Aline Alves da Silva

xABSTRACTTheory of DoctorateProgram of Masters degree in Veterinary MedicineFederal University of Santa Maria, RS, BrazilCLINICAL EVALUATION OF Rattus norvegicus AFTER ANTI-INFLAMMATORY THERAPY WITH SELECTIVE INHIBITOR OR NOT FORCOX-2 FOR ALLOMETRIC SCALINGAUTHOR: ALINE ALVES DA SILVAADVISER: JOÃO EDUARDO WALLAU SCHOSSLERDates and place of the defense: Santa Maria, August of 2004.The anti-inflammatories no esteroidais (AINEs) they are the drugs of larger prescriptionall over the world, for humans and for animals. They combat the inflammation, the pain,the temperature increase, could also inhibit the aggregation plaques. They act inhibitingthe production of the acid araquidônico and ciclooxigenases (COXs) decreasing likethis, the prostaglandins production. They become separated in inhibitors no selective forCOX-1 and 2, being those the most traditional; and in selective inhibitors for COX-2,considered more modern drugs. AINEs no selective they reduce the production of all ofPGs, constituent or not. Already the selective ones just inhibit harmful PGs, thatyou/they act in the inflammatory reaction, preserving PGs that maintains, for instance,the protection to the stomach and the renal perfusão. In that study the hepatic functionof Rattus norvegicus was evaluated after the use of AINE no selective, cetoprofeno andof selective AINE, valdecoxib. The doses administered to the animals were calculatedaccording to the scaling allometric. The allometric is a method that allows to extrapolate