Aprile Vol.2 N° 1 - 2006 - Salute per tutti

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A cknowledgments This project was supported by a grant of Laboratories Vichy Italy. Special thanks to all the dermatologists who joined the project, they are all cited in the web: www.isplad.org. Authors declare no conflict of interest. R eferences “Healthy Skin 2005”: results of an Italian study on healthy population with particular regard to the aging phenomenon 1. Sparavigna A, Di Pietro A, Setaro M. Healthy skin: significance and results of an Italian study on healthy population with particular regard to sensitive skin International Journal of Cosmetic Science 2005; 27:327-331 2. Sparavigna A, Di Pietro A, Setaro M. Sensitive skin: correlation with skin surface and microrelief appearance. Skin Research and Technology 2006; 12:7-10 3. Lévêque J.L. Quantitative Assessment of Skin Aging. Clinics in Geriatric Medicine 2001; 17:673-689 4. Corcuff P., de Rigal J., Makki S, et al. Skin Relief and Aging. J Soc Cosmet Chem 1983; 34:177- 182 5. Setaro M., Abella M.L., Sparavigna A., Lévêque J.L. Ptosis of submental skin: objective measurements and effect of age. Skin Research and Technology 2004; 10:251-256 6. Setaro M, Sparavigna A. Irregularity skin index (ISI): a tool to evaluate skin surface texture. Skin Research and Technology 2001; 7:159-163 7. Issachar N, Gall Y, Borell MT, Poelman, MC. pH measurements during lactic acid stinging test in normal and sensitive skin. Contact Dermat 1997; 36:152-155 8. Draelos ZD “Sensitive skin: perceptions, evaluation and treatment.” Am. J. Contact Dermat. 1997; 8:67-78 9. Muizzuddin N, Marenus KD, Maes DH. Factors defining sensitive skin and its treatment Am. J. Contact Dermat. 1998; 9:170-175 10. Placzek M, Kerkmann U, Bell S, Koepke P, Przybilla B. Tobacco smoke is phototoxic. British Journal of Dermatology 2004; 150:991-3 11. Raitio A, Kontinen J, Rasi M, Bloigu R, Oikarinen A. Comparison of clinical and computerized image analyses in the assessment of skin ageing in smokers and non-smokers. Acta Dermato-Venereologica 2004; 84:422-427 12. Choi EH, et al. The skin barrier state of aged hairless mice in a dry environment. British Journal of Dermatology 2002; 147:244-9 Journal of Plastic Dermatology 2006; 2, 1 29
Adele Sparavigna 1 Michele Setaro 1 Margherita Genet 2 Linda Frisenda 2 1 DermIng, Clinical Research and Bioengineering Institute, Monza, Milan, Italy 2 Polichem SA, Lugano Pazzallo, Switzerland Equisetum arvense in a new transungual technology improves nail structure and appearance SUMMARY I ntroduction Changes in nail consistency may be due to impairment of one or more factors involved in healthy nail appearance and include variation in water content or in keratin constituent (1). Equisetum arvense in a new transungual technology improves nail structure and appearance Two clinical trials were carried out with a new formulation based on Equisetum arvense (a plant extract rich in organic silica) and a sulfur donor in a hydro-alcoholic solution, with the aim to evaluate the efficacy and preventive activity of this new formulation on nail alterations. In both studies, visual assessment of nail plate and optical profilometry of nail replicas were performed comparing treated and contralateral untreated nails of each subject. For the first study, 36 women with nail plate alterations applied the test product every night on the nails of one hand, randomly assigned, for 28 days. Results demonstrated a significant reduction in longitudinal grooves as well as an 85% reduction in patients reporting lamellar splitting of treated nails, while no significant change was observed in untreated controls. In the second study, 22 women with nail plate alterations applied the test product randomly on the nails of one hand only, on alternating days, preferably in the evening, for 14 days. After drying, a common nail polish was applied on the fingernails of both hands and removed by an organic solvent every other day, before next product application. Results from this study showed a significant decrease (P< .001) of lamellar splitting compared to baseline with the test product (82% of cases). Nail fragility of treated nails decreased significantly (P < .001) compared to baseline. The product showed 90% of cases with 1 grade improvement and only 10% did not change. Control nails showed 5% with 1 grade improvement, 5% worsened and 90% did not change. Longitudinal grooves were significantly reduced by 28% after 14 days of treatment, despite the harmful effects of organic solvents. The results confirmed the efficacy and preventive activity of the test product in the improvement of nail plate alterations (splitting, fragility and longitudinal grooves). KEY WORDS: Equisetum arvense, Transungual technology, Nail Normal nails contain approximately 15% of water, this percentage increases after prolonged immersion in water and the nail becomes soft. A low lipid content may decrease the nail’s ability to retain water, consequently, if water con- Journal of Plastic Dermatology 2006; 2, 1 31
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