelenség tünetei<br />

mellett további cardiovascularis elõnye jelenleg nem bizonyított.<br />

Ezek alapján az eddigi rh-EPO-kezelés stratégiájának<br />

módosítása, az anaemia korai, predialízis stádiumban történõ<br />

kezelése, megelõzése javasolt.<br />

IRODALOM<br />

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Patient mortality and survival. Am J Kidney Dis 1998;<br />

32(S1):69-80.<br />

2. Charra B, Calemard E, Ruffet M, et al. Survival as an index of<br />

adequacy in dialysis. Kidney Int 1992; 41:1286-1291.<br />

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1998; 32(S3):112-119.<br />

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Causes of death. Am J Kidney Dis 1998; 32(S1):81-88.<br />

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disease. Am J Cardiol 1989; 64:222-224.<br />

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cardiomyopathy, morbidity, and mortality in end-stage renal<br />

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11. Pascual J, Teruel J.L, Moya J.L, et al. Regression of left<br />

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mortality and morbidity–The experience of the Lombardy<br />

Dialysis Registry. Nephrol Dial Transplant 1998; 13: 1642–<br />

1644.<br />

13. Besarab A, Bolton WK, Browne JK, et al. The effects of normál<br />

as compared with low hematocrit values in patients with cardiac<br />

disease who are receiving hemodialysis and epoetin. N Engl J<br />

Med 1998; 339: 584-590.<br />

14. Macdougall IC, Ritz E. The normal haematocrit trial in dialysis<br />

patients with cardiac disease: are we any the less confused abaut<br />

target haemoglobin? Nephrol Dial Transplant 1998; 13:3030-<br />

3033.<br />

15. Foley RN, Parfrey PS, Morgan J, et al. Effect of hemoglobin<br />

levels in hemodialysis patients with asymptomatic cardiomyopathy.<br />

Kidney Int 2000; 58:1325-1335.<br />

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performance and associated electrolyte changes after haemoglobin<br />

normalization: a comparative study in haemodialysis<br />

patients. Nephrol Dial Transplant 2000; 15:1425.<br />

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the hematocrit has a beneficial effect on quality of life and is safe<br />

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Dial Transplant 2001; 16(S2):16-18.<br />

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