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Interior 2_2005.qxd - Oftalmologia.ro

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OFTALMOLOGIA 2 - 2005<br />

ADMINISTRAREA<br />

INTRAVITREANA DE<br />

MEDICAMENTE<br />

B. C^RSTOCEA, LAURA MACOVEI<br />

REZUMAT<br />

Administrarea intravitrean` direct` reprezint` calea cea mai simpl` ]i mai rapid`<br />

de a ob\ine concentra\ii eficace de substan\` la locul leziunii ]i este rezervat` patologiei<br />

rezistente la tratamentele pe cale obi]nuit`.<br />

CUVINTE CHEIE:<br />

• injectare intravitrean`,<br />

• implante intravitreene.<br />

ABSTRACT<br />

The direct intravitreal administration represents the easiest and quickest method<br />

for obtaining efficient substance concentrations closer to the lesions and is reserved to the<br />

pathology which is resistant to the common treatments.<br />

KEY WORDS:<br />

• intravitreal injections,<br />

• intravitreal implants.<br />

INJECTAREA INTRAVITREAN| DE MEDICAMENTE<br />

Injectarea intravitrean` de medicamente prezint` o serie de avantaje ce o impun ca o<br />

op\iune de abordat [n managementul patologiei vitreo-retiniene: vit<strong>ro</strong>sul ca mediu de<br />

injectare este u]or accesibil, avascular ]i [n contact direct cu polul posterior, substan\a se<br />

poate delivra rapid, difuzeaz` rapid ]i se ob\in concentra\ii [n vit<strong>ro</strong>s mai mari fa\` de<br />

administrarea local` sau sistemic`, absen\a reac\iilor adverse sistemice [n cazul unor<br />

medicamente bine tolerate de ochi.<br />

Dezavantajele inject`rii intravitreene sunt: toxicitate pe structurile oculare (retin`,<br />

cristalin), administrare frecvent` ]i pe o perioad` lung` de timp necesar` [n bolile c<strong>ro</strong>nice,<br />

reparti\ie neomogen` ]i pu\in predictibil` a substan\ei dac` structura vit<strong>ro</strong>sului sau<br />

barierele hemato-oculare sunt alterate, nu poate trata leziunile sistemice din bolile infec-<br />

\ioase sau inflamatorii asociate afec\iunii oculare.<br />

5

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